Conducting Clinical Research During the COVID-19 Pandemic: Investigator and Participant PerspectivesViewpoint Published on 2020-04-062022-10-31 Journal: JMIR Public Health and Surveillance [Category] Coronavirus, SARS, [키워드] change Clinical research clinical trials Community complex Conducting coronavirus disease Course COVID-19 Ethics Factor Guidance helping Infectious disease investigator involved Local National organizations outbreak pandemic participant Perspective provide psychological support public health Regulatory Research researcher responsible risk subject Support while [DOI] 10.2196/18887 PMC 바로가기 [Article Type] Viewpoint
CT imaging changes of corona virus disease 2019(COVID-19): a multi-center study in Southwest ChinaResearch Published on 2020-04-062022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] absorbed analyzed average bilateral lungs change changed changes Characteristics chest CT examination Chest CT image Chest CT images China Chinese hospitals clinical manifestation clinical manifestations close contact collected Complication Computed tomography confirmed case Confirmed COVID-19 infection consolidation coronavirus coronavirus disease cough COVID-19 diagnosing Evolvement feature Fever Follow-up ground glass ground glass opacities Ground glass opacity had more hospitalized patient Infection involved lesion lesions lobe lung Lymph node manifestation MOST multiple lesion patchy Patient Pneumonia progression Result Retrospective study The chest Virus Disease Wuhan Wuhan, China [DOI] 10.1186/s12967-020-02324-w PMC 바로가기 [Article Type] Research
Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies Research Published on 2020-04-012022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] 진단, 치료기술, 치료법, [키워드] 2019 novel coronavirus age alveolar epithelial cells Bacterial biopsy bronchopneumonia change cirrhosis Cluster component condition consolidation contribute COVID-19 death diabetes died Diffuse alveolar damage disease disease onset Disease progression elevated exhibit Extracellular matrix fatality female fibrosis hyaline membrane formation hypertension immunocompromised status infiltration Injury intra-alveolar knowledge leukemia liver lobular lung Lungs Lymphocytes lymphocytopenia male Mild Myocardial Necrosis neutrophilic pathologic pathological pathology Patient patients performed Pneumonia postmortem examination proliferation ranged renal the patient time type II pneumocytes underlying conditions underlying disease underlying diseases White blood cell [DOI] 10.1038/s41379-020-0536-x [Article Type] Research
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagationArticle Published on 2020-03-302022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Analysis Antiviral antiviral strategy biological pathways biological processe Calu-3 Cell cells cellular change characterized circRNA Circular competing endogenous RNA demonstrated epithelial expression expression pattern Factor function group highly pathogenic Host host genes human lung in viral Infection investigated involved KEYWORDS: MERS-CoV knockdown MAPK MERS-CoV MERS-CoV infection metabolic processes Middle East miRNA modulate mRNA noncoding RNA Pathways perturbations predicted proportion Protein provided reaction recent reduced Regulatory required respiratory syndrome coronavirus reveal RNA selected significantly siRNA Specific Structure target mRNA targets unique Variation viral infections [DOI] 10.1080/22221751.2020.1738277 PMC 바로가기 [Article Type] Article
Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19혈소판 대 림프구 비율은 코로나바이러스 질병-19 환자의 예후와 관련이 있습니다Research Article Published on 2020-03-262022-09-25 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, 진단, [키워드] age Analysis analyzed average Blood routine case sery change China collected coronavirus coronavirus disease COVID‐19 Cytokine storm demographic elevated Factor hospital Hospitalization hospitalized patient independent Laboratory results Novel coronavirus Older Patient Platelet platelet value platelet‐to‐lymphocyte ratio Platelets Pneumonia pneumonia cases Prognosis risk factor Severe patient severe patients severity and prognosis significantly Spread the cytokine storm the disease Treatment Wuhan [DOI] 10.1002/jmv.25767 PMC 바로가기 [Article Type] Research Article
Publishing in the time of COVID-19Editorial Published on 2020-03-252022-10-31 Journal: eLife [Category] Coronavirus, MERS, SARS, [키워드] change COVID-19 early-career researchers peer review preprints Scientific community scientific publishing [DOI] 10.7554/eLife.57162 PMC 바로가기 [Article Type] Editorial
Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19)Infectious Disease Published on 2020-03-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acetazolamide Activation acute respiratory distress addition Anti-viral appear approach ARDS asymmetric caused change Clinical data Coagulation condition Contagion coronavirus countermeasure COVID-19 COVID-2019 CT finding Diffuse alveolar damage edema Effect effective elevated expired fatality fibrinogen level ground glass opacities Ground glass opacity ground-glass opacity Hemorrhagic high altitude pulmonary edema hypoxia hypoxic IMPROVE include increase in indication induce inhibitors lung medication minute ventilation Nifedipine Novel coronavirus organ systems oxygen patchy pathophysiologic pathophysiology patients with COVID-19 Perspective phosphodiesterase pro-inflammatory Pulmonary edema rationale reduce Respiratory care Respiratory illness respiratory parameter shown similarity survival syndrome tachypnea Treatment utilization vasoconstriction while Wuhan coronavirus [DOI] 10.7759/cureus.7343 PMC 바로가기 [Article Type] Infectious Disease
Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysisOriginal Article Published on 2020-03-182022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] ACE2 affected Analysis binding energy caused change changes in coronavirus determine Epidemic Epidemics event higher affinity host receptor human ACE2 human ACE2 receptor humans in silico in silico Approach Interaction Ligand magnitude outbreak promote receptor reduction in role SARS-CoV-2 SARS-CoV-2 spike protein sequence significant effect spike Spike protein the disease the receptor-binding domain the S1 subunit the SARS-CoV-2 the spike protein Transmission viral disease Viral protein viral spread was performed zoonotic [DOI] 10.17179/excli2020-1167 PMC 바로가기 [Article Type] Original Article
Transmission dynamics of the COVID‐19 outbreak and effectiveness of government interventions: A data‐driven analysisResearch Article Published on 2020-03-162022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis basic reproductive number change Chinese conducted confirmed case contributed coronavirus coronavirus disease country COVID‐19 COVID‐19 Data fitting data simulation Decline declines drug early treatment effective effective reproductive number Effectiveness effort Evidence Government high infectiousness hospitals identify increase in indicated Intervention Isolation key factor less measure Measures Novel coronavirus outbreak pandemic performed Precision Protective reproductive required SARS‐CoV‐2 SEIR sensitivity analysis Spread the epidemic therapeutic strategy Transmission Treatment [DOI] 10.1002/jmv.25750 PMC 바로가기 [Article Type] Research Article
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) PneumoniaResearch Paper Published on 2020-03-152022-10-28 Journal: Theranostics [Category] COVID-19, MERS, [키워드] 2019 novel coronavirus change China Clinical characteristics Clinical outcome Clinical treatment COVID-19 COVID-19 pneumonia CT scan defined died discharged evaluate Features follow up Follow-up help hospital Hospital stay investigated median MOST novel outcome outcomes Patient Pneumonia progressed progression remained response Risk factors single-center study Symptom Treatment Treatment response [DOI] 10.7150/thno.45016 PMC 바로가기 [Article Type] Research Paper