Quit Experiences among Primary Care Patients Enrolled in a Smoking Cessation Pilot RCT Early in the COVID-19 PandemicRandomized Controlled Trial Published on 2021-01-242022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, 임상, [키워드] age analyzed benefit boredom change COVID-19 COVID-19 complication COVID-19 pandemic Effects enrolled experience finding groups increased risk individual Intervention interview Isolation medication Nicotine Older participant Patient primary care RCT reaction reported representing risk risk perceptions smoker smoking smoking cessation Stress tobacco use Trial trial participant while [DOI] 10.3390/ijerph18031011 PMC 바로가기 [Article Type] Randomized Controlled Trial
Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial중등도 또는 중증 COVID-19 환자에 대한 표준 치료와 함께 흡입 황산마그네슘의 효능 및 안전성 평가: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-182022-09-10 Journal: Trials [Category] 임상, [키워드] 1:1 acute severe asthma adjuvant therapy Administered Affect airway smooth muscle alveolar Anti-inflammatory anticipated Arm ARMS arterial blood arterial blood oxygen saturation arterial oxygen saturation arteriole Artery Asthma attack basic Blinding block Block randomisation blocks blood oxygen Blood oxygen saturation bradyarrhythmia calcium calcium antagonist cardiovascular disease cardiovascular diseases Chest computed tomography Chest CT chest CT scan clinical clinical impact clinical manifestation clinical manifestations Clinical studies clinical study clinical trials Combination Computed tomography Computer software Confirmed congestive heart failure Control Controlled trial cough COVID-19 criteria defined diagnosis of SARS-CoV-2 dissemination Dyspnoea Effect Effects Efficacy and safety eight element eligible patient Eligible patients excluded FIVE functional heart block hospital Hospital stay Hospitalized hospitalized patient hospitalized patients Hypoxemia hypoxia impairment IMPROVE improvement inclusion criteria induce Infection inhalation Inhaled Intervention intervention arm intravenous intravenously Length Lung injury lung involvement magnesium sulphate Mask moderate myocardial injury nasopharyngeal secretion National nebulized number objective Open-label outcome oxygen oxygen saturation Parallel Arm parenchyma participant Patient patients with moderate PCR performed polymerase chain polymerase chain reaction protocol pulmonary artery pulmonary involvement randomisation randomised randomised controlled trial randomization Randomly randomly divided RCT receive reduce Registered registration number registry respiratory respiratory airway respiratory airways Respiratory function respiratory tract respiratory tract symptoms Sample size SARS-COV-2 infection saturation severe COVID-19 Shortness of breath shown smooth muscle relaxant standard treatment status Study protocol supplementary material Symptom Tehran therapy Trial Trial registration Ventilation Version website with COVID-19 Yazd [DOI] 10.1186/s13063-021-05032-y PMC 바로가기 [Article Type] Letter
Traditional Chinese medicine Lianhua Qingwen for treating COVID-19 A protocol for a meta-analysis and systematic review of randomized controlled trialsCOVID-19 치료를 위한 중국 전통 의학 Lianhua Qingwen 무작위 대조 시험의 메타 분석 및 체계적인 검토를 위한 프로토콜3800 Published on 2021-01-152022-08-31 Journal: Medicine [Category] MERS, meta-analysis, 임상, [키워드] acute infectious diseases approach CBM Chinese citation clinical history Clinical outcome CNKI Cochrane Handbook Cochrane Library complex coronary pneumonia coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database effective Efficacy Efficacy and safety English Epidemic evaluate Evidence Fang Fatality rate global public health Handbook Infectious disease Infectious diseases Intervention lianhua qingwen life Medicine Meta-analysis outbreak Pathogenesis Pneumonia present protocol Randomized controlled trial Randomized controlled trials RCT Registration registration number reported Research Risk of bias Science systematic review TCM therapeutic effect Traditional Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 VIP Web of Science [DOI] 10.1097/MD.0000000000024204 PMC 바로가기 [Article Type] 3800
JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysisResearch Article Published on 2021-01-112022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] 95% CI Antiviral candidate Clinical outcome conducted controls Coronaviruses COVID-19 COVID-19 patient COVID-19 patients cytokine release discharge disease Efficacy estimate highly pathogenic hospital discharge Human ICU admission indicated infection control interferon interferon treatment investigator janus medRxiv Meta-analysis Mortality non-randomized novel Novel coronavirus pandemic positive Randomized RCT recipient reduced respiratory infection Result risk SARS-CoV-2 searched significantly significantly increased Spread standard treatment supplementary material systematic review therapy These data treated Treatment Treatment outcome trials Type type I interferon viral infection virus while [DOI] 10.1186/s12879-020-05730-z PMC 바로가기 [Article Type] Research Article
Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive DeclineArticle Published on 2021-01-072022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, [키워드] AgeWell.de aging analyses analyzed assessments average bandwidth baseline characteristics cardiovascular Cluster-randomized controlled trial cognitive Cognitive function conducted Consequences Controlled COVID-19 pandemic Decline Dementia dropped Effectiveness eligible Eligible participants engage FIVE general practitioner Germany groups impacted individuals Intervention lifestyle methodological Montreal not differ outcome participant Participants populations prevention primary care RCT recruited recruitment risk risk factor scored Sociodemographic factor study population Study protocol targeting Trial women [DOI] 10.3390/ijerph18020408 PMC 바로가기 [Article Type] Article
The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: A systematic review and meta-analysis of randomized trials코로나19 예방을 위한 하이드록시클로로퀸의 효능 및 안전성: 무작위 임상시험에 대한 체계적인 검토 및 메타분석Meta-Analysis Published on 2021-01-062022-09-10 Journal: PLoS ONE [Category] 임상, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse event adverse events antiviral properties antiviral property calculated CIs clinical clinical benefit Controlled controlled trials coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 determine did not reduce Efficacy and safety eligibility criteria Evidence HCW Health Organization healthcare worker Healthcare workers high risk higher risk Hospitalization Hydroxychloroquine in vitro increased the risk Meta-analysis moderate Mortality outcome pharmacologic prophylaxis pharmacological physical distancing Placebo Population Prophylactic Prophylaxis Randomized controlled trial Randomized controlled trials randomized trial RCT RCTs reduce registry relative risks respiratory risk RRs SARS CoV SARS CoV-2 searched Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus solution systematic review Transmission use of hydroxychloroquine World Health Organization [DOI] 10.1371/journal.pone.0244778 PMC 바로가기 [Article Type] Meta-Analysis
A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)Kampo 의약품을 사용한 COVID-19 예방에 대한 다기관, 무작위 대조 시험(RCT) 연구 프로토콜의 구조화된 요약(예방 연구에 의한 전염병에 대한 일본의 통합 관리: IMJEDI P1 연구)Letter Published on 2021-01-062022-08-31 Journal: Trials [Category] MERS, 임상, 치료제, [키워드] 1:1 administration age allergic Analysis appearance Arm ARMS assumed Asymptomatic balancing Blinding body temperature calculated capture cardiovascular disease Chain Reaction clinical clinical trials cloud condition Control control group cough COVID-19 diabetes disappearance dissemination doctor dosage dropout rate drug edema effective element Endpoint exclusion criteria failure Fever Final final analysis final analysis) Frequency group hands healthy history hospital Hospitalization hypertension hypokalaemia Hypothesis ICU Immunosuppressant immunosuppressants incidence of COVID-19 incidence rate incidence rates include inclusion criteria Infection infection rate Inflammation interim analysis interstitial pneumonia intervention group investigator Japan Japanese Kampo Kampo medicines liver dysfunction lung malaise management mechanical ventilation Medicine number numbness objective observation period oral administration oral administration) outcome package parallel-group participant Patient PCR PCR positive per day Period pharmaceutical Placebo placebo group Placebo tablets positive result power power of 80% pregnant Prevent Prophylactic prophylactic study protocol randomised Randomized Randomized controlled trial RCT receive recruited Registered Registration registry required Research respiratory respiratory diseases respiratory inflammation risk factor Risk factors Safety Sample size SARS-CoV-2 RNA secondary Secondary outcomes Shock Shortness of breath significantly skin rash sputum study drug study period Study protocol supplementary material Symptom Symptoms symptoms of COVID-19 Tablet Taking Taste the placebo group Trial Trial registration Two-arm university upper respiratory verification Viral viral infection Vital website [DOI] 10.1186/s13063-020-04939-2 PMC 바로가기 [Article Type] Letter
