severe cases – Page 31 – Communicable Diseases Research

Comparison of patients hospitalized with COVID-19, H7N9 and H1N1

Research Article

Published on 2020-12-022022-10-29
Journal: Infectious Diseases of Poverty [Category] COVID-19, MERS, SARS, 신종인플루엔자,

Continuous tracking of COVID-19 patients’ immune status

COVID-19 환자의 면역 상태를 지속적으로 추적

Article

Published on 2020-12-012022-09-11
Journal: International immunopharmacology [Category] SARS, 치료기술,

[키워드] Admission AUC basophils Blood blood cell CD3 CD4 CD8 Cell change clinical evolution Continuous contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokine storms Cytokines Depletion diagnostic Efficacy enrolled eosinophil eosinophils flow cytometer HCs Health healthy control help hospital IFN-γ IL-10 IL-2 IL-6 Immune monitoring Immune status increase in Infection Laboratory leucocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild mild case Monocytes neutrophil Neutrophils predict Secondary infection severe cases severe group significantly sustained T cells the disease
[DOI] 10.1016/j.intimp.2020.107034 PMC 바로가기 [Article Type] Article

A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments against COVID-19

코로나19에 대한 렘데시비르, 하이드록시클로로퀸, 로피나비르-리토나비르 치료의 전임상 및 임상 효능 검토

Review

Published on 2020-12-012022-09-11
Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 비임상, 신약개발, 임상, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age animal model Anosmia approved Atypical Atypical pneumonia beta-coronavirus breath candidate capital city cardiovascular disease characterized China clinical Clinical studies clinical study clinically combinations Compound coronavirus Coronavirus 2019 cough COVID-19 COVID-19 patient diabetes Diabetes Mellitus disease drug Efficacy Emergency use Epidemiological investigation Epidemiological investigations Fever gastrointestinal symptoms health emergency Health Organization Hydroxychloroquine in vitro include Infectious virus Lopinavir Lopinavir-ritonavir malaise novel Novel coronavirus outbreak outcome pandemic pathogen Pneumonia Preclinical protocol Remdesivir respiratory review Ritonavir RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases Shortness of breath Spread suggested Symptom these compounds treat treatment for COVID-19 Typical typical symptoms virus WHO World Health Organization Wuhan
[DOI] 10.1177/2472555220958385 PMC 바로가기 [Article Type] Review

Syncytia formation by SARS-CoV-2-infected cells

SARS-CoV-2에 감염된 세포에 의한 융합체 형성

Article

Published on 2020-12-012022-09-11
Journal: The EMBO Journal [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

The differences of clinical characteristics and outcomes between imported and local patients of COVID-19 in Hunan: a two-center retrospective study

Research

Published on 2020-11-262022-10-28
Journal: Respiratory Research [Category] COVID-19,

Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China

Research

Published on 2020-11-262022-10-28
Journal: Respiratory Research [Category] COVID-19,

[키워드] 2019 coronavirus disease age alanine aminotransferase analyzed Characteristics Chest CT children China clinical Clinical characteristics Clinical features Cohort Comorbidities convalescent patient Convalescent patients Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patients develop diabetes discharged discharged patient disease disease severity elevated evaluate fibrosis Follow-up ground-glass opacity had more hospitalized patient hypertension IgG IgM antibody IQR laboratory data Limited Liver injury lymphocytopenia lymphopenia median men non-severe cases non-severe patients Older patchy Patient patients physician Pneumonia positive rate previous study radiological features rehabilitation Result Retrospective study severe cases severe COVID-19 patients Severe patient severe patients significant difference staff Thyroid Treatment with COVID-19 women
[DOI] 10.1186/s12931-020-01580-0 PMC 바로가기 [Article Type] Research

Treatment of COVID‐19 patients with the anti‐CD6 antibody itolizumab

Original Article

Published on 2020-11-252022-10-31
Journal: Clinical & Translational Immunology [Category] COVID-19,

[키워드] administration adverse event age antibody Autoimmune disease Biomarker cascade CD6 Clinical data Combination Comorbidities Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Cytokine release syndrome death Deterioration discharged events expressed FiO2 glycoprotein hospitals Hyperinflammatory hyperinflammatory state ICU IL‐6 individual itolizumab lethality rate Lower Lung function moderate monoclonal antibody morbidity and mortality Mortality Most patient multiple cytokine National neurological manifestation NLR objective pathway Patient patients Prevent prevented proportion protocol reduce reduced Result SARS‐CoV‐2 SARS‐COV2 Secondary objective severe cases Severe patient severe patients significantly subject T lymphocyte T‐cell activation Th1/Th17 therapy time treated Treatment Ventilation
[DOI] 10.1002/cti2.1218 PMC 바로가기 [Article Type] Original Article

Factors associated with acute cardiac injury and their effects on mortality in patients with COVID-19

급성 심장 손상과 관련된 요인 및 COVID-19 환자의 사망률에 미치는 영향

Article

Published on 2020-11-242022-09-10
Journal: Scientific Reports [Category] SARS, 바이오마커,

[키워드] ACI Acute cardiac injury Analysis Biomarkers Brain brain natriuretic peptide C-reactive protein Cardiology Clinical characteristics collected Combination COVID-19 cumulative determine develop disease severity Effect elevated Elevation Factor Gender hs-CRP identify IL-6 in-hospital mortality in-patient incidence independent risk factor independent risk factors interleukin interleukin-6 Kaplan–Meier method Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase Logistic regression male Mortality N-terminal NT-proBNP oxygen oxygen saturation Patient patients with COVID-19 peptide proportion radiological Risk factors sensitivity severe cases severe group Severe patient severe patients severity significantly higher significantly increased the disease Tongji Hospital Treatment was used were used Wuhan
[DOI] 10.1038/s41598-020-77172-1 PMC 바로가기 [Article Type] Article

Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

림프구감소증은 COVID-19 환자의 질병 중증도 및 회복을 예측했습니다: 단일 센터, 후향적 연구

Research Article

Published on 2020-11-182022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2

Research Article

Published on 2020-11-182022-10-28
Journal: PLoS ONE [Category] COVID-19, SARS,