signaling pathway – Page 31 – Communicable Diseases Research

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

Research Article

Published on 2014-05-222022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus

Research

Published on 2014-05-062022-10-28
Journal: Virology Journal
[Category] Coronavirus,

[키워드] activated acute respiratory syndrome ADE Analysis Anti-viral antibodies antibody Antibody-dependent enhancement binding Cell cells chimeric competent consequence coronavirus cytoplasmic dependent on downstream elicited ENhance evaluate Fcγ receptor FcγR Fluorescence full-length Health heat-inactivated human coronavirus human macrophage human macrophages human monocyte-derived macrophage IgGs immune Immune cell immune complex Infection Infection route information Lentiviral particle Macrophage Microscopy molecular mechanism naïve observation Occurrence Pathogens performed polymerase chain Pseudotypes Public Quantitative receptor receptors Replication reported response Result risk RT-PCR SARS-CoV SARS-CoV vaccine serum shown Signaling signaling domain signaling pathway spike Support susceptibility transcriptase Trimers vaccination virus
[DOI] 10.1186/1743-422X-11-82 PMC 바로가기 [Article Type] Research

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

Research Article

Published on 2014-03-142022-10-29
Journal: Protein & Cell
[Category] Coronavirus,

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease

게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다

Research Article

Published on 2012-11-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed
[DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

Tetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다

Research Article

Published on 2012-09-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light
[DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article

The Regulatory Network of Natural Competence and Transformation of Vibrio cholerae

Vibrio cholerae의 자연적 능력 및 변형의 규제 네트워크

Research Article

Published on 2012-06-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Analysis aquatic bacterium aquatic environment assays Author autoinducers Bacteria Bacterial bacterium CAMP carbon Carbon catabolite repression catabolite repression Cell chitin chitinous chitinous exoskeleton colonization Combination competence condition conditions consequence contribute Degradation degradation products dependent on determine developmental different DNA ecological environmental niche environmental reservoirs Evidence Evolution Express expression pattern Extracellular Factor found Gene Gene Expression gene transfer Genes Genetic genetic transformation genomes growth heterogeneity heterogeneous homogeneous horizontal gene Horizontal gene transfer human pathogen immunological detection initiate intracellular signaling investigated involved lead maintenance majority metabolism mode natural Natural competence natural transformation network organism pathogenic phenotype protein level protein levels quantitative RT–PCR quorum-sensing pathways regions regulated regulatory circuit released reporter fusions required signaling cascade signaling pathway single cell level tested TfoX the cells transcriptional transfer transformation V. cholerae Vibrio cholerae western blot Western blot analysis zooplankton
[DOI] 10.1371/journal.pgen.1002778 PMC 바로가기 [Article Type] Research Article

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Research Article

Published on 2011-10-202022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced
[DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article

Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma

Review

Published on 2011-10-142023-06-09
Journal: World journal of gastroenterology
[Category] B형 간염,

[키워드] cytokine Genotype Hepatitis B virus Hepatocellular carcinoma immune cells Mutation Prognosis signaling pathway Viral load.
[DOI] 10.3748/wjg.v17.i38.4258 PMC 바로가기 [Article Type] Review

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

Caenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn
[DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article