Optimization of COVID-19 vaccination and the role of individuals with a high number of contacts: A model based approachResearch Article Published on 2022-03-082022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] approach average Brazil calibrated compose Contact country COVID-19 incidence COVID-19 pandemic COVID-19 vaccination death Effectiveness Evidence greater Health services hypothetical individual lack optimization Portugal recovered reduction in resource social isolation symptomatic vaccination Vaccination strategies [DOI] 10.1371/journal.pone.0262433 PMC 바로가기 [Article Type] Research Article
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection증상이 있는 SARS-CoV-2 알파 감염이 있는 백신 접종 환자의 적응 면역 반응Article Published on 2022-03-082022-09-11 Journal: JCI Insight [Category] MERS, SARS, 변종, 진단, [키워드] Adaptive immunity Alpha Alpha variant antibody antibody levels Antibody titers Breakthrough infection breakthrough infections caused Cellular immune response cellular immune responses characterized Cohort COVID-19 declined defined disease ELISA Genetic variation HCs healthy control IFN-γ IgG antibody IgG antibody titers IgG titer IgG titers immune immune response immune responses infected patient infected patients Infection Infectious disease mRNA vaccination neutralization activity Neutralizing neutralizing antibody Patient protective immunity response SARS-CoV-2 SARS-CoV-2 vaccination severe disease sustained symptomatic symptomatic infection symptomatic infections symptomatic patient Symptomatic patients T cell T cell response T cell responses the SARS-CoV-2 the vaccine vaccination Viral viral variant Viral variants virus Virus neutralization virus-specific T cell [DOI] 10.1172/jci.insight.155944 PMC 바로가기 [Article Type] Article
The role of tumor necrosis factor alpha − 308A > G polymorphism on the clinical states of SARS-CoV-2 infectionResearch Published on 2022-03-072022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 95% CI A allele acute respiratory syndrome Affect allele Alpha Asymptomatic coronavirus Coronavirus infections country COVID-19 COVID-19 patients cytokine Defense described determine expression form G allele Genotype Host include increase individual mechanism Mild Mutation Necrosis pathogenesis of COVID-19 patients polymorphism Polymorphisms presenting promoter region Result risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 single-nucleotide subject Symptom symptomatic Symptomatic patients symptoms of COVID-19 the disease TNFα transcriptional activity tumor necrosis tumor necrosis factor alpha was used [DOI] 10.1186/s43042-022-00274-0 PMC 바로가기 [Article Type] Research
Preventing a cluster from becoming a new wave in settings with zero community COVID-19 casesResearch Article Published on 2022-03-072022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] accumulating Affect applied average behavioural Cluster Community community transmission Containment strategy controls COVID-19 COVID-19 case defined downstream Factors growth highlighting increase in International management mandatory Mask modeling new SARS-CoV-2 outbreak Outbreaks per day Preventing Probability random reached reduce Result resulting risk supplementary material symptomatic Trajectories Travel Victoria [DOI] 10.1186/s12879-022-07180-1 PMC 바로가기 [Article Type] Research Article
Risk Factors Associated With COVID-19 Symptoms and Potential Vertical Transmission During Pregnancy: A Retrospective Cohort StudyObstetrics/Gynecology Published on 2022-03-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Asymptomatic biochemical BMI body mass index Characteristics collected conducted cough COVID-19 COVID-19 pandemic COVID-19 severity COVID-19 symptom Deleterious demonstrated disease severity Evidence Factor Fever Health highest hypokalemic impacted investigated Laboratory lowest Mortality Newborn obesity objective observé outcome outcomes overweight placental positive Potassium Potential Pregnancy pregnant pregnant women Public Hospital Research Result retrospective cohort study SARS-CoV-2 Screening statistically significant Symptom symptomatic tested Transmission vertical virus with COVID-19 women [DOI] 10.7759/cureus.22900 PMC 바로가기 [Article Type] Obstetrics/Gynecology
