Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 CellsArticle Published on 2017-07-262022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation Ammonium Analysis Apoptosis apoptosis induction apoptotic blocked bronchitis caspase Caspases caused Cell cells cellular chicken chicken macrophage chloride CPE Cytopathic effect Efficacy expression extrinsic pathway flow cytometry IBV IBV infection Immune cell immune cells Infection Infectious Bronchitis Virus inhibited inhibitory intrinsic Macrophage macrophage cell line mammalian cell mechanism morphological changes offer previous study primary cells Replication reported Research suggested viability virus replication was increased [DOI] 10.3390/v9080198 PMC 바로가기 [Article Type] Article
Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their BioengineeringArticle Published on 2017-06-302023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Antitumor bioengineering chemokines immune cells Scaffolds [DOI] 10.3389/fimmu.2017.00767 PMC 바로가기
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
Neuroimmune Interaction in the Regulation of Peripheral Opioid-Mediated Analgesia in InflammationArticle Published on 2016-08-022023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] immune cells Inflammation neuroimmune opioids Pain Peripheral nervous system [DOI] 10.3389/fimmu.2016.00293 PMC 바로가기
Low Frequency of Peripheral Lymphocyte in Chronic Hepatitis B Patients Predicts Poor Progression to Hepatocellular CarcinomaArticle Published on 2016-05-012023-06-19 Journal: Journal of Clinical Laboratory Analysis [Category] B형 간염, [키워드] CHB HCC immune cells lymphocytes. [DOI] 10.1002/jcla.21838 PMC 바로가기
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력Research Article Published on 2016-03-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Affect Analysis anti-neutrophil cytoplasmic antibody association Autoimmune Autoimmune diseases blood cell blood vessel blood vessels bowel Cancer cell types cellular cellular activation clinical disease complex complex system contribute cytoplasmic damage database dependent on disease risk disease-associated loci DNA Effect eQTL eQTL analysis eQTL mapping eQTLs estimate examined Examining expression expression data expression quantitative trait loci FIVE Gene Expression Genetic genetic control Genetic studies Genetic variant genetic variants genetics Genome-wide association studies Gut GWAS healthy healthy control healthy controls help Human immune system human inflammatory diseases identifying immune Immune cell immune cell type immune cells immune-mediated diseases in vitro include Infection Inflammation Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases insight investigated joint knowledge leucocyte loci majority mapping Multiple observation Pathogenesis Patient performed proportion PROTECT provide Quantitative regions resulting risk specificity subset subtype tissue tissues Treatment Type variant Vasculitis White blood cell [DOI] 10.1371/journal.pgen.1005908 PMC 바로가기 [Article Type] Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinomaReview Published on 2011-10-142023-06-09 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] cytokine Genotype Hepatitis B virus Hepatocellular carcinoma immune cells Mutation Prognosis signaling pathway Viral load. [DOI] 10.3748/wjg.v17.i38.4258 PMC 바로가기 [Article Type] Review
Pathogenetic mechanisms of severe acute respiratory syndromeArticle Published on 2007-09-072022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while [DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article