Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assayMethodology Published on 2020-09-102022-10-29 Journal: Journal of Nanobiotechnology [Category] Coronavirus, SARS, [키워드] accelerate analyzed antibody assays Biomarker C-reactive protein C-reactive protein (CRP caused clinically complex Conjugation chemistry consequence Conventional COVID-19 CRP Cytokine storm Diagnosis diagnostics Duplex lateral flow assay event events FIVE Gold nanoparticle handling IL-6 Image processing ImageJ immunoassay include Infection Inflammation Inflammatory information intensities interleukin-6 lateral flow limits medical need Multiplexing Nanoparticles optical pathophysiology POC point-of-care point-of-care diagnostics powerful tool provide quantification Quantitative quantum dots R-package Sandwich immunoassay Sensitivity and specificity Sepsis Shiny app target protein targets test line Treatment was used were used [DOI] 10.1186/s12951-020-00688-1 PMC 바로가기 [Article Type] Methodology
Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospectsReview Published on 2020-09-092023-07-02 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, [키워드] ACE, angiotensin-converting enzyme ACE2, angiotensin-converting enzyme 2 ADAM10, Metalloproteinase domain-containing protein 10 ADAM17, Metalloproteinase domain-containing protein 17 ADCC, antibody-dependent cellular cytotoxicity ADT, Androgen deprivation therapy androgen Angiotensin-converting enzyme-2 (ACE2) CCL2, C-C motif ligand 2 CD40L, CXCR3, C-X-C motif receptor 3 COVID-19 COVID-19, Coronavirus disease 2019 CXCL-1, C-X-C motif ligand 1 CXCL8, C-X-C motif chemokine ligand 8 Cytokine storm E1, Estron E2, Estradiol E3, Estriol ePDI, Extra-endoplasmic reticulum PDI ERα, Estrogen receptor-alpha ERβ, Estrogen receptor-beta ERs, Estrogen receptors Estrogen FcγRIIIA, Low affinity immunoglobulin gamma Fc region receptor III-A H1N1, Influenza A virus subtype H1N1 H3N2, Influenza A virus subtype H3N2 HCoV-NL63, human coronavirus NL63 ICU, Intensive care unit IFN-γ, Interferon-gamma IL-6, interleukin 6 Inflammation JSTOR, Journal storage mRNA, messenger RNA NF-kB, Nuclear factor kappa B NKCs, Natural killer cells PDI, Protein disulfide isomerase RAS, Renin-angiotensin system RNA, Ribonucleic acid ROS, reactive oxygen species SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus TLR7, Toll-like receptor 7 TLR8, Toll-like receptor 8 TMPRSS2, transmembrane protein serine 2 WHO, World Health Organization Xp22, Chromosome X band p22 [DOI] 10.1016/j.biopha.2020.110748 PMC 바로가기 [Article Type] Review
Can Nuclear Imaging of Activated Macrophages with Folic Acid-Based Radiotracers Serve as a Prognostic Means to Identify COVID-19 Patients at Risk?Opinion Published on 2020-09-092022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activated activated macrophage acute respiratory distress applied ARDS bind Can Cancer clinical trials complications Coronavirus infections COVID-19 COVID-19 patient Cytokine storm Cytokines develop disease expressed Exuberant folate receptor-beta (FRβ) folate-based 18F-PET tracer host responses IL-1β IL-6 imaging imaging biomarker immune Inflammation inflammatory conditions Interstitial lung disease involved life-threatening Lung diseases Macrophage macrophages modulating multicenter nuclear outcome patients patients with COVID-19 positron emission tomography (PET) radiotracer risk severe disease progression Support syndrome tested therapy TNFα Trial [DOI] 10.3390/ph13090238 PMC 바로가기 [Article Type] Opinion
A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial미분화 결합 조직 질환이 있는 여성의 반복적인 임신 상실을 치료하기 위한 하이드록시클로로퀸 및 저용량 프레드니손의 3군, 다기관, 공개 라벨 무작위 대조 시험: LIFE(LIFE) 시험을 위한 면역억제 요법에 대한 프로토콜Study Protocol Published on 2020-09-092022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] abortion Activation addition Anticoagulant anticoagulation Arm assigned connective tissue connective tissue disease Controlled trial defined disease Efficacy eligible patient evaluate Evidence HCQ Hydroxychloroquine immune Immunosuppressant include induce Inflammation live births low-dose morbidities multicenter Open-label open-label randomized controlled trial outcome Patient patients placental Prednisone Pregnancy Prevent Primary outcome Prognosis progression protocol Randomized controlled trial Randomly Recurrent pregnancy loss Recurrent spontaneous abortion regimen secondary Secondary outcomes spontaneous abortion treat Trial Trial registration Undifferentiated Undifferentiated connective tissue disease Vascular damage women [DOI] 10.1186/s13063-020-04716-1 PMC 바로가기 [Article Type] Study Protocol
Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-09-092022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 Ability Ability to walk Activation adhere administer ambulatory patient anatomical Anticoagulant treatment anticoagulation antiplatelet Atrial fibrillation baseline bleeding Blinding block size body temperature calculated Cardiovascular events characterized Chemotherapy clearance clinical benefit clinically Coagulation Coagulopathy Comorbidity Comparator group conducted contraindication control group coronary syndrome coronavirus cough COVID-19 creatinine criteria Critical current death defined diagnosed diagnosed with COVID-19 Diagnosis Disseminated intravascular coagulation dissemination dose Efficacy elderly element eligibility criteria eligible enoxaparin enrolment event event rate experimental group Face mask FIVE fixed heart failure help heparin-induced thrombocytopenia Hospitalization hospitals hygiene hypersensitivity impairment IMPROVE In-hospital Inflammation information injection inoperable Intervention intervention group invasive Ischemia Laboratory lack Last Liver disease lower limb major bleeding malignancy multicentre Myocardial number objective Older Open-label outcome parameter participant Participation Patient performed Platelet Positive test Presence prevention protocol provided Radiotherapy randomised randomised controlled trial randomization randomization ratio Randomized Randomized controlled trial receive reduce renal respiratory symptom resulting risk factor Sample size SARS-CoV2 secondary Seven Shortness of breath sore throat Spinal cord injury status Stratified randomization stroke Study protocol Support surgical survival symptomatic the patient therapy Thromboprophylaxis thrombosis total sample size Transport trauma Travel treated Treatment undergo university university hospital Venous Thromboembolism vessel viral disease VTE website [DOI] 10.1186/s13063-020-04678-4 PMC 바로가기 [Article Type] Letter
Chest imaging findings in COVID-19 patients: a case series from NigeriaCase Series Published on 2020-09-092022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] age case sery cause change Chest chest imaging COVID-19 COVID-19 cases description Diagnosis differential diagnose disease Follow-up global pandemic imaging Infectious disease Inflammation initial nasopharyngeal swabs Nigeria observation polymerase chain positive reported Respiratory system sub-Saharan Africa tested transcriptase [DOI] 10.11604/pamj.2020.37.39.25006 PMC 바로가기 [Article Type] Case Series
Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic ComplicationsArticle Published on 2020-09-082022-10-30 Journal: Molecular neurobiology [Category] COVID-19, MERS, SARS, [키워드] activated addition Affect affecting Aminoacridine anti-inflammatory agents Anti-inflammatory drugs antimalarial Antimalarials Aortic body arachidonic acid blood vessels Brain endothelial cells carotid body Cell culture Central nervous system Chloroquine clinical trial CNS combating Complication coronavirus coronavirus disease Coronavirus replication COVID COVID-19 COX cPLA2 cross cytokine Cytokine storm cytosolic Cytosolic phospholipase A2 Dementia disorder DMT1 drug Effect Eicosanoids ENhance expression free radical Free radical damage free radical formation generate Glossopharyngeal nerve hippocampus Hydroxychloroquine Hypoxemia impair induce Inflammation Inflammatory response inhibit inhibiting inhibition inhibitor iron accumulation Iron transport isoform isoforms lung lysosomal enzymes lysosome Lysosomes mice Microcirculation microglia Microvessels Neuroinflammation Neurovascular Nucleus of the tractus solitarius organ oxidative damage oxidative stress PLA2G2D pro-inflammatory produced quinacrine reducing Respiratory centre resulting SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 virus Secretory phospholipase A2 Seizures severe cases shown silent sPLA2 IID statins stroke the SARS-CoV-2 virus tissue TNF-α Treatment unique vagus nerve Vascular vascular dementia viral replication [DOI] 10.1007/s12035-020-02093-z PMC 바로가기 [Article Type] Article
Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor BlockersArticle Published on 2020-09-082022-10-30 Journal: Journal of racial and ethnic health disparities [Category] COVID-19, MERS, [키워드] ACE activities acute respiratory distress African allele allele frequency Americans Analysis ANG-II angiotensin Angiotensin-converting enzyme Asian binding black blocker cohorts Comorbidity correlated COVID-19 COVID-19 incidence COVID-19 infection COVID-19 infections Deletion diabete Diabetic Ethnic European European population explain fibrosis Frequency high risk hypertension I/D I/D polymorphism Impact IMPROVE increase in Infection Inflammation insertion/deletion morbidity Mortality nephropathy obesity objective organ damage outcomes Pathologies pathway polymorphism Prevalence rationale Regression representing Result risk factor severity of COVID-19 sustained therapeutic utility USA white with COVID-19 [DOI] 10.1007/s40615-020-00853-0 PMC 바로가기 [Article Type] Article
Venous thrombosis epidemiology, pathophysiology, and anticoagulant therapies and trials in severe acute respiratory syndrome coronavirus 2 infectionReview Published on 2020-09-082023-06-16 Journal: Journal of vascular surgery. Venous and lymphatic [Category] MERS, [키워드] Coagulopathy Inflammation SARS-CoV-2 thrombosis Venous Thromboembolism virus [DOI] 10.1016/j.jvsv.2020.08.030 PMC 바로가기 [Article Type] Review
IBD Patients Could Be Silent Carriers for Novel Coronavirus and Less Prone to its Severe Adverse Events: True or False?Short Communication Published on 2020-09-082022-10-31 Journal: Cell Journal (Yakhteh) [Category] COVID-19, [키워드] Adverse anti-inflammatory drug Anti-TNF-α anti-TNF-α bowel carrier Chronic disorder Complication coronavirus Corticosteroids COVID-19 Crohn’s disease disease gastrointestinal tract healthy higher risk IBD Immunosuppressant induce Infectious disease Inflammation Mild moderate novel pandemic Patient prone receive reduce silent Treatment ulcerative colitis virus [DOI] 10.22074/cellj.2020.7603 PMC 바로가기 [Article Type] Short Communication