Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article
Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli생물막 미세 환경은 대장균에 강력한 적합성을 부여하는 광범위한 적응 아미노산 발효 경로를 유도합니다Research Article Published on 2017-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1-propanol adaptive aerobic Amino acid amino-acid Bacterial bacterial communities balance biofilm cellular change characterized Clostridia competition complex condition conditions contribute Degradation E . coli Enterobacteriaceae Escherichia coli exploration Genetic modifications growth hypoxic hypoxic condition hypoxic conditions identify induce liquid cultures maintain metabolic pathway metabolic pathways metabolism microenvironment pathway physiological responses produced propanol provide reducing threonine Trigger widespread [DOI] 10.1371/journal.pgen.1006800 PMC 바로가기 [Article Type] Research Article
The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cellsResearch Article Published on 2017-03-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions Zoonotic coronavirus [DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크Research Article Published on 2017-02-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] activity Algorithm Analysis Antibiotic resistance applied approach arising Bacteria Bacterial bases Beta-lactam beta-lactam antibiotics candidate cellular change chromosome coding sequence complement contribute Critical data set data sets dataset dihydrofolate Diversity DNA driver ENhance epistasis epistatic interaction epistatic interactions Evolution experimental work functions Genes Genetic variation Genome Genome-wide association studies Genome-wide association study genomic Genomic analysis genomic data highlight human pathogen hypothese hypotheses identify Interaction interactions lack Linkage disequilibrium loci locus non-susceptibility Organisms over parameter Pathogens pbp1a phenotype pneumococcus polymorphism Polymorphisms Protein pseudouridine recent representing reveal RNA sequence sequences significantly statistical statistical model statistically Streptococcus Streptococcus pneumoniae Streptococcus pyogene Streptococcus pyogenes structural biology synthases Systems biology target targets the strongest trimethoprim underlie virulence [DOI] 10.1371/journal.pgen.1006508 PMC 바로가기 [Article Type] Research Article
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated StrainArticle Published on 2016-11-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Attenuated carried change Comparative diarrhea epidemic diarrhea eukaryotic expressed groups Heat shock heterogeneous immune system Infection inoculated Interaction interferon-stimulated gene involved ISGs iTRAQ Jejunum labeling Laboratory mechanism Mortality nuclear organ Pathogenesis pathogenicity PEDV Porcine epidemic diarrhea virus predominant produced Protein proteomic quantitation quantitative proteome analysis response responses responsible ribonucleoprotein Signal transduction strain Strains Stress tissue up-regulated virulent virus [DOI] 10.3390/v8120323 PMC 바로가기 [Article Type] Article
Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo고유한 프리온 도메인 서열은 생체 내 샤페론 결합 또는 처리를 촉진하여 효율적인 아밀로이드 증식을 보장합니다Research Article Published on 2016-11-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting aggregate Alter Amino acid amyloid assembly binding change chaperone chaperones complementary composed conformation conformational conformational flexibility contribute creating efficient element elements Ensure functional in vitro in vivo inheritance Interaction maintain mechanism molecular observation occur open persistence physical physical properties predict prion processing promote Promoting Propagation Protein Protein misfolding Proteins proximal PSI question Regulation required resulting sequence Spectrum stability Transmission yeast [DOI] 10.1371/journal.pgen.1006417 PMC 바로가기 [Article Type] Research Article
Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word countArticle Published on 2016-11-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] activity addition Analysis change changes in condition diagnostic directional Ebola Ebolavirus Effectiveness Epidemics Factors Genome growth Host hosts human cell influenza A influenza A virus Influenza virus Invasion Long MERS coronavirus Middle East mutate oligonucleotide outbreak primer RNA virus RNA viruses RT-PCR sequence siRNAs subtype Subtypes therapeutic thought virus West zoonotic [DOI] 10.1038/srep36197 PMC 바로가기 [Article Type] Article
A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues다중 상태 토글 스위치는 곰팡이 세포의 운명을 정의하고 시너지 유전 신호에 의해 조절됩니다Research Article Published on 2016-10-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompany Analysis antagonistic can be used Candida tropicalis Cell cell differentiation cell fate cell type cell types cellular change chromatin Combination determined by ectopic ectopic expression Epigenetic event exhibit expression Fate Formation fungal fungi Gene Expression Gene expression profiles Genetic genetic analysis genetic regulation growth rates higher eukaryotes hybrid increase induce instances lack less master regulator multicellular organism multicellular organisms occurred opposite pathogen phenotypic Regulation stability stable cell stem cell switch switching synergistic to define transcription factor transcription factors transcriptional transcriptionally underlie unique Wor1 yeast [DOI] 10.1371/journal.pgen.1006353 PMC 바로가기 [Article Type] Research Article
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article