regulated – Page 31 – Communicable Diseases Research

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Research Article

Published on 2011-10-202022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

Research Article

Published on 2011-08-172022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS,

[키워드] 95% CI 95% confidence interval adjusted odds ratio affected After age and sex AHSG Analysis AOR association Beijing Cohort cohort study Concentration CYP4F3 cytochrome P450 demonstrated family found Gene Genotype genotype data genotyped Guangzhou HCW healthy control Human human neutrophil inflammation-associated gene Inflammatory investigated leukotriene Linkage disequilibrium liver LTB4 Macrophage nucleocapsid protein polymorphism promoter Protein regulated Regulation required SARS Coronavirus SARS virus SARS-CoV SARS-CoV infection selected serum Serum level significantly SNP statistical analysis supported susceptibility the patient transcriptional activity variant
[DOI] 10.1371/journal.pone.0023730 PMC 바로가기 [Article Type] Research Article

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

Research Article

Published on 2011-05-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses
[DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article

Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques

Research Article

Published on 2011-04-202022-10-28
Journal: PLoS ONE [Category] Coronavirus, Fulltext, 조류인플루엔자,

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

Research Article

Published on 2010-04-082022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype
[DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Research Article

Published on 2007-08-102022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication
[DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article

Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer

염증 및 암에 대한 지표로서의 인간 키티나제 및 키티나제 유사 단백질

Review

Published on 2007-05-032022-08-07
Journal: Biomarker Insights [Category] Biochemistry,

[키워드] a major Activation AMCase Arthritis Asthma atherosclerotic atherosclerotic plaques Biomarker C-terminal chitin-binding domain Cancer cells cell proliferation chitin chitinase chitinase-like protein chitinase-like proteins chitinases Chitotriosidase chondrocyte chondrocytes circulation cirrhosis contribute cytokine detected diagnostic diagnostic and prognostic marker enzymatic activity enzyme epithelial cells examination family fibrosis found Gaucher Disease glucocorticoid Glucocorticoid treatment Glucocorticoids Glyco_18 Domain Glyco_18 domain-containing protein hepatic fibrosis Human human diseases Human Glyco_18 domain-containing proteins hydrolyse hydrolytic activity IL-4 Indicator Inflammatory bowel disease inherited lysosomal storage involved lipid-laden macrophage lipid-laden macrophages Macrophage macrophage activation macrophages marker mechanism mediators Migration murine murine lectin neutrophil Neutrophils Non-invasive Osteoarthritis overproduced Pathogenesis Patient Prognostic marker progression Protein Proteins regulated rheumatoid arthritis sensitivity Serum level SI-CLP Side effect Side effects solid tumors synovial cells Th2 cytokine Th2 cytokine IL-4 Th2-environment the cell therapy tissue tissues Tumor tumors unique upregulated YKL protein YKL proteins YKL-39 YKL-40 YM1
PMC 바로가기 [Article Type] Review

Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)

Research Article

Published on 2005-09-212022-10-28
Journal: BMC Genomics [Category] Coronavirus,