The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory InfectionsReview Published on 2020-09-082022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Eleutherococcus Schisandra Withania adaptive Adaptogen adaptogens Andrographis anti-inflammatory activity Antiviral effect cells clinical study Combination docking driving effective Eleutherococcus senticosus Evidence glycyrrhiza immune system Immunity Inflammation Inflammatory inhibiting melatonin modulating organism oxidative Panax progression Prophylaxis Quality of life Replication respiratory respiratory infections Rhodiola role Schisandra chinensis Stage Treatment viral infection [DOI] 10.3390/ph13090236 PMC 바로가기 [Article Type] Review
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome530 Published on 2020-09-082022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] accompanied Activation acute respiratory distress ARDS Bacteria Bacterial Bacterial infection Bacterial sepsis blockade Burn causes chimeric antigen receptor Clinical efficacy clinical manifestation coagulation cascade COVID-19 COVID-19 patient Critical CRS cytokine cytokine production Cytokine release syndrome diagnosed dysfunction elevated endothelial Endothelial cell Endothelial dysfunction endotheliopathy exhibited highlight Human monoclonal antibody Hyperinflammatory hyperinflammatory responses IL-10 IL-6 IL-6 signaling IL-8 Immunotherapy in vitro data indicate induce infections Inflammation involved life-threatening MCP-1 molecular mechanism monocyte chemotactic protein-1 Pathogenesis Patient Proinflammatory cytokine promoted robust Sepsis severe COVID-19 patient severe COVID-19 patients Signaling Significance syndrome systemic inflammatory response T cell therapy Tocilizumab trans-signaling Treatment vascular endothelial cell [DOI] 10.1073/pnas.2010229117 PMC 바로가기 [Article Type] 530
A Preventive Role of Exercise Across the Coronavirus 2 (SARS-CoV-2) PandemicPhysiology Published on 2020-09-082022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] activity addition adipose Adults aerobic assist benefit Combination Comorbidity coronavirus 2 Coronavirus 2019 COVID-19 decrease Effect Effects Evidence exercise Frequency General population Health healthy higher risk homeostasis improvement include increase individual Infection infection rates Inflammation initial intensity management measure moderate Mortality obesity overweight pandemic Pathologies performed populations reduce Resistance training risk of infection role SARS-CoV-2 Support suppress tissue Volume weight loss with COVID-19 [DOI] 10.3389/fphys.2020.572718 PMC 바로가기 [Article Type] Physiology
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age바이러스 부하, 성별 및 연령에 따른 SARS-CoV-2에 대한 생체 내 항바이러스 숙주 전사 반응Research Article Published on 2020-09-082022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] ACE2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age age and sex Antiviral antiviral response antiviral responses CD8A cells chemokine chemokines chemokines CXCL9 clinical manifestation clinical manifestations contribute coronavirus Course Culture cultures CXCL9 CXCR3 Cytotoxic T cell Cytotoxic T cells days post infection deficiencies deficiency demonstrated dependent on disease severity elapsed elevated examined expression Factor females Gene Expression Genes genomic granzyme B HAE Host host response host responses Host transcriptional response human airway epithelial humoral immune responses IFIT1 immune responses in vivo increase in individual induce Infection Inflammation inhibitor inhibitors interferon interferon signaling interferon-stimulated gene interferon-stimulated genes male mechanism nasopharyngeal natural killer negative controls neutrophil NF-κB nuclear OAS1 Patient PCR-confirmed populations profile Protein Proteins receptor reduced reduction in relative replicated respiratory reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex shotgun shown Signaling specimen Swab T cells T helper Th1 transcript Transcription transcripts up-regulation Viral Viral load wound healing [DOI] 10.1371/journal.pbio.3000849 PMC 바로가기 [Article Type] Research Article
Plasma exchange in critically ill COVID-19 patients improved inflammation, microcirculatory clot formation, and hypotension, thereby improving clinical outcomes: fact or fiction?Letter Published on 2020-09-072022-11-01 Journal: Critical Care [Category] Coronavirus, SARS, [키워드] COVID-19 patient Critically ill Inflammation plasma exchange [DOI] 10.1186/s13054-020-03262-1 PMC 바로가기 [Article Type] Letter
