Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 단일 센터에서 입원한 어린이의 Mycoplasma pneumoniae 및 Chlamydia pneumoniae 감염에 대한 역학 연구Article Published on 2022-03-212022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory tract infection age Atypical can not center Characteristics children Children's Hospital China Chlamydia Chlamydia pneumoniae COVID-19 COVID-19 pandemic detection rate epidemiological Epidemiological study epidemiological study. Hospitalized IgM antibody IMPROVE Infection measure Mycoplasma Mycoplasma pneumoniae number of children Older outbreak Pathogens pneumoniae positive positive rate positive rates reached reduction in respiratory respiratory tract respiratory tract infection SARS-CoV-2 significantly lower Spread spread of COVID-19 These data university Zhejiang [DOI] 10.3389/fcimb.2022.843463 PMC 바로가기 [Article Type] Article
Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 InfectionBNT162b2 mRNA 백신 접종 또는 SARS-CoV-2 감염 후 HIV-1 감염 대상에서 혈청 및 점막 SARS-CoV-2-항체의 특성화Article Published on 2022-03-212022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] all subject all subjects analysed Anti-spike anti-Spike IgG antibody Antiretroviral therapy BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine characterization convalescent detectable dose ELISA Frequency HIV-1 humoral humoral immune response IgA IgA antibodies IgA antibody IgG immune Immunity immunogenicity indicate induce investigated mRNA vaccination mRNA vaccine mucosal mucosal immunity neutralization activity Neutralization assay Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity no significant difference of BNT162b2 Patient patients Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serum serum levels significantly higher significantly lower specific antibodies spike IgA spike-specific antibody response subject subjects uninfected vaccination Vaccine vaccine response vaccinee vaccinees while [DOI] 10.3390/v14030651 PMC 바로가기 [Article Type] Article
A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold clusterResearch article Published on 2022-03-212022-10-05 Journal: Nano Today [Category] 신약개발, [키워드] approved arthritis treatment bind cells Cluster COVID-19 crystal Cys145 decrease down-regulate expression Gold cluster hamster hamsters in vivo Inflammatory Inflammatory cytokine inhibiting Injury intrinsic intrinsically lung mice NFκB outcome pathway patients reduce released reveal Rheumatoid SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 viral replication significantly significantly lower suppresse therapeutic transgenic mice treated Treatment viral replication while [DOI] 10.1016/j.nantod.2022.101468 [Article Type] Research article
Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection감염 1년 후 헌혈자의 자연적으로 획득되고 기능적인 SARS-CoV-2 항체의 지속성Article Published on 2022-03-182022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] AB0 blood groups Acquired Affect age anti-N antibodies anti-N antibody anti-S antibody antibodies antibody antibody levels antibody production Awareness Blood blood donation blood donor Blood donors Blood Group Cohort Course COVID-19 COVID-19-related symptom declining developmental disease course Europe evaluated FIVE functional groups healthy immune response in vitro individual Infection investigated long-COVID Naturally nine participant produced SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seroprevalence Sex significantly lower spike-protein the disease the viral nucleocapsid vaccination Vaccination Status Viral Year [DOI] 10.3390/v14030637 PMC 바로가기 [Article Type] Article
Persistent SARS-CoV-2 infection in asymptomatic young adultsLetter Published on 2022-03-092022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] activated Analysis antibody Asymptomatic Asymptomatic case CD4 CD8 comparable contribute contributing to correlated dysregulation Evolution of SARS-CoV-2 immune response immune responses Immunocompromised Infection Infectious diseases investigated mechanism memory B Mutation persistent positive regulatory T cells reported SARS-COV-2 infection SARS-CoV-2 RNA significantly lower specific antibody symptomatic symptomatic cases T cell T cells three group upregulation virus Whole-genome sequence [DOI] 10.1038/s41392-022-00931-1 PMC 바로가기 [Article Type] Letter
