SARS-CoV-2 (COVID-19) Vaccine Development and Production: An Ethical Way ForwardSARS-CoV-2(COVID-19) 백신 개발 및 생산: 윤리적인 방법Research Article Published on 2020-06-052022-08-31 Journal: Cambridge Quarterly of Healthcare Ethics [Category] SARS, 신약개발, 임상, [키워드] COVID-19 COVID-19 disease development distribution Efficacy failure Forward Government Health Healthcare system healthy herd immunity Immunity immunization novel vaccines produced recipients reduce SARS-CoV-2 SARS-CoV-2 virus subject Vaccine Vaccine development vaccine testing Vaccines widespread [DOI] 10.1017/S096318012000047X PMC 바로가기 [Article Type] Research Article
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 active malignancy acute respiratory distress syndrome Administered administration age approval approved ARDS assessment automated Berlin blinded Cell cell suspension cellular changes in chronic liver disease class clinical Clinical diagnosis Clinical outcome clinical outcomes clinical trial comparator Compliance conducted control group Controlled trial COVID 19 COVID-19 COVID-19 pandemic declined defined described determine diagnosis of COVID-19 dissemination Donor Dose escalation driving Effect Efficacy element eligible Elizabeth enrolled ethics committee EudraCT excluded facilitate failure fixed dose hospital ICU incidence Inclusion increase in index individual information infusion intensive care unit Intervention Invasive mechanical ventilation investigator King’s College London London Mesenchymal stem cells Mesenchymal stromal cells MHRA moderate Mortality MSC MSCs NIHR number objective open label Other outcome pandemic PaO participant Patient patient population patients with ARDS PCR test PF ratio Phase 1 Phase 2 Placebo placebo-controlled protocol protocol amendment Public randomised randomised controlled trial REC receiving recruited recruitment repair reported Research respiratory Resuscitation Sample size secondary Secondary objective Secondary outcomes Serious Adverse Events severe ARDS single intravenous infusion SOFA solution Standard steering committee stratified stromal cell Study protocol Therapeutics therapy trauma Treatment Trial triple blinded Trust umbilical United Kingdom university Venous Thromboembolism Ventilation verbal Volume web-based randomisation system website WHO Withdrawal [DOI] 10.1186/s13063-020-04416-w PMC 바로가기 [Article Type] Letter
Acute Renal Failure in Critically Ill COVID-19 Patients With a Focus on the Role of Renal Replacement Therapy: A Review of What We Know So FarInternal Medicine Published on 2020-06-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute renal failure Care continuous renal replacement therapy (crrt) coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critically ill Critically ill patient cytokine decrease deteriorate develop failure focus help ICU Ill Infection intensive care management Mortality multifactorial nephrotoxic pathophysiology Patient patient population patients renal renal failure renal replacement therapy replacement Research review role septic patient Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Support supportive care the disease therapy Treatment Volume [DOI] 10.7759/cureus.8429 PMC 바로가기 [Article Type] Internal Medicine
A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 48 hour Admission allergic reaction anticipated application AST/ALT Bacterial infection Bacterial infections blinded block Breast feeding clinical clinical trial Combination concealed conducted Contraception Control COVID-19 COVID-19 patient criteria defined dependent on Desirable diagnostic Diaphragm dissemination dose double blind ECMO Efficacy Efficacy and safety element Endpoint evaluate extracorporeal membrane oxygenation failure female Germany Hospital stay Hydroxychloroquine IL-6-Rezeptor blockade Immunosuppression immunosuppressive therapy IMV independent Inflammation ingredient Injury Inpatient intensive care units interfere Invasive mechanical ventilation investigator investigators less life lung failure mechanical ventilation methotrexate NaCl NIV non-invasive ventilation number objective outcome parallel group parameters participant Participation Pathogenesis Patient patients PCT performed placebo-controlled trial Pneumonia polymerase chain positive Prednisolone produced progression proof protocol Pulmonary function pulmonary inflammation Quality of life randomisation randomised randomised controlled trial recruited reduce Registered respiratory Safe Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection SAS severe COVID-19 Severe COVID-19 pneumonia Simultaneous single dose status stratified Study protocol sulfasalazine System the patient therapy Tocilizumab Treatment Trial trials Tuberculosis ULN unit Ventilation ventilator ventilator free day ventilator free days VFD Viral hepatitis website [DOI] 10.1186/s13063-020-04447-3 PMC 바로가기 [Article Type] Letter