Virucidal effect of povidone iodine on COVID-19 in the nasopharynx: A structured summary of a study protocol for an open-label randomized clinical trial비인두에서 COVID-19에 대한 포비돈 요오드의 바이러스 살균 효과: 공개 라벨 무작위 임상 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 6 hour 6 hours acute renal failure adverse effect adverse effects adverse event adverse events anticipated Arm-1 ARMS assigned baseline being randomized Blinding both groups chronic renal failure clinical trial college comparator Concentration conducted confirmed case COVID-19 COVID-19 case COVID-19 virus creatinine criteria Data analysis diagnosed diet disease dissemination distilled water DMC Efficacy element eligibility assessment estimated glomerular filtration rate evaluate exclusion filtration rate Final glomerular filtration rate groups Identifier in both groups include Inclusion inclusion criteria independent Informed consent Intervention intervention arm intervention arms intervention group invasive involved Iodine KDIGO lactating masking Microsoft Excel Modification nasal Nasal Irrigation Nasal spray nasopharynx Noninvasive ventilation number objective Occurrence Open-label Other outcome parallel-group participant Patient performed Placebo positive Povidone Iodine pregnant women Primary outcome proportion protocol random number generation randomization Randomized randomized clinical trial RCT receive recruited Registered renal renal disease renal failure required routine care Sample size screened sealed secondary outcome sensitivity Seven single-center Stage statistician status Study protocol supplementary material Symptom Thyroid thyroid disease Trial trial protocol Trial registration Version virucidal virus website [DOI] 10.1186/s13063-020-04963-2 PMC 바로가기 [Article Type] Letter
The Weight of Evidence From Electrophysiology, Observational, and Cardiovascular End Point Studies Demonstrates the Safety of Azithromycin전기생리학, 관찰 및 심혈관 종말점 연구에서 얻은 증거의 무게는 아지스로마이신의 안전성을 보여줍니다Review Published on 2021-01-012022-09-11 Journal: Clinical and translational science [Category] SARS, 임상, [키워드] Analysis Azithromycin benefit-risk profile cardiac death cardiovascular clinically Combined coronary disease coronavirus disease Coronavirus disease 2019 COVID-19 death deaths electrocardiogram Electrocardiograms Electrophysiology End event Evidence finding Frequency heterogeneous higher risk Hydroxychloroquine incidence increase in Increased increased risk Infection Observational data observational studies observational study oral Patient pharmacodynamic studies Point QTc QTC prolongation Randomized controlled trial RCT RCTs Research research and development Safety sudden cardiac death unlikely weight [DOI] 10.1111/cts.12867 PMC 바로가기 [Article Type] Review
Randomised controlled trials for COVID-19: evaluation of optimal randomisation methodologies-need for data validation of the completed trials and to improve ongoing and future randomised trial designsCOVID-19에 대한 무작위 대조 시험: 최적의 무작위화 방법론 평가 - 완료된 시험의 데이터 검증 및 진행 중인 및 미래의 무작위 시험 설계 개선 필요Review Published on 2021-01-012022-09-11 Journal: International journal of antimicrobial agents [Category] 임상, [키워드] (coronavirus disease 2019 benefit Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 Dexamethasone disease severity group Guidance HCQ Health Organization high mortality hospitalised COVID-19 patient Hydroxychloroquine IMPROVE Lopinavir Lopinavir/ritonavir methodology Metrics Mortality NIH Ordinal Scale outcomes pandemic patients randomisation randomised controlled trial Randomised trial RCT RCTs recovery RECOVERY trial reduced Remdesivir risk reduction Ritonavir sampling errors seven-point ordinal scale severity solidarity the disease Time to recovery treat Treatment Trial trials utilised WHO World Health Organization [DOI] 10.1016/j.ijantimicag.2020.106222 PMC 바로가기 [Article Type] Review