interferon – Page 33 – Communicable Diseases Research

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

Perspective

Published on 2022-01-142022-10-28
Journal: Pathogens [Category] COVID-19,

Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cells

SARS-CoV-2-특이적 T 세포를 정량화하고 표현형을 지정하기 위한 신속하고 간소화된 전혈 기반 다중 매개변수 분석

Article

Published on 2022-01-132022-09-11
Journal: The European Respiratory Journal [Category] Fulltext, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Blood CD4 CD4 T-cell Cell cells convalescent coronavirus COVID-19 detectable Differentiated cells evaluate flow cytometry granzyme healthcare worker IFN-γ Immunity indicated interferon memory MONITOR natural infection Necrosis participant Participants PCR-negative Peripheral blood phenotype protective immunity Rapid Rapid tests reported symptoms representing respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Symptom T-cell T-cell Response T-cell responses T-cells tested trials tumour necrosis factor tumour necrosis factor-α Vaccine Vaccine-induced immunity Whole blood
[DOI] 10.1183/13993003.00285-2021 PMC 바로가기 [Article Type] Article

Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon Pathway

Immunology

Published on 2022-01-132022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, MERS,

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells

인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가

Research Article

Published on 2022-01-132022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종, 신약개발, 치료제,

[키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection
[DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article

Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients

Research Article

Published on 2022-01-122022-10-28
Journal: Aging Cell [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

[키워드] age aging Analysis Antiviral C‐reactive protein Cell cell interaction cellular immunology Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical D‐dimer decreased expression Defense deficiencies deficiency defined disease severity elevated epidemiological data exacerbate expression Factor IFITM3 IFNAR1 Immune cell immune response Immunity incidence individual individuals Inflammation Inflammatory marker interferon Laboratory testing LY6E Lymphocyte count macrophages molecular biology of aging morbidity and mortality naïve neutrophil–lymphocyte ratio Older pathophysiologic patients performed populations reduce reduced SARS‐CoV‐2 SARS‐CoV‐2 secretory cell severity significantly TRIM22 type I Viral load
[DOI] 10.1111/acel.13544 PMC 바로가기 [Article Type] Research Article

The adaptation of SARS-CoV-2 to humans

SARS-CoV-2의 인간 적응

Review

Published on 2022-01-102022-09-10
Journal: Memórias do Instituto Oswaldo Cruz [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation adaptive adaptive evolution addition antibodies anticipated autophagy Cell coronavirus death Defense Depletion escape Evidence functions Host host cell host cells Human Immunity immunogenic impairment include inhibiting interferon lymphocyte Mitochondria motifs Mutation mutation and variants occurred other coronaviruses overcome process of adaptation replicate resource respiratory respiratory tract SAR-CoV-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus triggering Usage Viral Viral RNA viral RNA detection virus
[DOI] 10.1590/0074-02760210127 PMC 바로가기 [Article Type] Review

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

흰 족제비에서 SARS-CoV-2 감염의 연령 의존적 병원성 특성

Article

Published on 2022-01-102022-09-12
Journal: Nature Communications [Category] SARS, 진단, 치료기술,

[키워드] activated T cells age Characteristics clinical symptom Clinical symptoms Contact COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity direct contact ferret ferrets gene expression profile group groups healthy Human individuals infected with SARS-CoV-2 Infection inflammatory cell inflammatory cell infiltration interferon lung Macrophage macrophage responses manifestation mimicking nasal not differ Older Pathogenesis pathogenesis of SARS-CoV-2 pathogenic Patient reveal SARS-CoV-2 SARS-COV-2 infection Seroprevalence severe COVID-19 patients severe symptom severe symptoms severely infected patients significantly T cells Transcriptome transcriptome analysis transcriptomic profile Transmission type I interferon Viral host response viral loads Viral transmission virus while
[DOI] 10.1038/s41467-021-27717-3 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3

SARS-CoV-2 스파이크는 인터페론 조절 인자 3을 표적으로 하여 선천적인 항바이러스 면역을 길항합니다

Cellular and Infection Microbiology

Published on 2022-01-102022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome Analysis antiviral immune response biochemical blocked Cell cells Co-expression analysis control cells Corona virus COVID-19 COVID-19 pathogenesis cytokine Cytokines disease disease severity downstream ectopic expression evade experiment expressing expression expression of SARS-CoV-2 facilitate Factor Genes Host IFN-I IFNβ immunoassay immunoassays indicated infections inhibitor Innate innate immune response Innate immunity interferon interferon regulatory factor IRF3 mechanism NF-κB Pathogenesis Pattern recognition pattern recognition receptor proteasomal degradation Protein remained respiratory RIG-I RIG-I antiviral RNA SARS-CoV-2 SARS-CoV-2 spike Severe Acute Respiratory Syndrome Corona Virus Signaling spike Stat1 stimulated suppressed targeting the SARS-CoV-2 transcription factor type I interferon Viral viral burden Viral RNA virus Virus Disease virus infections
[DOI] 10.3389/fcimb.2021.789462 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection

생존한 고령 환자들은 SARS-CoV-2 감염 후 수개월 동안 세포 및 체액 면역학적 기억이 보존됨을 보여줍니다

Article

Published on 2022-01-072022-09-11
Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-N antibodies anti-N antibody anti-N IgG anti-S anti-S IgG antibodies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determined by donors effective ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Fewer patient Fewer patients granzyme B had more heterogeneity hospital Humoral response IFN-γ IgG1 immune responses Immunity Immunological memory immunosenescence in some infected individuals Infection interferon interferon-γ life lymphocyte Lymphocytes memory memory B memory B cell memory B cells memory B lymphocytes memory T memory T lymphocytes Month Older pandemic Patient Peripheral blood positively correlated preserved producer cell quantified recovered patient reduce resolved respiratory respond response responses robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom show Specific specific antibodies specific immunity T lymphocyte T lymphocytes understanding Vaccination strategies virus were measured
[DOI] 10.1093/gerona/glab206 PMC 바로가기 [Article Type] Article

Body composition, physical capacity, and immuno-metabolic profile in community-acquired pneumonia caused by COVID-19, influenza, and bacteria: a prospective cohort study

Article

Published on 2022-01-052022-10-04
Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] 95% CI acute respiratory syndrome Admission Analysis Bacteria Bacterial Body body composition body mass C-reactive protein caused characterized community-acquired pneumonia coronavirus coronavirus disease COVID-19 cytokine diabetes etiology fat-free mass Glucose groups handgrip strength hemoglobin hyperglycemia IFN-γ IL-10 IL-12p70 IL-18 IL-1β IL-5 IL-6 IL-8 Inflammation Inflammatory response Influenza interferon lipids low handgrip strength mean difference no difference not affect obesity pathogen Patient patients hospitalized patients with COVID-19 patients with influenza physical activity levels physical capacity Pre-diabetes prospective cohort study Prospective Study questionnaire respiratory virus Result SARS-CoV-2 the patient tumor necrosis factor-α Waist circumference were assessed were measured
[DOI] 10.1038/s41366-021-01057-0 PMC 바로가기 [Article Type] Article