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19Research article Published on 2020-09-062022-10-05 Journal: Cell [Category] SARS, 유전자 메커니즘, [키워드] acute COVID-19 acute respiratory syndrome Analysis Asymptomatic autoantibodies autoantibody autoimmune etiology Biomarker blood immune cells children coronavirus COVID-19 Cytokines elevated enrolled feature Fever healthy children hyperinflammation in children IL-17A infected with SARS-CoV-2 Infection Inflammation Inflammatory Inflammatory response involved Kawasaki disease marker Mild MIS-C multisystem inflammatory syndrome in children organ dysfunction overlapping Pathogenesis presenting SARS-CoV-2 syndrome systems immunology T cell the cytokine storm Vasculitis with COVID-19 [DOI] 10.1016/j.cell.2020.09.016 [Article Type] Research article
Acute kidney injury in patients with SARS-CoV-2 infectionResearch Published on 2020-09-032022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI Activation Acute kidney injury AKI AKI patients association complement complement system proteins confounders COVID-19 COVID-19 patient creatinine criteria defined direct viral infection ferritin ferritin level Final fraction ICU IL-6 Infection Inflammation Inflammatory marker intensive care units interleukin-6 involved KDIGO Kidney injury Laboratory log mechanism Mortality Multiple occurred outcome Patient patients patients with AKI patients with SARS-CoV-2 Prevalence prognostic reported Result risk factor SARS-COV-2 infection severe SARS-CoV-2 severity SOFA score [DOI] 10.1186/s13613-020-00734-z PMC 바로가기 [Article Type] Research
Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19Invited Review Published on 2020-09-032022-10-31 Journal: European Journal of Applied Physiology [Category] COVID-19, MERS, SARS, [키워드] adipose adverse effect association biological processe complex interplay contribute COVID-19 Critical Cytokines disease Diseases Effect effective equipment expression general health status Health status healthy lifestyle immune system Impact infections Inflammation inflammation markers involved mechanism Metabolic disorders moderate modulated modulation molecular molecular mechanism Multiorgan obesity organ pandemic pathophysiology physical activity positive provided reduction in Regulation Result SARS-CoV2 SARS-CoV2 infection Skeletal muscle susceptibility tissue type 2 diabete viral infection viral infections was performed with COVID-19 [DOI] 10.1007/s00421-020-04484-5 PMC 바로가기 [Article Type] Invited Review
Icosapent Ethyl – A Successful Treatment for Symptomatic COVID-19 InfectionAnesthesiology Published on 2020-09-022022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Anti-inflammatory ARDS (Acute Respiratory Distress Syndrome) Care caused COVID-19 COVID-19 patient Cytokine release syndrome (CRS) death elderly patients ethyl General population hyper-inflammation hypertriglyceridemia Icosapent icosapent ethyl ICU indicated Inflammation intensive care Mortality mortality rate much higher omega-3 omega-3 fatty acid pandemic poor prognosis reduce severe COVID-19 disease shown significantly supportive care symptomatic the SARS-CoV-2 virus therapy Treatment [DOI] 10.7759/cureus.10211 PMC 바로가기 [Article Type] Anesthesiology
Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral M pro Protease Target Host Selenoproteins and Glutathione Synthesis?Nutrition Published on 2020-09-022022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activate Algorithm antioxidant catalytically active cleavage site Clinical outcome component contribute coronavirus correlation COVID-19 cysteine protease Cytokine storm cytosolic deficiency DNA Effect exacerbated expected Factor glutathione Glutathione peroxidase glutathione peroxidase 1 GPx GPX1 inactive Inflammation inhibit knockdown M pro mechanism mutant NF-κB NF-κB activation oxidative stress precursors pro-inflammatory cytokines protease proteolytic rate-limiting enzyme reactive oxygen specy resulting ribonucleotide RNA synthesis SARS-CoV M SARS-CoV-2 Selenium SELENOF selenoprotein sequence shown target thioredoxin reductase transfected cells turn understanding virion production wild-type [DOI] 10.3389/fnut.2020.00143 PMC 바로가기 [Article Type] Nutrition