Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin DReview Published on 2020-09-212022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Activation cell death cellular homeostasis consequence contagiousness contribute COVID-19 cytokine production Cytokines death decrease deficiency Effect Evidence Health IMPROVE individual Inflammation inflammatory process inflammatory state involved knowledge mitochondrial mitochondrial dynamics oxidative stress Potential pro-inflammatory state Prognosis provoke recent reduce Regulation renin-angiotensin-aldosterone system risk risk factor role ROS SARS-CoV-2 SARS-COV-2 infection syndrome virus Vitamin D vitamin D level [DOI] 10.3390/antiox9090897 PMC 바로가기 [Article Type] Review
The role of mesenchymal stromal cells in immune modulation of COVID-19: focus on cytokine stormReview Published on 2020-09-182022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, [키워드] activities acute respiratory distress acute respiratory illness adaptive administration ARDS cause contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 patients Cytokine storm death homogenous Immune cell immune modulation Immune regulatory immune response immune systems immunoregulatory property Immunosuppression IMPROVE Inflammation Interaction Lung function mesenchymal stem cell Mesenchymal stromal cells MSC MSCs outbreak pandemic Pathogenesis Pathogens pathology patients patients with COVID-19 populations produced pulmonary fibrosis reduce research finding responsible SARS-CoV-2 stem cell stromal cell Symptoms syndrome the cytokine storm these cell tissue tissues virus [DOI] 10.1186/s13287-020-01849-7 PMC 바로가기 [Article Type] Review
Clinical Burden and Unmet Need in Recurrent Pericarditis: A Systematic Literature ReviewReview Article Published on 2020-09-182024-09-04 Journal: Cardiology in review [Category] 대상포진, [키워드] Acute pericarditis Inflammation pericardiectomy recurrent pericarditis [DOI] 10.1097/CRD.0000000000000356 PMC 바로가기 [Article Type] Review Article
Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current StatusImmunology Published on 2020-09-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE-2 ACE2 acute respiratory syndrome ADE aggravate angiotensin Antibody-dependent enhancement Antiviral binding clinical manifestation combating Complication coronavirus strains country COVID-19 current death disease economic loss effective Efficacy exhibit feature genomic Health high mortality human cell immunopathology imperative include infected cases infection with SARS-CoV-2 infections Inflammation inhibitor interfere Lung injury mitigate molecular target molecule more difficult natural antiviral natural Nrf-2 modulators NSMIs oxidative stress patients pharmacological agent Pneumonia positive Protein reported respiratory S-protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 strain SARS-CoV2 small molecule inhibitor spike status Strategy targeting the SARS-CoV-2 Vaccine viral entry viral propagation [DOI] 10.3389/fimmu.2020.552925 PMC 바로가기 [Article Type] Immunology
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19Physiology Published on 2020-09-182022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 ACE2 expression adipose aggravate angiotensin angiotensin-converting enzyme 2 cardiovascular disease caused cells changes in chronic disease clearance correlated COVID-19 COVID-19 pandemic dataset described diabete dysregulated expression expression of gene Host host cell in silico in vitro in vitro result increased risk infected with SARS-CoV-2 Inflammation Injury involved knowledge lipid metabolism lung lung epithelial cell Lungs mechanism Mortality novel coronavirus SARS-CoV-2 obese obese patient obesity pathway Patient Protein pulmonary inflammation receptor regulated Regulation risk factor SARS-CoV-2 severe complication shown Signaling significant increase smoking subject subjects suppression tissue TMPRSS2 transcriptomic data upregulation validation viral entry viral replication virus [DOI] 10.3389/fphys.2020.555039 PMC 바로가기 [Article Type] Physiology
