Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 VariantsResearch Article Published on 2021-10-122022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] ACE2 receptor binding adenoviral vector alleviate Cell COVID-19 effective expression full-length S glycosylation help immunization insect cells mice mRNA nanoparticle Neutralizing antibody response pandemic platform produced Protein protein-based vaccine response robust S1 domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants secreted spike subunit the SARS-CoV-2 Vaccine Vaccines variants VLP Wuhan [DOI] 10.1128/mBio.01813-21 PMC 바로가기 [Article Type] Research Article
Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodiesSARS-COV-2 스파이크 순환 돌연변이에 대한 분자 근거 Bamlanivimab 및 Etesevimab monoclonal 항체를 피할 수 있습니다.Article Published on 2021-10-122022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] Antibody neutralization bamlanivimab circulating Computational biology and bioinformatics Effect elicited etesevimab immune immune surveillance in silico information L452R Lilly LY-CoV555 molecular molecular dynamics monoclonal antibodies monoclonal antibody Mutation neutralization predicted Receptor binding domain reported S-RBD SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant Spike protein Surveillance the SARS-CoV-2 Vaccine Viral viral evolution Viral protein wild-type SARS-CoV-2 [DOI] 10.1038/s41598-021-99827-3 PMC 바로가기 [Article Type] Article
Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 20212020년 7월-2021년 5월 헌혈을 기반으로 한 미국 감염 및 백신 유도 SARS-CoV-2 혈청 유병률 추정Article Published on 2021-10-122022-09-11 Journal: JAMA [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI adjust age antibodies black Blood blood collection blood donation Blood donations blood donor Blood donors Combined conducted COVID-19 case cross-sectional cross-sectional study cumulative defined detectable donor sample estimate Estimated Ethnicity Final General population Hispanic incidence rates Infection median National nucleocapsid occurred Older organization organized outcome Prevalence proportion reduced risk regions repeated reported representing SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence SARS-CoV-2 spike selected Seroprevalence specimen subsequent tested vaccination Vaccine Washington Weighting women [DOI] 10.1001/jama.2021.15161 PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677HQ677H 보유 관련 SARS-CoV-2 변종 중화Observation Published on 2021-10-052022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] (United Kingdom Alpha Alpha) B.1.1.7 B.1.351 B.1.525 Beta Beta) Bluebird Brazil concern E484K Effect epistatic interaction epistatic interactions Gamma highlight increase MONITOR Mutation mutations N501Y neutralization Neutralizing antibodies neutralizing antibody Q677H RBD RBD mutations Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike mutations SARS-CoV-2 variant SARS-CoV-2 variants sensitivity South Africa spike spike mutations syncytium formation the RBD United Kingdom variant variant of concern variants Viral viral infectivity VOCs was determined [DOI] 10.1128/mBio.02510-21 PMC 바로가기 [Article Type] Observation
Longitudinal Humoral Responses after COVID-19 Vaccination in Peritoneal and Hemodialysis Patients over Twelve WeeksArticle Published on 2021-10-042022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age anti-S1 IgG antibody Anti-spike antibody binding BNT162b2 booster booster vaccination caused COVID-19 COVID-19 vaccination demonstrated dialysis Follow-up healthy control healthy controls Hemodialysis homologous Humoral response individual IQR longitudinal median mounted multicenter neutralization neutralizing antibody Patient patients Peritoneal dialysis reduced required response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike second vaccination Seroconversion significantly susceptible vaccination Vaccination strategies Vaccination strategy vaccine-induced antibody variants of concern Week [DOI] 10.3390/vaccines9101130 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study자가면역 염증성 류마티스 질환 성인 환자 및 일반 인구에서 BNT162b2 mRNA COVID-19 백신의 면역원성과 안전성: 다기관 연구Observational Study Published on 2021-10-012022-09-12 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 임상, 진단, [키워드] adverse event Autoimmune binding