Towards reduction in bias in epidemic curves due to outcome misclassification through Bayesian analysis of time-series of laboratory test results: case study of COVID-19 in Alberta, Canada and Philadelphia, USAResearch Article Published on 2020-06-062022-10-28 Journal: BMC Medical Research Methodology [Category] COVID-19, Fulltext, SARS, [키워드] 95% confidence interval Accuracy adjusted Analysis applied assumption Bayesian analysis Bayesian approach Bias analysis Canada clinical setting Contagion COVID-19 degrade Diagnosis diagnostic Epidemic evaluate examined extreme information knowledge Laboratory Laboratory test misclassification error outcome Philadelphia reduction in Result SARS-COV-2 infection SARS-CoV-2 viral infection self-isolate sensitivity Sensitivity and specificity Simulation specificity surveillance data tested the epidemic Uncertainty Under-diagnosis USA widespread [DOI] 10.1186/s12874-020-01037-4 PMC 바로가기 [Article Type] Research Article
Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling studyArticle Published on 2020-06-022022-10-29 Journal: The Lancet. Public Health [Category] COVID-19, [키워드] 95% prediction interval acute respiratory syndrome Admission basic reproduction number Characteristics Combination Contact coronavirus COVID-19 COVID-19 cases Critical care death deaths decrease early stage Effect effective England Epidemic extreme finding funding Health Service health-care hospital ICU ICUs Intensive intensive care unit Intervention Ireland lockdown measure median Medical Research Council Older Patient physical distancing Prevent proportion reduce reducing repeated required SARS-CoV-2 Self-isolation shielding Support symptomatic cases the epidemic Transmission Transmission model Treatment Trigger [DOI] 10.1016/S2468-2667(20)30133-X PMC 바로가기 [Article Type] Article
Flattening the Mental Health Curve: COVID-19 Stay-at-Home Orders Are Associated With Alterations in Mental Health Search Behavior in the United StatesOriginal Paper Published on 2020-06-012022-10-31 Journal: JMIR Mental Health [Category] COVID-19, [키워드] alteration Anxiety Behavior change changes in Concentration coronavirus coronavirus disease COVID-19 Depression Effects extreme fatigue flattening Google Government health information needs ideation implementation infodemiology infoveillance Insomnia irritability measure mental health National objective pandemic participant Prevent produced quarantine reduce Research Result search trends searched social contact social distancing Spread Stay-at-home orders suggested Suicide sustained Symptom the United State The United States Transmission Variation Washington [DOI] 10.2196/19347 PMC 바로가기 [Article Type] Original Paper
Drug repositioning is an alternative for the treatment of coronavirus COVID-19Research article Published on 2020-06-012022-10-05 Journal: International journal of antimicrobial agents [Category] SARS, 신약개발, 치료법, 치료제, [키워드] caused coronavirus COVID-19 COVID-19 disease drug extreme pandemic pharmacological treatment raised repositioning SARS-CoV SARS-CoV-2 therapeutic Treatment [DOI] 10.1016/j.ijantimicag.2020.105969 [Article Type] Research article
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate modelReport Published on 2020-05-292022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome animal model bronchiolar cause ciliated epithelial cell Clinical sign Comparative coronavirus coronavirus disease Coronaviruses COVID-19 cynomolgus macaque Diffuse alveolar damage disease drug treatment Effectiveness extreme foci Human human coronavirus humans Infection Influenza inoculated intestinal tract Isolation Like lung lesion Lung pathology macaque macaques MERS MERS-CoV infection Middle East nasal nasal mucosa nose and throat Older pandemic coronavirus Pathogenesis pathogenesis of COVID-19 pathology Patient peaked pneumocyte provide SARS-CoV SARS-CoV infection SARS-CoV infections SARS-CoV-2 SARS-COV-2 infection Science severe symptom Symptoms syndrome Therapeutic strategies type I type II pneumocytes upper respiratory tracts Vaccine virus [DOI] 10.1126/science.abb7314 PMC 바로가기 [Article Type] Report
Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19Review Published on 2020-05-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Activation acute lung injury acute respiratory distress acute respiratory syndrome adjuvant adjuvant treatment administration amplified Anti-inflammatory Antiviral antiviral activities antiviral environment ARDS cause characterized Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 pathology COVID-19 patients Cytokine storm death delivery drug concentration effective Efficacy extreme fenretinide immune response immunomodulating Infection Inflammation Inflammatory response Inflammatory responses lung Pathologies progression pulmonary pulmonary delivery pulmonary inflammation SARS-CoV-2 SARS-COV-2 infection standard treatment subsequent syndrome therapeutic therapeutic intervention therapy Toxicity Treatment triggering utility Vaccine [DOI] 10.3390/ijms21113812 PMC 바로가기 [Article Type] Review
Longer incubation period of coronavirus disease 2019 (COVID‐19) in older adultsOriginal Article Published on 2020-05-222022-10-28 Journal: Aging Medicine [Category] COVID-19, [키워드] Adults age Chinese confidence interval coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 Diagnosis elderly patients extreme implication Incubation period median median age objective Older Older adults Patient patients previous study recruited released Result returned symptom onset Travel [DOI] 10.1002/agm2.12114 PMC 바로가기 [Article Type] Original Article
COVID-19: The Inflammation Link and the Role of Nutrition in Potential MitigationReview Published on 2020-05-192022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adopted Affect affecting Anti-inflammatory Anti-inflammatory therapy cardiovascular disease caused characterized chronic lung diseases complications coronavirus country COVID-19 COVID-19 infection COVID-19 pandemic CVD Diabetes Mellitus disease distress extreme food group Government hygiene immune function Immunocompromised include Infection Inflammation lockdown Mitigation Noncommunicable Diseases novel coronavirus disease nutrition nutritional status obesity other disease outcome pandemic Patient Potential Prevent protocol public health respiratory infections risk factor role SARS-CoV-2 severe COVID-19 Severe COVID-19 Infection severe COVID-19 infections Severe infection social distancing Spread Support susceptible systemic inflammation the cytokine storm the patient Vitamin C Vitamin D Zinc [DOI] 10.3390/nu12051466 PMC 바로가기 [Article Type] Review
Investigating the genomic landscape of novel coronavirus (2019-nCoV) to identify non-synonymous mutations for use in diagnosis and drug designArticle Published on 2020-05-152022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV Amino acid amino acid change Analysis antiviral therapies Bat-hCoV Care combinatorial treatment coronavirus death Diagnosis drug drug design Efficacy effort explain extreme feature Genome genomic group HCoV Health identify indicated infecting inhibitory isolate lack Mutation Non-synonymous Non-synonymous mutation nonsynonymous substitution novel Novel coronavirus nucleotide nucleotide substitution Occurrence other coronaviruses Pangolin-hCoV Pathogenesis pathogenicity Patient Phylogenetic analysis Phylogeny Protein resulting SARS SARS-CoV2 similarity Spike protein Substitution synonymous Synonymous and non-synonymous substitutions therapy Treatment Vaccine viral genome Viral protein virus [DOI] 10.1016/j.jcv.2020.104441 PMC 바로가기 [Article Type] Article
Probable Exit Strategy Against COVID-19 of Low Resource Country like Nepal: Open Floor DiscussionView Point Published on 2020-04-302022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] COVID-19, SARS, [키워드] exit strategy Against approach average consequence Contact tracing country COVID-19 disrupting distress effective exit extreme extreme social distancing floor Follow-up Infection Isolation lifted lockdown maintain Nepal reopening SARS-CoV-2 second wave severity Spread Strategy Trial virus [DOI] 10.31729/jnma.4974 PMC 바로가기 [Article Type] View Point