Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1Research Article Published on 2013-04-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attenuation C57BL/6 cells changes in conserved coronavirus Deletion different domain Gene Expression growth human diseases in vitro in vivo inhibited mechanism MHV MHV-A59 mice mouse mutant virus positive-sense promoters Region reporter Research responsible reverse genetic system RNA virus shown vaccinia virus was reduced were measured wild-type virus [DOI] 10.1371/journal.pone.0061166 PMC 바로가기 [Article Type] Research Article
Pathogenesis and Tissue Distribution of Avian Infectious Bronchitis Virus Isolate IRFIBV32 (793/B Serotype) in Experimentally Infected Broiler ChickensResearch Article Published on 2012-04-012022-10-29 Journal: The Scientific World Journal [Category] Coronavirus, [키워드] age Antibody titer Broiler bronchitis chicken Clinical sign collected control group demonstrated Depression detected digestive distribution exhibited experimental group indicated Infected Infectious Bronchitis Virus inoculated intranasally isolate kidney lung mild respiratory number of infected oviduct Randomly RNA serotype tissue Trachea two group various tissue viral disease Viral RNA virus virus detection was reduced [DOI] 10.1100/2012/402537 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and ApoptosisResearch Article Published on 2011-10-202022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced [DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article
The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirusResearch Published on 2011-09-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Adsorption After analyzed approach avian coronavirus binding binding activity Cell concerning conditions coronavirus coronavirus S protein cultured cell cultured cells deplete determine different facilitate gastroenteritis IBV Infection intestinal Miller mock-treated mutant mutants parental Plaque assay reduction in Result sialic acid sialic acid binding activity strain Strains t-test TGEV the S protein transmissible gastroenteritis virus treated Treatment virion virus virus was performed was reduced was used [DOI] 10.1186/1743-422X-8-435 PMC 바로가기 [Article Type] Research