The coronavirus disease of 2019 pandemic-associated stress among medical students in middle east respiratory syndrome-CoV endemic area An observational studyObservational Study Published on 2021-01-222022-10-04 Journal: Medicine [Category] MERS, 임상, [키워드] acute respiratory syndrome affected alleviate anonymously Anxiety average avoidance clinically Community conducted coronavirus disease coronavirus disease of 2019 correlation COVID-19 COVID-19 pandemic cross-sectional disorder Distance learning endemic area facilitated facilitator Generalized healthcare hygiene information knowledge Measures medical students mental health middle east respiratory syndrome -CoV Mild moderate MOST pandemic Pandemics participant questionnaire Randomly receive reported resource returned risk factor selected significantly Stress Support syndrome [DOI] 10.1097/MD.0000000000023690 PMC 바로가기 [Article Type] Observational Study
Predictive Factors for Impaired Mental Health among Medical Students during the Early Stage of the COVID-19 Pandemic in MoroccoArticles Published on 2021-01-172022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, [키워드] alleviate Analysis Anxiety baseline conducted consequence COVID-19 COVID-19 pandemic Depression distress Enrollment Evidence Factor female female gender Generalized Impaired Insomnia Insomnia Severity Index Intervention Logistic regression Long-term follow-up median Mental mental health mental health issues Morocco multivariable logistic regression Odds ratio outcome Physicians Prevalence prevalence of COVID-19 PROTECT Psychiatric psychological condition Psychological distress psychological support Region reported risk factor scale Screening severe symptom Stage student Symptom Symptoms [DOI] 10.4269/ajtmh.20-1302 PMC 바로가기 [Article Type] Articles
COVID-19 Amplifiers on Health Inequity Among the Older PopulationsPublic Health Published on 2021-01-152022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] affecting aging alleviate amplifier cascade consequence coronavirus disease COVID-19 Health health equity help highlight knowledge Older older population Population populations public health policy reduction response social determinants Trigger triggers while [DOI] 10.3389/fpubh.2020.609695 PMC 바로가기 [Article Type] Public Health
The Mental Well-Being of Frontline Physicians Working in Civil Wars Under Coronavirus Disease 2019 Pandemic ConditionsPsychiatry Published on 2021-01-142022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] addition affecting alleviate Anxiety Burnout combating condition coronavirus disease COVID-19 COVID-19 pandemic cross-sectional defined Depression Depressive symptoms displaying distress Emergency Emotional exhaustion event HADS health-care indicated inventory methodology pandemic pandemic (COVID-19) Patient physician Prevalence Psychological Satisfaction scale Stress Stressor working [DOI] 10.3389/fpsyt.2020.598720 PMC 바로가기 [Article Type] Psychiatry
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 수용체 결합 도메인을 표적으로 하는 치료 중화 항체Article Published on 2021-01-122022-09-10 Journal: Nature Communications [Category] 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate alleviation angiotensin angiotensin converting enzyme animal model antibodies antibody Antibody therapy Antibody-dependent enhancement block caused Clinical symptoms Complex crystal structure convalescent convalescent patient coronavirus COVID-19 COVID-19 patient crystal structure D614G variant enzyme evaluated hamster human monoclonal antibodies Human monoclonal antibody Infection Interaction mAb mAbs mononuclear cell mononuclear cells neutralize neutralizing antibody Orientation pandemic Peripheral blood Peripheral blood mononuclear cells RBD receptor Receptor binding domain reduce reduction in Region reported respiratory rhesus SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein Symptom the SARS-CoV-2 therapeutic therapeutic effect therapeutic effects Therapeutics Vaccine Viral viral infection viral spike protein viral titer [DOI] 10.1038/s41467-020-20602-5 PMC 바로가기 [Article Type] Article
Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug TransportersArticle Published on 2021-01-092022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] ABC affected affecting alleviate anti-COVID-19 agents anti-inflammatory compounds anticancer antimalarial Antiviral compound APP-Binding Cassette (ABC) transporters applied Chloroquine Compound COVID-19 pandemic drug drug combination Effect examined Favipiravir Health in vitro functional studies In vitro studies Interaction model systems OATP transporters Patient Potential Remdesivir Repurposed drug Repurposed drugs Ritonavir significantly the disease tissue Toxicity transporter treated variety [DOI] 10.3390/pharmaceutics13010081 PMC 바로가기 [Article Type] Article
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)Research Article Published on 2021-01-082022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] acute respiratory distress airway alleviate antiviral agent ARDS Bank COVID-19 drug Drug repurposing drugs exploration faster hACE2 hACE2 receptor human Angiotensin-converting enzyme immune system in vitro in vivo indication Infection Inflammation Influenza virus inhibit inhibitor Interaction investigated modulate molecular molecular docking pandemic peptide peptide-based pharmacological potential benefit predict predicted Prevent protein-protein interaction receptor reduced Regulatory required SARS-CoV-2 spike protein specificity Spike protein stimulate Support syndrome the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Treatment viral infection [DOI] 10.1371/journal.pone.0245258 PMC 바로가기 [Article Type] Research Article
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infectionsArticle Published on 2021-01-072022-10-04 Journal: Cell Death & Disease [Category] 진단, [키워드] Activation administration alleviate anti-inflammatory property biological processe Bronchoalveolar lavage fluid chemokine circulating co-culture co-cultured Concentration correlated counteract COVID-19 patients disease severity Effect Host implication in viral in vitro indicate Inflammation Inflammatory diseases Inflammatory response Influenza inhibiting innate immune response Interleukins lung Lung injury Lymphocytes Macrophage MAPK microenvironment mitigate neutrophil NF-κB signaling Pathways Pneumonia pro-inflammatory cytokine pulmonary inflammation reduced respiratory epithelial cell Respiratory tract diseases respiratory viral infection respiratory viral infections shown significantly Stat1 STAT3 therapeutic therapeutic target transcriptomic virus [DOI] 10.1038/s41419-020-03283-2 PMC 바로가기 [Article Type] Article
Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet™ Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory ResponsesMolecular Biosciences Published on 2021-01-072022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] alleviate Anti-inflammatory anti-SARS-CoV-2 therapeutics AutoDock vina blocked combat complex correlated Cys145 docking drugs Dynamics FIVE fraction functional food Health help Hyperinflammatory hyperinflammatory responses IL1β IL6 IL6R indicated Inflammatory cytokine Interaction M pro main protease molecular molecular docking molecular dynamics non-toxic Oleaceae oleuropein olive oil olive secoiridoids Precision predicted Prevent protease receptor Replication residue response RMSD S protein SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike (S) protein stability structures supported the S protein the SARS-CoV-2 therapy TNFR1 TNFα viral disease virtual search [DOI] 10.3389/fmolb.2020.627767 PMC 바로가기 [Article Type] Molecular Biosciences
The Effect of Exogenous Surfactant on Moderate and Severe Stages of COVID-19 Induced ARDS: the Pilot Study of a Clinical TrialOriginal Article Published on 2021-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] alleviate alveolar cells Analysis ARDS Blood clinical Clinical outcome clinical trial control arm COVID-19 COVID-19 adult patients COVID-19 pandemic COVID-19 patient COVID-19 patients dose Effect Effects Exogenous Face mask form Health ICU induced Inflammatory Intubated lung dysfunction moderate P/F ratio Patient pilot study Potential treatment potential treatments previous study pulmonary involvement severe COVID-19 significantly Stage surfactant treatment arm trials virus with COVID-19 [DOI] 10.22037/ijpr.2021.115390.15347 PMC 바로가기 [Article Type] Original Article