Novel Synthetic Lipopeptides as Potential Mucosal Adjuvants Enhanced SARS-CoV-2 rRBD-Induced Immune ResponseSARS-CoV-2 rRBD 유도 면역 반응을 향상시키는 잠재적 점막 보조제로서의 새로운 합성 리포펩티드Article Published on 2022-03-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activity adjuvant adjuvants Affect agonist agonists Bacterial BALF candidate vaccine charged residue COVID-19 vaccine CSK cytotoxicity Effect enhanced evaluated exhibited Figuring IgA IgG immune response immunized in vitro induce investigated lipopeptide lipoprotein mimicking mucosal N-terminal nasal novel OVA peptide Potential promote RBD residue response rRBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 rRBD sequence sera serum significantly increased significantly lower Structure Structure-activity relationship suggested Support support vector machine SVM synthetic the SARS-CoV-2 TLR2 Vaccine vaccine adjuvant [DOI] 10.3389/fimmu.2022.833418 PMC 바로가기 [Article Type] Article
Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19IL17의 유전적 연관성과 코로나19에 대한 타액 내 ABO 혈액형 항원의 중요성Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] ABO Activation Analysis Antigen association Blood Group carried caused conducted COVID-19 COVID-19 patient determine Factor FOXP4 FOXP4-AS1 FUT2 General population Genetic genetic association genetic factors genetics genome-wide association Genome-wide association study Genomic analysis Genotype GWAS identify IFNAR2 IL17 IL17A IL17F individual infection with SARS-CoV-2 innate immune response International involved Japan Japanese Meta-analysis mRNA expression nine outbreak Patient presenting replicated reported Respiratory failure risk allele Risk factors Saliva SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severity severity of COVID-19 significantly significantly lower SNP virus worldwide pandemic [DOI] 10.1038/s41598-022-07856-3 PMC 바로가기 [Article Type] Article
Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study미국의 오미크론, 델타 및 알파 SARS-CoV-2 변이체의 covid-19에 대한 mRNA 백신의 임상 중증도 및 효과: 전향적 관찰 연구Observational Study Published on 2022-03-092022-09-11 Journal: The BMJ [Category] SARS, 변종, 임상, [키워드] 95% confidence interval adjusted Alpha Alpha variant calculated case-control study circulating clinical Clinical severity controls delta variant disease severity dose effective Effectiveness group Health Organization hospital Hospital admission Hospital admissions Hospital mortality in-hospital mortality less Lineage morbidity and mortality Mortality mRNA vaccine mRNA vaccines Odds ratio omicron Omicron variant Omicron variants outcome Patient patients predominant Prevent progression prospective observational study provided required SARS-CoV-2 variant Sequencing severe disease severity significantly lower test negative The United States the WHO United States vaccine dose variant variants WHO Clinical Progression Scale whole genome Whole genome sequencing World Health Organization [DOI] 10.1136/bmj-2021-069761 PMC 바로가기 [Article Type] Observational Study
Cardiopulmonary Exercise Performance and Endothelial Function in Convalescent COVID-19 PatientsArticle Published on 2022-03-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Analysis association cardiopulmonary exercise testing cardiovascular diseases chronic disease circulation coronavirus disease correlation COVID-19 disability dysfunction Efficiency end-tidal endothelial Endothelial dysfunction endothelial function exercise Exercise capacity exhibited function independent Linear regressions manifestation mechanism occupational medicine outcome parameters pathogenic Patient performance pharmacological preserved reduced rehabilitation reported SARS-CoV-2 significantly higher significantly lower standardized protocols study population survivor Survivors tension therapeutic option ventilatory [DOI] 10.3390/jcm11051452 PMC 바로가기 [Article Type] Article
In vivo antiviral effect of plant essential oils against avian infectious bronchitis virusResearch Published on 2022-03-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Anti-inflammatory antibody Antibody titer antiviral drug Antiviral effect bronchitis Clinical signs Concentration cytokine cytokine levels dose effective evaluated glycerol GML group groups High dose highest IBV IBV infection IFN-γ IL-4 IL-6 level immune immune function immune response in vivo infection rate Infectious Bronchitis Virus inhibiting inhibition low dose mRNA expression Mutation organ Plant essential oils positive Protective reduced Result significantly significantly higher significantly lower supplementary material Symptom Vaccine viral loads virus virus multiplication [DOI] 10.1186/s12917-022-03183-x PMC 바로가기 [Article Type] Research