Familial Mediterranean Fever and COVID-19: Friends or Foes?Immunology Published on 2020-09-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition analyzed bat C-reactive protein characterized clinical symptom Colchicine conserved COVID-19 COVID-19 patient COVID-19 patients Cytokine storm effective Familial Fever FMF disease Friend hallmark highly pathogenic Host Human humans IL-1 infections Inflammation inhibitor Innate immunity Laboratory Leukocytosis mammals Mutation off-label overlap Pain Patient Protein pyrin residue SARS-CoV-2 sequence severe disease the cytokine storm Treatment variant wildtype [DOI] 10.3389/fimmu.2020.574593 PMC 바로가기 [Article Type] Immunology
Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19Article Published on 2020-09-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation acute kidney failure Acute kidney injury acute respiratory syndrome adaptive Biliary biliary lesion CD8 T cells Cell cellular Characteristics characterized cholestasis coronavirus coronavirus disease Course COVID-19 disease Follow-up GGT granulocyte hepatopathy histological IL-6 immature immune response Immunity infiltration Inflammation Inpatient laboratory feature lesion Liver disease marker Mild moderate organ pathophysiology Patient Profiling progressed proinflammatory SARS-CoV-2 serum T cells the disease university [DOI] 10.3390/jcm9093000 PMC 바로가기 [Article Type] Article
Granulomatous inflammation in pulmonary pathology of 2019 novel coronavirus pneumonia: case report with a literature reviewCase Report Published on 2020-09-162022-10-28 Journal: Surgical and Experimental Pathology [Category] COVID-19, [키워드] 2019 novel coronavirus Administered alveolar epithelial cell biopsy bone Breast cancer Case report changes Computed tomography Coronavirus disease 2019 COVID-19 COVID-19 case described desquamation Diagnosis dry cough edema evaluated fatigue Fever fibrosis flow cytometry granulomatous inflammation heterogeneous hospital IMPROVE infecting Infection Inflammation interstitial Laboratory test leukemia literature review lung lung biopsy Lung CT images Lung histopathology images Lungs malignancy manuscript mild inflammatory infiltration organized pandemic Physical examination Pneumonia polymerase chain primary care progression Pulmonary pathology rale reported swab sample Test Throat tomography Tuberculosis upper respiratory tract vascular congestion was performed Wuhan, China [DOI] 10.1186/s42047-020-00071-2 PMC 바로가기 [Article Type] Case Report
In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression AnalysisPharmacology Published on 2020-09-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ADORA2A ADRB2 alleviation Analysis Anti-inflammatory antioxidant approach Astragaloside IV Bioinformatic Bioinformatics analysis caused chemokine contribute COVID-19 COVID-19 patients cytokine cytokine storms dataset DEGs differentially expressed gene down-regulated genes drug candidate GBP1 Gene Expression Omnibus Genes GEO GO term GSE147507 hyper-inflammation hyperinflammation IL1B IL6 Inflammation KEGG KEGG pathway Kyoto MLNR MMP13 network network pharmacological network pharmacology NFKBIA NLRP3 Ontology overlap overlapping pathway pathway enrichment performed pharmacological mechanism Pharmacology Potential prediction PTAFR Result SARS-CoV-2 screened System target TNF Treatment TRIM21 up-regulated [DOI] 10.3389/fphar.2020.556984 PMC 바로가기 [Article Type] Pharmacology
Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic StrategiesReview Published on 2020-09-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] accompanied acute respiratory syndrome adverse outcome angiotensin-converting enzyme 2 arrhythmia atherosclerotic plaques Blood clots cardiac event cardiac muscle cardiovascular cardiovascular complications cardiovascular diseases Clinical efficacy clinical trials Complication coronavirus disease COVID-19 COVID-19 patient COVID-19 patients death dysfunction elevated endothelial Evidence heart failure high risk highlight impairment include infected patients Infectious disease Inflammation Invasion mechanism multiple organ dysfunction Myocardial Myocardial infarction myocardial injury myocarditis outbreak oxygen supply pathophysiological mechanism Potential Prognosis reveal risk SARS-CoV-2 virus shown Strategy Stress Therapeutic approach therapeutic options thrombosis Treatment strategies with COVID-19 worldwide pandemic [DOI] 10.3390/ijms21186790 PMC 바로가기 [Article Type] Review