Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans미토콘드리아와 식단 사이의 상호 작용은 Caenorhabditis elegans에서 병원체와 스트레스 저항을 매개합니다Research Article Published on 2019-03-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect alleviation Amino acid amino acid metabolism Anemia arise B12 bacterial pathogen Bacterial pathogenesis Bacterial pathogens biochemical Caenorhabditis canonical clearance cofactor condition Critical Defense deficiency demonstrated diet E . coli elegan elegans excess exhibited exposure to Genetic Health homeostasis Host host defense improvement Improvements Increasing independent independent of Interaction intermediate knockdown Laboratory Loss metabolism methylmalonyl-CoA microbiota mitochondrial mitochondrial dysfunction neurological defects organism overexpression pathogen pathogenic Pathogens Pathways phenotype physiological propionate RNAi-mediated gene sensitivity Stress Support survival susceptibility variety vitamin B12 vitamin B12 deficiency were used worm worms [DOI] 10.1371/journal.pgen.1008011 PMC 바로가기 [Article Type] Research Article
Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in micearticle Published on 2018-10-312024-09-01 Journal: International Journal for Parasitology [Category] 말라리아, [키워드] artesunate clearance Mathematical modelling mefloquine phagocytes Plasmodium berghei [Article Type] article
Sequence features governing aggregation or degradation of prion-like proteins프리온 유사 단백질의 응집 또는 분해를 제어하는 서열 특징Research Article Published on 2018-07-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation aliphatic Alzheimer’s disease Amino acid amino acid sequence amino acids Amyotrophic lateral sclerosis aromatic residue aromatic residues asparagine cellular classical clearance complex interplay control systems correlated Degradation Diseases domain domains dose-dependent elicited enhanced eukaryotic evade Factor Factors feature Features Frequency Genetic genetic screen Glutamine glycine highlight hnRNPA1 human protein human proteins increase in intrinsic Lateral Sclerosis lead neurodegenerative disorder neurodegenerative disorders occur Prevent promote promoted Protein protein quality control Proteins Quality control recognize recognizing residue second sequence stimulate subset suppressed to define variety while yeast [DOI] 10.1371/journal.pgen.1007517 PMC 바로가기 [Article Type] Research Article
A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoVVaccines and Antiviral Agents Published on 2018-06-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activity antibody Antiviral antiviral therapeutics binding binding site C-terminal clearance conformational conserved Critical cross-neutralization cross-neutralize cross-neutralizing domain Efficacy epitope Epitopes exhibited expressed expression feasibility high affinity Human humanized in vivo infect Infection mapped MERS-CoV MERS-CoV infection MERS-CoV RBD mice Middle East nanobody Neutralizing novel potent potential limitation produced producing Prophylactic PROTECT protective efficacy RBD receptor Receptor-binding domain recognizing renal residue respiratory respiratory syndrome coronavirus significantly Spike protein Spread strain targeting tested the RBD the receptor-binding domain therapeutic agents therapeutic efficacy Treatment yeast [DOI] 10.1128/JVI.00837-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivoarticle Published on 2017-12-312024-09-01 Journal: International Journal for Parasitology [Category] 말라리아, [키워드] Artemisinin clearance drug action in vivo malaria mefloquine Plasmodium berghei [Article Type] article
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation말단 부속기 단백질 CEP164에 대한 조건부 녹아웃 마우스는 기도 다중섬모 세포 분화에서 필수적인 역할을 밝힙니다Research Article Published on 2017-12-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affecting airway airways arising Arl13b Asthma basal body binding Brain Cby1 Cell cell differentiation cells CEP164 cerebrospinal fluid characterized chronic obstructive ciliary ciliary dyskinesia circulation clearance component Control COPD Critical cystic fibrosis develop differentiation disease disorder distal docking dysfunction dyskinesia Evidence female reproductive tract fiber fibrosis fluids Genetic genetic disease GTPase Health human biology hydrocephalus implicated Infection infertility knockout mice lack lining male male infertility membrane vesicle membrane vesicles mice modulate molecular mechanism molecular mechanisms Mucociliary clearance Mucus multicilia oviduct Patient Perturbation physiological primary ciliary dyskinesia primary culture Protein Proteins provide recruitment regulate Regulation respiratory respiratory diseases selective Structure Symptom Testis tissue tracheal Transport unique Vesicle while [DOI] 10.1371/journal.pgen.1007128 PMC 바로가기 [Article Type] Research Article
The microbiota protects against respiratory infection via GM-CSF signaling미생물군은 GM-CSF 신호 전달을 통해 호흡기 감염으로부터 보호합니다Article Published on 2017-11-152022-09-14 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 폐렴구균 감염증, [키워드] Actinobacteria activate activating airway alveolar macrophage Bacteria Bacteroidetes clearance Clostridium Defense defined ENhance Enterococcus Extracellular firmicutes GM-CSF Gut Host human pathogen identify identity Immunity Increased Infection interleukin-17A intestinal killing Klebsiella pneumoniae lactobacillus lung Lung infection mechanisms mice microbiota pathogen promote PROTECT Proteobacteria regulate respiratory infection Signaling Staphylococcus aureus Staphylococcus epidermidis stimulate Streptococcus pneumoniae [DOI] 10.1038/s41467-017-01803-x PMC 바로가기 [Article Type] Article
A dominant-negative mutant inhibits multiple prion variants through a common mechanism우성-음성 돌연변이는 공통 메커니즘을 통해 여러 프리온 변이체를 억제합니다Research Article Published on 2017-10-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amyloid cells chaperone chaperones clearance conformation conformational conformations curing daughter cells determine determined by disorders dominant-negative dosage doses Effect fiber human disease inhibit inhibited inhibitor inhibitors interfere Intervention kinetic Lower mechanism mode molecular mutant observation overcome pathway persistence phenotype Phenotypes plasticity prion Protein protein conformations reported resulting sensitivity shown specificity stability unique variant variants [DOI] 10.1371/journal.pgen.1007085 PMC 바로가기 [Article Type] Research Article
Host-mediated impairment of parasite maturation during blood-stage Plasmodium infectionArticle Published on 2017-07-182024-08-27 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] clearance malaria Mathematical modelling parasite maturation. Plasmodium berghei ANKA
[A cohort study on the epidemiological characteristics of HBeAg sero-clearance in HBeAg positive chronic hepatitis B patients in Jiangsu province from 2012 to 2014]Article Published on 2017-02-102023-06-16 Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Category] B형 간염, [키워드] clearance Cohort HBV Hepatitis B e antigen [DOI] 10.3760/cma.j.issn.0254-6450.2017.02.009