Genetic Analysis of Avian Coronavirus Infectious Bronchitis Virus in Yellow Chickens in Southern China over the Past Decade: Revealing the Changes of Genetic Diversity, Dominant Genotypes, and Selection PressureArticle Published on 2019-09-262022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid Analysis ancestor Bayesian change changed chicken China circulating decrease Diversity dominant Entropy Evolutionary rate Genetic genetic diversity Genotype genotypes high mutation rate IBV Infectious Bronchitis Virus insertion isolate isolates molecular molecular evolutionary rate N gene Phylogenetic tree Positive selection pressure Proteins Purifying recombinants Recombination Selection selection pressure strain threat urgency Vaccine Variation virus yellow [DOI] 10.3390/v11100898 PMC 바로가기 [Article Type] Article
Changes in cecal microbiota community of suckling piglets infected with porcine epidemic diarrhea virusResearch Article Published on 2019-07-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 16S rRNA gene Bacteria Bacteroidete catastrophic caused change Community diarrhea Diseases epidemic diarrhea functional annotation Fusobacterium gastrointestinal disease group groups healthy Infection intestinal investigated microbial microbiota morbidity Mortality mucosa occurred pathogen pathogenic bacteria PEDV Prevent proportion Proteobacteria Research Sequencing the healthy virus virus infection was increased was performed [DOI] 10.1371/journal.pone.0219868 PMC 바로가기 [Article Type] Research Article
Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cellsResearch Article Published on 2019-07-082022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Actin activate activated Analysis Antigen binding block Cell cellular change DCs dendritic cell dendritic cells disease-causing down-regulated ENhance explain functional Gene Expression Gene ontology Host IBV immune immune function inactivated indicated induce Infection Infectious Bronchitis Virus innate response Interaction leukocyte lncRNA long non-coding RNA Lymphocytes MAPK maturation mechanism Microarray microRNA miRNA miRNAs mRNA mRNAs neutralising non-coding RNA oxidative phosphorylation pathogenic mechanism pathway Pathway analysis performed presenting Protein provide recent regulate Research respond responsible Result significantly suggested supplementary material T cells target gene transcription factor transendothelial migration up-regulated viruses [DOI] 10.1186/s12864-019-5940-6 PMC 바로가기 [Article Type] Research Article
Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antiviralsC형 간염 바이러스는 직접 작용하는 항바이러스제에 의한 감염 치료 후 후성 유전적 특징을 남깁니다.Research Article Published on 2019-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Alter alteration Anti-HCV Antiviral approach Biomarker Cell cells change changes in characterized Chemotherapy ChIP-seq chromatin chromatin immunoprecipitation chronic hepatitis develop direct-acting antiviral disease drug Effect EGFR EGFR Inhibitor enzyme Epidemiological study Epigenetic Erlotinib Europe expected explain expression followed by gene signature Genome HCC HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma histone Hit and run host gene expression identify in vitro induce infected case infected patient Infection inhibit inhibitor interferon life cycle liver Liver Biopsy marker mechanism Modification molecular mechanism Mortality Multiple Multiple epidemiological studies Next-generation sequencing observation offer oncogenic outcome Pathogenesis pathogenic Pathways Patient persist poor prognosis post-translational modification predominant Prevalence proceed replaced repressed risk risk factor RNA signaling pathway specific inhibitor specific inhibitors sustained the cells therapeutic target therapy Treatment Tumor unmet need Viral protein Viral proteins virological response virus while [DOI] 10.1371/journal.pgen.1008181 PMC 바로가기 [Article Type] Research Article
