Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model피내 전달 DNA 백신은 붉은털 원숭이 SARS-CoV-2 챌린지 모델에서 바이러스 부하 감소를 매개하는 내구성 면역을 유도합니다Article Published on 2021-09-282022-09-12 Journal: Cell Reports Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] Abstract adaptive immune system ADCD ADCP anti-SARS-CoV-2 Antigen Arm caused cellular challenge clinical trials clinically coronavirus Coronavirus disease 2019 COVID-19 COVID-19 disease DNA vaccine Efficacy Electroporation evaluated humoral humoral immune response ID DNA vaccine immune immune response Immunity immunization induce Infectious disease INO-4800 lung macaque neutralized neutralizing antibody responses protection Protective pseudotype viruses public health RBD binding antibody recall reduced viral load reduction in regimen respond response resulting rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 spike Spike protein Support the SARS-CoV-2 the SARS-CoV-2 virus vaccination vaccine dose Viral load [DOI] 10.1016/j.xcrm.2021.100420 PMC 바로가기 [Article Type] Article
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants교차 중화 항체는 SARS-CoV-2 잠복 부위에 결합하고 순환 변이체에 저항합니다Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affinity antibodies antibody Antibody therapeutics causative agent circulating SARS-CoV-2 variants circulating variant conserved COVID-19 COVID-19 pandemic cross-neutralizing antibody crystal structure crystal structures disrupt domain epitope Epitopes global effort global efforts isolates Mutation N-terminal domain neutralize Neutralizing antibodies public health RBD Receptor-binding domain recognize sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants several variant several variants the RBD the receptor-binding domain Vaccines variants of SARS-CoV-2 Viral viral infection viral spike virus variants X-ray crystallography [DOI] 10.1038/s41467-021-25997-3 PMC 바로가기 [Article Type] Article
Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses다에피토프 및 교차 반응성 체액 중화 및 세포 CD4 및 CD8 반응을 유도하는 SARS-CoV-2에 대한 합성 펩타이드 백신의 전임상 평가Research Article Published on 2021-09-272022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] adjuvant alum Amino acid antibody Antibody Response B-cell epitopes BALB/c CD4 CD8 cellular cellular immunity characterization CpG cross-reactive cysteine cysteines displaying dose epitope epitope mapping Epitopes experiment Freund’s Freund’s adjuvant generate hACE2 HLA humanized humoral identification identify immunization infected individual infected individuals K18-hACE2 mice lethal dose linear epitope linear epitopes mice Neutralizing Neutralizing antibodies neutralizing capacity overlapped peptide peptide vaccine peptides Preclinical Protein Proteins RBD Receptor-binding domain recognizing response S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants sera subunit suggested T-cell epitopes tested the receptor-binding domain titres transgenic mice vaccination Vaccine vaccine platform [DOI] 10.1080/22221751.2021.1978823 PMC 바로가기 [Article Type] Research Article
Assessment of adjuvantation strategy of lipid squalene nanoparticles for enhancing the immunogenicity of a SARS-CoV-2 spike subunit protein against COVID-19코로나19에 대한 SARS-CoV-2 스파이크 소단위 단백질의 면역원성을 향상시키기 위한 지질 스쿠알렌 나노입자의 면역보강 전략 평가Article Published on 2021-09-252022-09-12 Journal: International journal of pharmaceutics [Category] MERS, SARS, 진단, [키워드] Administered aluminum assessment comparable coronavirus disease COVID-19 COVID-19 vaccine cytokine dose effective intervention Efficacy ELISA enhancing the immunogenicity group histological examination IgG IL-10 immune response immunomodulation induce information injection interferon intramuscularly investigated Lipid Lipid squalene nanoparticles mice modulating Neutralizing pandemic Protective antibody Protein S-protein SARS-CoV-2 spike secretion serum sample significantly Single injection splenocytes subunit the SARS-CoV-2 the vaccine Vaccine vaccine adjuvant vaccine injection virus [DOI] 10.1016/j.ijpharm.2021.121024 PMC 바로가기 [Article Type] Article
Peptides Derived From S and N Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Induce T Cell Responses: A Proof of Concept for T Cell VaccinesMicrobiology Published on 2021-09-242022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome administration alleviate CD8 concept coronavirus coronavirus 2 CTL cytotoxic T lymphocyte dose-dependent manner effective effector memory elicit epitope hamster highlight human ACE2 immunization in vivo increase indicated induce interferon-γ mice neutralizing antibody nucleocapsid protein peptide peptide vaccine Peptide vaccines peptides proof proportion Pulmonary pathology reduce respiratory response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike significantly statistically significant T cell T cell response T cell responses T cells target cell the SARS-CoV-2 transgenic mice tumor necrosis factor-α Vaccine variant viral titer virus [DOI] 10.3389/fmicb.2021.732450 PMC 바로가기 [Article Type] Microbiology