antibody unit biological therapy BNT162b2 mRNA BNT162b2 mRNA vaccine Control control group COVID-19 COVID-19 pandemic COVID-19 vaccine death defined Disease activity Efficacy evaluated Factor General population Glucocorticoids herpes zoster IgG IgG antibody IgG level immunogenic immunogenicity Inflammatory Major majority Messenger RNA methotrexate Mild MMF mRNA multicentre Older age Patient patients postvaccination Protein reduced remained rheumatic disease rituximab S1/S2 safety profile SARS-CoV-2 spike seronegative Seropositivity significantly significantly lower symptomatic case Treatment two-dose regimen vaccination Vaccine vaccine dose were assessed were measured [DOI] 10.1136/annrheumdis-2021-220647 PMC 바로가기 [Article Type] Observational Study
Proteases and variants: context matters for SARS-CoV-2 entry assays프로테아제 및 변이체: SARS-CoV-2 진입 분석에 대한 컨텍스트 문제Review Published on 2021-10-012022-09-11 Journal: Current opinion in virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 arising cell line complexity coronavirus 2 dependent on driven by entry mechanisms flexible Humoral immunity implication in vivo other coronaviruses pathogenicity pathway priming protease Proteases Protein proteolytic proteolytic activation receptor respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic efficacy tissue Transmission variant virus entry [DOI] 10.1016/j.coviro.2021.07.004 PMC 바로가기 [Article Type] Review
The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression이식 인구에서 SARS-CoV-2 반응성 세포 및 체액 면역의 크기와 기능은 면역 억제에도 불구하고 일반 인구와 유사합니다Article Published on 2021-10-012022-09-11 Journal: Transplantation [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute phase adaptive immune system Analysis analyzed anti-SARS-CoV-2 Antibody titer Antiviral antiviral response CD4+ CD4+ T cell CD8+ T cell CD8+ T cells cellular Cohort COVID-19 COVID-19 infection COVID-19 patients Cytokines effective feature flow cytometry frequencies Frequency generate groups handling humoral Immunity Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression implication lung median time membrane memory T cells Neutralizing antibodies neutralizing antibody neutralizing antibody titers no difference no differences not differ Patient patient cohorts patients Population presenting produced proinflammatory cytokines Protective raise recruited renal SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike specific neutralizing antibodies spike- spike-protein statistical significance T cell T cells Transplant Txs vaccination [DOI] 10.1097/TP.0000000000003755 PMC 바로가기 [Article Type] Article
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responsesSARS-COV-2 특이 적 T 세포 반응을 결정하기위한 진단 도구로서 플루오 스팟 분석의 평가Research Article Published on 2021-09-302022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] addition Affect aligning Amino acid appear assays blood sample Blood samples calculated cellular Cellular immune response cellular immune responses cellular response Chain Reaction Cohort COVID-19 patients cross-reactive determine diagnostic diagnostic value dual endemic HCoVs evaluated HCoVs HCW healthcare worker Healthcare workers hospitalized COVID-19 patient house human coronavirus human coronaviruses IFN-γ IgG immune response immune responses individuals less nucleocapsid Numerous peptide peptide pool peptide pools polymerase chain polymerase chain reaction post infection reference standard Release repeated Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sensitivity Seroconversion serological serological assays serology seronegative Specificities specificity T cell T cell response [DOI] 10.1371/journal.pone.0258041 PMC 바로가기 [Article Type] Research Article
Fast SARS-CoV-2 Variant Detection Using Snapback Primer High-Resolution MeltingArticle Published on 2021-09-282022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] costly COVID testing COVID-19 detection feasibility help High-resolution high-resolution melting infecting less Lineage melting methodology mutations neutralization over PCR responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant snapback primer Spread suggested the disease vaccine-induced antibodies variant variants virus whole-genome sequencing [DOI] 10.3390/diagnostics11101788 PMC 바로가기 [Article Type] Article