An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndromeADAMTS3 missense 변종은 Norwich Terrier 상기도 증후군과 관련이 있습니다.Research Article Published on 2019-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADAMTS3 addition affected airway airway obstruction airways Analysis approach association assumed breed Bulldog candidate gene canine caused change characteristic chromosome chromosome 13 contribute Critical determinant determinants disease Disruption dissociate English ENhance error examined ExoN facial feature flat French French bulldog Frequency Genetic genetic association genetic screens genetics Genome genome-wide association Health health screening heterogeneous highlight identify independent independent of Intervention Laryngoscopy loss of function Missense mutation missense variant motif oedema offer overlap pathology performed predisposing factor predisposition presenting prevalent Previous studies previous study prognostics resolved respiratory Respiratory disease respiratory diseases respiratory obstruction risk allele scored screened severity shown skull surgical surgical interventions Symptom syndrome Terrier treat upper upper airway variant variants was used [DOI] 10.1371/journal.pgen.1008102 PMC 바로가기 [Article Type] Research Article
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling PigletsImmunology Published on 2019-04-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] acute diarrhea Affect affected antibody antibody secreting cell ASC B cells cause change circulating Control correlated Course Critical Cytokines determine during pregnancy epidemic diarrhea example gestation gut-mammary-secretory IgA axis IgA IgG immature immune system immune parameter immune protection immune response Immunity Impact implication Infection influence inoculated intestinal lactogenic Lactogenic immunity lymphocyte Maternal medium mucosal naïve Neonatal Neonate Neutralizing PEDV positively correlated Pregnancy pregnant protection required response resulting serum significantly significantly higher Stage stimulate stimulated subsequent Suckling survival survival rate swine three group Vaccines viral infections virulence virus [DOI] 10.3389/fimmu.2019.00727 PMC 바로가기 [Article Type] Immunology
What is mutation? A chapter in the series: How microbes “jeopardize” the modern synthesis돌연변이 란 무엇입니까? 시리즈의 한 장: 미생물이 현대 합성을 "위태롭게"하는 방법Review Published on 2019-04-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated assumed Bacteria cancer development chance change Clusters Evolution function Genes genomes genomic Infectious disease life Local mechanism microbe molecular mechanism molecular mechanisms Mutagenesis Mutation occur Protein regulated response Stress stress responses translated tree tree of life up-regulated [DOI] 10.1371/journal.pgen.1007995 PMC 바로가기 [Article Type] Review
Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seqResearch Article Published on 2018-08-072022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated addition Allograft Alter Analysis APN Apoptosis Autoimmune disorders B cell Cell change characterization collected cytotoxicity DC-SIGN death deregulated disease Diseases dissemination down-regulated enrichment analysis Fever fold healthy Host immune complex indicated Interaction involved KEGG L-SIGN Laboratory less lymphopenia Macrophage mature macrophages MHC I mRNA mRNA expression NK cell other coronavirus pathogen pathway peritoneal macrophage populations receptor rejection RNA expression RNA-Seq serotype Signaling significantly Th1 Th2 transcript upregulated virus were infected [DOI] 10.1186/s13567-018-0578-y PMC 바로가기 [Article Type] Research Article
Machine learning identifies signatures of host adaptation in the bacterial pathogen Salmonella enterica기계 학습은 박테리아 병원체 Salmonella enterica에서 숙주 적응의 신호를 식별합니다Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 살모넬라증, [키워드] analyses Analysis approach architecture Atypical bacterial pathogen Bacterial pathogens bacterial specy build captures change changes in Classifier complex interaction continuum convergence data sets Degradation detect disease disease phenotype Disease surveillance dissect enrichment Epidemic epidemiological purposes functional Gastrointestinal infection Genes genome sequence genomic data high mortality HIV host adaptation host range identify Immunocompromised implementation Inclusion Infection input invasive invasive disease lead Lineage lineages machine member metabolic pathway metabolic pathways Mortality Mutation New outcome pathogen pathogenic Pathogens phenotype Population predict Predictive protein coding gene protein coding genes public health random Random forest rare variant Rare variants required Salmonella Salmonella Enteritidis scaled sequence Sequencing shift species strain Strains sub-Saharan Africa Surveillance [DOI] 10.1371/journal.pgen.1007333 PMC 바로가기 [Article Type] Research Article