Infection importation: a key challenge to malaria elimination on Bioko Island, Equatorial Guinea감염 유입: 적도 기니 비오코 섬에서 말라리아 퇴치의 주요 도전 과제Research Published on 2015-02-052024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Elimination importation malaria Migration Travel [DOI] 10.1186/s12936-015-0579-5 PMC 바로가기 [Article Type] Research
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
Malarial pigment hemozoin impairs chemotactic motility and transendothelial migration of monocytes via 4-hydroxynonenalarticle Published on 2014-10-312024-09-01 Journal: Free Radical Biology and Medicine [Category] 말라리아, [키워드] 4-hydroxynonenal Actin Coronin Free radicals Hemozoin lipoperoxidation malaria Migration monocyte [Article Type] article
Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ( IFNL4 )개선된 바이러스 제거와 관련된 변이체에 대한 선택은 인터페론 람다 4(IFNL4)의 국소적 적응형 가성화를 유도합니다.Research Article Published on 2014-10-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABC adaptive allele America Antiviral antiviral activity approach Approximate Asia Asian association Bayesian clearance complex conserved disease drive driving East Elimination ENCODE environmental force Europe European Evidence evidence of fixation Frame Frequency functional Genetic genetic association Genetic variant Genetic variation groups HCV hepatitis C hepatitis C virus heterogeneity Human human populations IFN-λ IFNL4 Improved inactivation Infection insertion Interferon lambda Lambda mammal mammals Migration moderate Mutation Open reading frame phenotype phenotypic diversity Population populations positive Positive selection Protein provide pseudogene raise raising reached resulting Selection selective SNP SNPs strength susceptibility the strongest turn variant virus [DOI] 10.1371/journal.pgen.1004681 PMC 바로가기 [Article Type] Research Article
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelinationResearch Published on 2014-08-202022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] Affect Anti-viral immune response approved CD4+ CD8+ T cell Central nervous system clinical disease CNS correlated cytokine production cytolytic Demyelination disease disease severity disease-causing dose drug Effect effective examined exhibited expression flow cytometry food FTY720 IFN-γ infiltration Inflammatory inhibiting Lymph node lymphocyte mice Migration modulate morbidity and mortality Mortality mouse hepatitis virus multiple sclerosis Neuroinflammation neurologic neurotropic not affect occur Patient Post-infection proliferation recorded reduce reduction in Result S1P receptor severity staining T lymphocyte T lymphocytes Therapeutic benefit TNF-α treated Treatment viral replication viral-induced virus virus-specific T cell was determined were infected [DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research
Visualizing T Cell Migration in situReview Article Published on 2014-07-292023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] CD8 T cells Imaging techniques infections intravital microscopy Migration T cells [DOI] 10.3389/fimmu.2014.00363 PMC 바로가기 [Article Type] Review Article
Integrating rapid risk mapping and mobile phone call record data for strategic malaria elimination planning신속한 위험 맵핑과 모바일 전화 통화 기록 데이터를 통합한 전략적 말라리아 제거 계획Research Published on 2014-02-102024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Disease mapping human mobility Malaria elimination Migration mobile phones Plasmodium falciparum malaria satellite imagery Spatial analysis [DOI] 10.1186/1475-2875-13-52 PMC 바로가기 [Article Type] Research
Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008Article Published on 2013-11-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Influenza Migration persistence phylogeography Tropics Vietnam viruses [DOI] 10.3201/eid1911.130349 PMC 바로가기
MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitisResearch Article Published on 2013-10-242022-10-28 Journal: ASN NEURO [Category] Coronavirus, [키워드] accumulate BBB, blood brain barrier Blood brain barrier CD4 CD4 T cells CD8 Central nervous system chemokine CNS CNS, Central Nervous System coronavirus decrease disease severity EAE, experimental autoimmune encephalitis Encephalitis expression facilitate Glia glia limitans IFNγ, interferon γ IFNγ induce Infection Infectious virus Inflammatory response interferon γ limitans mAb, monoclonal antibody matrix metalloproteinase matrix metalloproteinases MHV, mouse hepatitis virus mice Migration MMP, matrix metalloproteinase neurotropic not affected Pathogenesis perivascular perivascular cuff PFA, paraformaldehyde recruitment reduced responsible suggested T cell T cell subset T cells TIMP-1 TIMP, tissue inhibitor of matrix metalloproteinases tissue damage Tissue Inhibitor virus WT, wild-type [DOI] 10.1042/AN20130033 PMC 바로가기 [Article Type] Research Article
Profile: Manhica Health Research Centre (Manhica HDSS)만히카 보건 연구 센터 (만히카 HDSS)journal-article Published on 2013-10-012024-07-30 Journal: International Journal of Epidemiology [Category] 말라리아, 살모넬라증, 세균성이질, [키워드] cause of death Fertility HDSS Health Households Migration morbidity Mortality Population Rural Southern Mozambique [DOI] 10.1093/ije/dyt148 [Article Type] journal-article