Association of total and neutralizing SARS-CoV-2 spike -receptor binding domain antibodies with epidemiological and clinical characteristics after immunization with the 1 st and 2 nd doses of the BNT162b2 vaccineBNT162b2 백신의 1차 및 2차 접종 후 역학 및 임상 특성을 갖는 총 및 중화 SARS-CoV-2 스파이크 수용체 결합 도메인 항체의 연관성Article Published on 2021-09-242022-09-11 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] age antibody antibody levels association binding domain BMI BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 vaccine Clinical characteristics clinical parameter Clinical parameters Cohort correlation COVID-19 COVID-19 vaccine dose elicited epidemiological females Final groups healthcare worker Immunity immunization Immunosuppressive medication immunosuppressive medications IQR median NAbs negatively affected Neutralizing Neutralizing antibodies neutralizing antibody Older age participant positive Protective Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein second dose significant difference smoking Spearman spike Spike protein statistical analysis statistically significant systemic adverse event systemic adverse events the vaccine vaccine dose vaccine doses was performed [DOI] 10.1016/j.vaccine.2021.07.067 PMC 바로가기 [Article Type] Article
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope초강력 범-β-코로나바이러스 계통 B(β-CoV-B) 중화 항체는 보존된 에피토프를 표적으로 하여 닫힌 형태로 수용체 결합 도메인을 잠급니다Research Article Published on 2021-09-232022-09-10 Journal: Protein & Cell [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 binding ACE2 binding site administration Analysis antibody antibody-dependent cell-cell fusion antigenic binding binding antibody cell-cell fusion circulating variant circulating variants competing conserved cross-reactivity develop domain effective epitope Epitopes family member family members highlight in vivo induce Lineage neutralize neutralizes neutralizing antibody neutralizing epitope neutralizing epitopes New protective vaccine RBD Receptor-binding domain Recognition recognize reduced SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARSr-CoV WIV1 supplementary material the RBD the receptor-binding domain therapeutic therapeutic antibodies therapy threat unique Vaccine design XG005 XG014 β-coronavirus [DOI] 10.1007/s13238-021-00871-6 PMC 바로가기 [Article Type] Research Article
One-Step, Wash-free, Nanoparticle Clustering-Based Magnetic Particle Spectroscopy Bioassay Method for Detection of SARS-CoV-2 Spike and Nucleocapsid Proteins in the Liquid Phase액상에서 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 검출을 위한 원스텝, 무세척, 나노입자 클러스터링 기반 자기 입자 분광법 생물검정 방법Article Published on 2021-09-222022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding bioassay Biomarker Biomarkers cause changes in Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable detection Detection limit diagnostic Diagnostic method disease disease diagnostics Disease surveillance ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Epidemic functional global pandemic group in sight intrinsically liquid magnetic nanoparticle Magnetic particle spectroscopy measure Medical resources MNP MONITOR MPS nanoparticle nucleocapsid nucleocapsid protein Nucleocapsid proteins pandemic Particle phase platform polyclonal antibodies polyclonal antibody qRT-PCR qualitative detection Quantitative quantitative reverse transcription-PCR Region response reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus sight Spectroscopy spike Spike protein Surveillance the disease Traditional variety [DOI] 10.1021/acsami.1c14657 PMC 바로가기 [Article Type] Article
Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary StudyArticle Published on 2021-09-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] addition age ambulatory anti-inflammatory activity antiviral activity Antiviral agents Asymptomatic binding cationic cells chronic conditions COVID-19 COVID-19 patients disorders Efficacy explained favor first dose glycoprotein individual Innate immunity Interaction iron homeostasis lactoferrin moderate morbidity and mortality obese Patient patients pleiotropic Proteoglycan reduction in required Retrospective study Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 variants significantly lower single-stranded RNA virus symptomatic Symptoms therapy treated patients Treatment Vaccine [DOI] 10.3390/jcm10184276 PMC 바로가기 [Article Type] Article
Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위420 Published on 2021-09-212022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant animals antibody Antibody titers B.1.351 betacoronaviruses breadth CD4+ T cell Cellular immune response cellular response Cellular responses concerning coronavirus Coverage COVID-19 vaccine cross-neutralization activity displaying domain Efficacy eight elicit emergence evaluate ferritin Formulation High-dose highlighting humoral Humoral and cellular immune responses immune responses Immunity lower airway macaque macaques nanoparticle Neutralizing pandemic potency PROTECT Protein QS-21 Rapid receiving Receptor-binding domain reduce Replication respiratory respiratory tract response robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serum neutralizing antibody Seven severe acute respiratory syndrome Coronavirus Significance Spike protein Support T cell T cell responses Th1 the receptor-binding domain the Sarbecovirus the SARS-CoV-2 two-dose regimen undetectable upper and lower airways vaccination Vaccine Vaccine development variant Viral viral replication VoC VOCs WA1/2020 [DOI] 10.1073/pnas.2106433118 PMC 바로가기 [Article Type] 420