proteomics – Page 32 – Communicable Diseases Research

A serum proteome signature to predict mortality in severe COVID-19 patients

Research Article

Published on 2021-07-052022-10-30
Journal: Life Science Alliance [Category] COVID-19, SARS,

Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV-2 Viral Antigen and to Study Host Response

SARS-CoV-2 바이러스 항원 검출 및 숙주 반응 연구를 위한 COVID-19 환자의 소변 질량 분광 분석

Article

Published on 2021-07-022022-09-11
Journal: Journal of Proteome Research [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] acute phase response Affect alteration Amino acid amino acid transporter Analysis approach body fluid body fluids Brain capture Chain Reaction complement complement system coronavirus COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients Culture detect detection diagnosed Glucose immune response in urine Infection involved Kidney function kidneys liver Lungs mass mass spectrometry microbial Nasopharyngeal swab nasopharyngeal swabs NPHS2 nucleocapsid protein organ Pathogenesis pathogenesis of COVID-19 peptide peptides polymerase chain polymerase chain reaction positive Protein proteome proteomic proteomics public health Quantitative quantitative proteomic analysis Regulation renal response reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 positive individual SARS-CoV-2 positive individuals SLC36A2 SLC5A10 sodium subset transcriptase Urine Viral Viral antigen viral antigens Viral RNA virus were used
[DOI] 10.1021/acs.jproteome.1c00391 PMC 바로가기 [Article Type] Article

KEA3: improved kinase enrichment analysis via data integration

AcademicSubjects/SCI00010

Published on 2021-07-022022-10-31
Journal: Nucleic Acids Research [Category] COVID-19, SARS,

[키워드] cellular co-expression co-occurrence collected database enrichment enrichment analysis examined expected experiment experiments Gene Expression IMPROVE Interaction kinase Phosphoproteomics phosphorylated predict predicted Proteins proteomics responsible Signaling Small molecules substrate supported upstream
[DOI] 10.1093/nar/gkab359 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Identification of Proteomic Signatures in Chronic Obstructive Pulmonary Disease Emphysematous Phenotype

Original Research

Published on 2021-07-012024-09-02
Journal: Frontiers in Molecular Biosciences [Category] 대상포진,

[키워드] chronic obstructive pulmonary disease DHRS9 emphysematous phenotype KRT17 proteomics
[DOI] 10.3389/fmolb.2021.650604 PMC 바로가기 [Article Type] Original Research

SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes

Article

Published on 2021-07-012023-07-02
Journal: The Journal of Clinical Investigation [Category] SARS,

[키워드] COVID-19 fibrosis Infectious disease proteomics Pulmonary surfactants
[DOI] 10.1172/JCI148635 PMC 바로가기

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity

SARS-CoV-2에 감염된 햄스터 폐 조직의 정량적 단백질체학은 질병 발병기전 및 중증도에 영향을 미치는 숙주 인자를 나타냅니다

Article

Published on 2021-07-012022-09-11
Journal: FASEB journal : official publication of the Federa [Category] SARS, 유전자 메커니즘,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar damage Analysis carried clinical parameter Clinical parameters coagulation cascade complement convalescence coronavirus COVID-19 COVID-19 patient COVID-19 patients DAD differential expression differentially expressed differentially expressed proteins Diffuse alveolar damage effort enriched pathways evaluate expression Factor Ferroptosis groups hamster hamsters histopathological Host in vivo infected with SARS-CoV-2 involved isolates Local lung Lung function Lung pathology lung proteome lung tissue lung tissues mass spectrometry Mesocricetus Orbitrap Pathogenesis pathological change pathophysiological Pathway analysis platelet activation Post-infection progression protective role Protein proteomic proteomics Pulmonary Surfactant Quantitative reported resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity SFTPB SFTPD significantly surfactant Syrian golden hamster Syrian Golden hamsters the disease tissue sample tissue samples
[DOI] 10.1096/fj.202100431R PMC 바로가기 [Article Type] Article

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

결합 된 대사 활성화 제는 온화한 중등도의 CovID -19에서 회복을 가속화합니다

Clinical Trial

Published on 2021-06-282022-08-13
Journal: Advanced Science [Category] MERS, 임상,

[키워드] accelerate activator adenine administration ambulatory patient ambulatory patients Amino acid antioxidant antioxidant metabolism changes Clinical data clinical trial CMAs Combined combined metabolic activator combined metabolic activators complete recovery comprehensive analysis conducted COVID‐19 COVID‐19 patients deficiencies deficiency double‐blinded phase effective glutathione glutathione metabolism immune response IMPROVE include Infection Inflammation inflammatory proteomics investigated l ‐carnitine l ‐carnitine tartrate lead lipid metabolism metabolic metabolic abnormalities metabolic function metabolism metabolite metabolites metabolomics mitochondrial mitochondrial dysfunction mixture NAD+ nicotinamide nicotinamide adenine dinucleotide nicotinamide riboside omics data Open‐label phase Patient patients treated Phase 2 phase 3 trial Phase 3 trials phase‐2 phase‐3 Placebo placebo group Placebo‐controlled Plasma level Plasma levels plasma metabolome plasma metabolomics precursor Protein proteome proteomics regulate respiratory respiratory problems reveal Safe salt shown significantly significantly shorter therapeutic regime therapeutic strategy Treatment
[DOI] 10.1002/advs.202101222 PMC 바로가기 [Article Type] Clinical Trial

Recent Progress in Metabolic Syndrome Research and Therapeutics

Review

Published on 2021-06-252022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome affected approach cellular Characteristics Comprehensive consequence contributed coronavirus differentially expressed disease entity dysregulation energy metabolism facilitate gut microbiota heterogeneity homeostasis Host Impact incidence Infection inflammatory status inquiry mandatory measure mechanism metabolic metabolic parameters metabolic syndrome metabolites metabolomics microbiota molecular pathogenic mechanisms phenotype physical activity Population Precision precision medicine Progress Protein proteomics recent risk SARS-CoV-2 signaling pathway therapeutic Therapeutics Therapies Variation
[DOI] 10.3390/ijms22136862 PMC 바로가기 [Article Type] Review

Serum biomarker discovery related to pathogenesis in acute coronary syndrome by proteomic approach

Article

Published on 2021-06-252023-08-29
Journal: Bioscience Reports [Category] E형 간염,

[키워드] Acute coronary syndrome Biomarkers Pathogenesis proteomics
[DOI] 10.1042/BSR20210344 PMC 바로가기

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity

제2형 당뇨병 응고병증 단백질은 COVID-19 심각성을 반영하는 바이오마커와 충돌할 수 있습니다

Endocrinology

Published on 2021-06-252022-09-11
Journal: Frontiers in Endocrinology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Analysis aptamer baseline Biomarker Biomarkers blood glucose change changed changes in clinical Coagulation coagulation cascade coagulation factor Cohort cohort of patient complement condition conflict Control controls COVID-19 COVID-19 disease COVID-19 severity Critical degranulation demonstrated disease disease severity euglycemia factor IX Glucose heparin hypoglycemia induced Kininogen neutrophil normoglycemia objective other conditions patients Platelet predict Protein proteomic Proteomic analysis proteomics Registration Result severity of COVID-19 slow suggested T2D Thrombospondin Type type 2 diabetes Vitamin vitamin K was performed were measured
[DOI] 10.3389/fendo.2021.658304 PMC 바로가기 [Article Type] Endocrinology