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B2R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Digital healthcare in COPD management: a narrative review on the advantages, pitfalls, and need for further researchReview Published on 2022-03-022022-10-29 Journal: Therapeutic Advances in Respiratory Disease [Category] Coronavirus, SARS, [키워드] attrition Care chronic chronic disease Clinicians COPD COVID-19 Digital Digital health effective Efficacy exacerbations expand hcp Health healthcare Healthcare professional Healthcare system Healthcare systems help implementation IMPROVE improve clinical outcome inhaler technique machine learning management morbidity and mortality Obstructive offer Pathways Patient Patient care patient engagement patients pulmonary disease pulmonary rehabilitation reduced Regulatory Research resource Self-management smoking Support symptomatic training videos treatment strategy understanding variety [DOI] 10.1177/17534666221075493 PMC 바로가기 [Article Type] Review
Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy이탈리아에서 COVID-19 대유행의 1차 및 2차 파동 동안 증상, 무증상 및 회복기 감염이 있는 36명의 남성 정액에서 SARS-CoV-2 RNA 배출 평가Article Published on 2022-03-012022-09-11 Journal: Asian journal of andrology [Category] SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assessment Asymptomatic Chain Reaction Clinical practice convalescent coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 pandemic defined detectable detection determine Diagnosis enrolled Evidence evidence of Frame Infection interview Italy male medical history men Mild Nasopharyngeal swab nasopharyngeal swabs nested PCR no evidence of no symptom Open reading frame ORF Patient PCR persistence polymerase chain reaction positive public health real-time reverse transcriptase-polymerase chain reaction real-time RT-PCR receptor recovering from COVID-19 Result reverse transcriptase reverse transcriptase-polymerase chain reaction risk of transmission RT-PCR sampling SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA second wave Semen Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sexual intercourse sexual transmission symptomatic Symptoms was performed [DOI] 10.4103/aja2021103 PMC 바로가기 [Article Type] Article
Breakthrough SARS-CoV-2 infections among BBV-152 (COVAXIN®) and AZD1222 (COVISHIELD TM ) recipients: Report from the eastern state of IndiaBBV-152(COVAXIN®) 및 AZD1222(COVISHIELD TM ) 수혜자 사이의 획기적인 SARS-CoV-2 감염: 인도 동부 주에서 보고Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Antibody titer Antibody titers Antigen AZD1222 be positive breakthrough Breakthrough infection breakthrough infections collected Complete coronavirus 2 coronavirus disease Coronavirus disease-19 COVAXIN® COVID-19 COVISHIELDTM detect dose healthcare facility highlight Home isolation Hospitalization hospitalized patients IgG titer value Immunity India individual interquartile range less median median age MONITOR Nasopharyngeal swab Older age Patient positive Postinfection Quantitative receiving Receptor binding domain recipient recipients report reported required respiratory SARS-CoV-2 SARS-COV-2 infection Seropositivity serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Swab symptomatic vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development Vaccines variant variants virus infection [DOI] 10.1002/jmv.27382 PMC 바로가기 [Article Type] Article
A four-month follow-up study of Cardiac performance in patients hospitalized with COVID-19 in a Tertiary Care Government Medical HospitalConference abstract Published on 2022-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 바이오마커, [키워드] abnormality acute COVID-19 acute phase age alteration Analysis analyzed average Biomarker Cardiac abnormality cardiac disease cardiac function Cardiac performance cardiac troponin cardiovascular risk cardiovascular risk factor change clinical symptom conducted contrary coronavirus disease COVID-19 COVID-19 hospitalization COVID-19 illness COVID-19 infection diabetes diastolic dysfunction Dyspnea echocardiographic Elevation Factor follow-up study hypertension Infection information Injury laboratory-confirmed male manifestation marker material Myocardial infarction myocardial injury myocarditis Necrosis Patient patients hospitalized Pneumonia pulmonary artery pressure questionnaire reported Result sensitivity analysis significant increase statistically significant symptomatic Tertiary the SARS-CoV-2 ventricular with COVID-19 [DOI] 10.1016/j.ijid.2021.12.135 [Article Type] Conference abstract