registry

[키워드] 1:1 Acetylcysteine Activation Acute respiratory infection addition Admission All participant All participants antioxidant effect antioxidant effects appearance approved Arm assigned Bandar Abba Bandar Abbas baseline Blinding block randomization Care caused cell damage clinical clinical condition clinical trial clinical trials Committee comparator Comparator group composite endpoint control group Controlled clinical trial COVID-19 discharge dissemination dose Effects Efficacy element ethics committee evaluate excluded expected FIVE Health Health care help Hospitalization hypersensitivity Hypoxemia infiltration inflammatory factors injection intensive care intensive care unit Intervention intervention group Intravenous injection investigator Lactate lactate dehydrogenase LDH lead Local lung lung failure lymphopenia mechanical ventilation Medical Science Medical Sciences medication minute N-acetylcysteine number objective outcome oxygen oxygen partial pressure parallel-group partial pressure participant Patient patients Pharmaceutical Company Phase 3 Placebo positive PCR test Pregnancy primary endpoint principal investigator Progressive protocol random randomised randomised controlled trial randomization Randomized Randomly reactive oxygen species receive recruitment Registered registry reported respiration rate respiratory infection Saline Sample size SARI SARS-CoV-2 virus sequence severe COVID-19 severe COVID-19 patient severe COVID-19 patients Side effect Standard Standard of care Sterile sterile water Study protocol supplementary material technology test results the ethics committee the patient the SARS-CoV-2 virus Treatment Trial registration university water water for injection website were measured written consent
[DOI] 10.1186/s13063-021-05242-4 PMC 바로가기 [Article Type] Letter