Acute Respiratory Failure Secondary to COVID-19 Viral Pneumonia Managed With Hydroxychloroquine/Azithromycin TreatmentAnesthesiology Published on 2020-05-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute respiratory failure Admission age Antiviral treatment Azithromycin Cancer Case report center cerebrovascular accident Chest Combination Comorbidities coronavirus disease COVID-19 Day Department Diabetes Mellitus Effectiveness Evidence failure highest Hydroxychloroquine hypertension ICU intensive care unit intubation lung male Mortality neurological deficits New York patchy Patient positive provide respiratory Respiratory failure returned risk secondary to Septic shock significantly sputum state tomography university Vaccine Vascular Viral pneumonia [DOI] 10.7759/cureus.8268 PMC 바로가기 [Article Type] Anesthesiology
COVID-19 in the UK and Occupational Health and Safety: Predictable not Inevitable Failures by Government, and Trade Union and Nongovernmental Organization ResponsesComment and Controversy Published on 2020-05-252022-10-29 Journal: New Solutions [Category] COVID-19, MERS, SARS, [키워드] agency Care COVID-19 COVID-19 pandemic equipment European failure Government hazards Health health care workers International knowledge occupational offered organization outlined pandemic response risk threat Trade UK UK Government union virus [DOI] 10.1177/1048291120929763 PMC 바로가기 [Article Type] Comment and Controversy
COVID-19 Interference with Renin-Angiotensin System in the Context of Heart FailureLetter to the Editor Published on 2020-05-222022-10-29 Journal: mBio [Category] Coronavirus, MERS, SARS, [키워드] Context COVID-19 failure heart Interference System [DOI] 10.1128/mBio.00946-20 PMC 바로가기 [Article Type] Letter to the Editor
Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic EvidenceReview Published on 2020-05-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2, acute kidney injury affected basic blood pressure catepsin clinical Comprehensive coronavirus coronavirus disease cough COVID COVID-19 COVID-19 patient Cytokine storm Diabetes Mellitus Endothelium event Evidence failure Fever heparin Hypothesis include Kawasaki disease Kidney disease neurologic disorders organ Patient reported Shortness of breath Symptom systemic manifestations Venous Thromboembolism virus [DOI] 10.3390/jcm9051417 PMC 바로가기 [Article Type] Review
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent PlasmaResearch Published on 2020-04-282022-11-01 Journal: JAMA [Category] COVID-19, SARS, [키워드] acute respiratory distress acute respiratory syndrome Administered administration Admission age Antiviral antiviral agent Antiviral treatment approach ARDS assessment binding blood biochemical body temperature case sery change China Chinese patient clinical Clinical outcome clinical status clinical trials conducted convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Critically ill patient determine Dilution discharged ECMO Effectiveness ELISA end point enzyme-linked immunosorbent exposure extracorporeal membrane oxygenation failure Final finding Follow-up greater hospital Human plasma IgG Ill Importance Infection Infectious disease laboratory-confirmed limited sample size measure mechanical ventilation Methylprednisolone Mortality neutralization titer neutralizing antibody Neutralizing antibody titer normalized objective observation outcome pandemic participant Patient patients plasma Plasma transfusion Point preliminary finding progression raise randomized clinical trials receiving recovered patients Relevance resolved Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2–specific antibody serum antibody setting severe pneumonia Shenzhen SOFA SOFA score Study design Support syndrome therapeutic agent treated Treatment ventilatory Viral load were given with COVID-19 women [DOI] 10.1001/jama.2020.4783 PMC 바로가기 [Article Type] Research
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome as a Presentation of Coronavirus Disease 2019Emergency Medicine Published on 2020-04-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] av nodal blockers blockade bradycardia brash syndrome Coronavirus disease 2019 COVID-19 end-organ damage failure global pandemic hyperkalemia novel coronavirus disease predominant presentation renal renal failure Respiratory failure sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Shock syndrome triggered while [DOI] 10.7759/cureus.7816 PMC 바로가기 [Article Type] Emergency Medicine