‘When will this end? Will it end?’ The impact of the March–June 2020 UK COVID-19 lockdown response on mental health: a longitudinal survey of mothers in the Born in Bradford studyPublic Health Published on 2022-01-112022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, SARS, [키워드] 95% CI Anxiety anxiety disorders assessment association associations cause clinically Cohort studies complex interplay consequence contributing to COVID-19 Depression depression & mood disorders eight employment Ethnic groups Factor Health increase increases in Intervention lack lockdown loneliness magnitude Mental mental health mother objective outcome measure pandemic participant physical activity problem public health question Regression analyses repeated response Result separated Support women worsened worsening [DOI] 10.1136/bmjopen-2020-047748 PMC 바로가기 [Article Type] Public Health
Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2Article Published on 2022-01-112022-10-04 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 receptor binding addition amino-acid cell type cell types cleavage site Cryoelectron microscopy deletion variant domain eight Evolution functional furin recognition motif genetic diversity Host Intra-host diversity modulate molecular Molecular modelling pathology provide RNA virus S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant subpopulation Support trajectory Transmissibility variant viral cell Viral proteins viral variant virus infectivity wild-type [DOI] 10.1038/s41467-021-27881-6 PMC 바로가기 [Article Type] Article
In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike ProteinImmunology Published on 2022-01-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] addition Against antibodies antibody antiviral drug B.1.1.7 B.1.617.2 Bearing binding ability binding energy caused CDRH3 chimeric Comparative conformational flexibility Corticosteroids country COVID-19 COVID-19 patients Delta eight examined expected Fab FIVE form Human Immunotherapy in silico in silico Approach India investigated lineages mAb mAbs molecular docking monoclonal antibody monoclonal antibody (mAb) mutant Mutation neutralization neutralize pandemic Potential Protein question raised Remdesivir S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein stability stable complex strain the SARS-CoV-2 the spike protein These data treat variant variants variants of SARS-CoV-2 wild-type [DOI] 10.3389/fimmu.2021.782506 PMC 바로가기 [Article Type] Immunology
Field epidemiology training programs contribute to COVID-19 preparedness and response globallyResearch Published on 2022-01-102022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] activities activity Analysis Community conducted contribute contributed contributing to country COVID-19 Critical cross-sectional survey description effort eight ENhance epidemiological epidemiologist Epidemiology FETP field Field epidemiology global health global health security Guidance help indicated International Health Regulations Pandemic response pillar plan provide public health public health emergency public health threat qualitative data Quantitative rapid response regions response Result risk Seven supplementary material Surveillance Threats WHO WHO’ World Health Organization’ [DOI] 10.1186/s12889-021-12422-z PMC 바로가기 [Article Type] Research
Development and assessment of novel virtual COVID-19 trainer-of trainers course implemented by an academic–humanitarian partnershipResearch Article Published on 2022-01-102022-10-31 Journal: Global Health Action [Category] COVID-19, COVID19(2023년), SARS, [키워드] average Brown Cohort Community competency conducted coronavirus disease Course COVID-19 COVID-19 pandemic develop development Diagnosis disseminate dissemination domain education effective Effectiveness eight evaluate global health globe health worker healthcare Hope Infection prevention International Intervention knowledge knowledge score Local management mean score objective over p value paired t-test pandemic Participants public health question Region regions Result risk significantly statistically significant stratified Surveillance training university virtual education was collected were used WHO [DOI] 10.1080/16549716.2021.2010391 PMC 바로가기 [Article Type] Research Article
Using a stochastic continuous-time Markov chain model to examine alternative timing and duration of the COVID-19 lockdown in Kuwait: what can be done now?Research Published on 2022-01-082022-10-27 Journal: Archives of Public Health [Category] COVID-19, [키워드] activities Actual incidence Analysis anticipated chain Complete conducted COVID-19 COVID19 deaths declining determine eight Epidemic Hospitalization hospitalizations individual Infection Kuwait lockdown Lockdown duration Lockdown timing management Markov Markov chain occur pandemic recorded reduce reduction in Result SARS-CoV 2 Schools significantly social contact social distancing Spread Stochastic model supplementary material the disease the epidemic Transmission [DOI] 10.1186/s13690-021-00778-y PMC 바로가기 [Article Type] Research
Complex Contact Network of Patients at the Beginning of an Epidemic Outbreak: An Analysis Based on 1218 COVID-19 Cases in ChinaArticle Published on 2022-01-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis caused Characteristics China Cluster Contact Contact network COVID-19 COVID-19 case degree distribution demographic characteristics distribution dynamic network evolution eight Epidemic epidemiological greater Infection infections Infectious disease Interaction Local network network analysis occur Research social network analysis Spread Structure the epidemic trajectory Transmission virus [DOI] 10.3390/ijerph19020689 PMC 바로가기 [Article Type] Article
Not Only High Number and Specific Comorbidities but Also Age Are Closely Related to Progression and Poor Prognosis in Patients With COVID-19Medicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] age cardiovascular disease Characteristics CHB Chinese Chronic Hepatitis B Chronic kidney disease chronic obstructive CKD clinical clinician Comorbidities Comorbidity COPD Coronavirus disease 2019 (COVID-19) correlated correlation Correlation analysis COVID-19 COVID-19 patient COVID-19 patients CVD Diabetes Mellitus died disease Disease progression disease severity eight Factor Fatty liver FIVE Gout group groups hypertension NAFLD Negative conversion number number of comorbidities number of comorbidity Older outcome outcomes patients with comorbidity patients with COVID-19 Poor poor prognosis predict Predictive Prognosis progression pulmonary disease severe COVID-19 patients Specific virus were assessed [DOI] 10.3389/fmed.2021.736109 PMC 바로가기 [Article Type] Medicine
An Insight on the Maternal-Fetal Outcomes of Critically Ill Pregnant Women During the Second Wave of COVID-19Obstetrics/Gynecology Published on 2022-01-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] addition Admission alteration analyzed biochemical Care Cesarean section Cesarean section delivery Clinical characteristics collected Complication complications conducted Coronaviruses COVID-19 COVID-19 progression Critical Critical illness Critically ill deaths demographic data develop disease eight form greater high mortality hospital Hospital stay ICU Ill immune system insight intensive care Intervention invasive ventilation Laboratory less material Mild Moderate COVID-19 Mortality mother Neonatal Neonate Newborn other respiratory infection outcome outcomes parameter Patient patients paucity of data Perinatal care peripartum period physiological Pneumonia postpartum period Pregnancy pregnant patient pregnant women Premature profiles radiological required retrospective second Severe case severe COVID-19 severe COVID-19 patient severe disease significantly significantly higher Stillbirth Stress Transmission undergo United Arab Emirates Wave with COVID-19 women worsening [DOI] 10.7759/cureus.20998 PMC 바로가기 [Article Type] Obstetrics/Gynecology
“More than just a medical student”: a mixed methods exploration of a structured volunteering programme for undergraduate medical studentsResearch Published on 2022-01-032022-10-28 Journal: BMC Medical Education [Category] Coronavirus, SARS, [키워드] analysed approach assessments carried change coded college Complete Contact contributing to correlation COVID-19 pandemic demographics described driven by eight explain explained Factors feature Gender hospitals identity Impact increases in intensity male Medicine modulate outcome participant performed personalised Perspective Quantitative reported response Result Satisfaction School Service learning statistically student supplementary material Transformative learning Volunteer volunteers [DOI] 10.1186/s12909-021-03037-4 PMC 바로가기 [Article Type] Research