registry – Page 33 – Communicable Diseases Research

Deficiencies in Planning Interventional Trial Registration of COVID-19 in China

Medicine

Published on 2021-03-312022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

COVID-19 중증 환자의 임상 및 생화학적 매개변수에 대한 오메가-3 지방산 보충제의 효과: 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-03-292022-08-13
Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 임상,

[키워드] albumin arterial pH arterial pressure assigned base excess baseline Bicarbonate biochemical marker biochemical parameter Blood cells blood glucose Blood urea nitrogen calcium carbon dioxide clinical clinical study clinical trials collected Coma conducted control group coronavirus creatinine Critically ill Critically ill patient critically ill patients Date double-blind Effect fatty Fatty acid fatty acids fortified Glasgow coma scale Glucose groups HCO HCT hematocrit hemoglobin immune system infected with COVID-19 Inflammatory inflammatory and biochemical markers Intervention intervention group Kidney function mean arterial pressure n3-PUFA n3-PUFAs name nitrogen no significant difference no significant differences O2sat omega-3 Omega-3 fatty acids Omega-3 polyunsaturated fatty acids omega-3 supplementation oxygen parameter partial pressure Partial pressure of oxygen partial thromboplastin time Patient phosphorus Platelet Plt Polyunsaturated Potassium randomized clinical trial Randomly Registered Registration registration number registry renal function respiratory and renal function Respiratory function Result scale significant differences significantly higher sodium survival rate THROMBOPLASTIN Trial two groups urea viral infections WBCs White blood cell White blood cells with COVID-19
[DOI] 10.1186/s12967-021-02795-5 PMC 바로가기 [Article Type] Randomized Controlled Trial

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

Oncology

Published on 2021-03-252022-10-31
Journal: Frontiers in Oncology [Category] COVID-19,

[키워드] 95% CI adjusted Adverse adverse outcome age age and sex Analysis Bone marrow Cancer cancer patient Cancer patients cancer treatment cause Cell COVID-19 COVID-19 disease death diagnosed diagnosed with COVID-19 drug estimate Factor Fatality rate higher risk hospital identify increased risk intensive and critical care intensive care less Multivariate analysis Norway outcome Patient patients patients treated population-based prescription Ratio registry Result retrieved risk factor SARS-COV-2 infection SARS-CoV-2 positive patient significantly increased study period suggested System treated Treatment
[DOI] 10.3389/fonc.2021.652535 PMC 바로가기 [Article Type] Oncology

Outcomes and Risk Factors Associated With SARS-CoV-2 Infection in a North American Registry of Patients With Multiple Sclerosis

Research

Published on 2021-03-192022-10-30
Journal: JAMA Neurology [Category] COVID-19, Fulltext, MERS,

[키워드] 95% CI acute illness Admission age ambulatory Analysis asked black Black race cardiovascular comorbidities Care Characteristics clinical Clinical outcome Clinical severity clinician Cohort Community Comorbidity Corticosteroid Corticosteroids COVID-19 COVID-19 disease course COVID-19 infection cross-sectional Data collection death disease emergence exposure Factor female finding Health Health care helping Hospitalization Hospitalized identification identify Importance IMPROVE information initial symptom intensive care Male sex measure morbidity and mortality Multiple multiple sclerosis North objective observé Odds ratio Older age Other outcome overall mortality participant Patient patients Point professional registry Relevance reported required Result risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sclerosis setting Support Treatment ventilator white with COVID-19
[DOI] 10.1001/jamaneurol.2021.0688 PMC 바로가기 [Article Type] Research

Predicting the outcome of COVID-19 infection in kidney transplant recipients

Research Article

Published on 2021-03-192022-10-28
Journal: BMC Nephrology [Category] COVID-19, SARS,

[키워드] Admission age AKI ALT Analysis analyzed AST Characteristics Clinical findings Clinical outcome Cohort collected conducted COVID-19 COVID-19 infection CRP demographic demographic characteristics died ferritin Follow-up ICU ICU admission in-hospital mortality independent risk factor independent variable initial Invasive mechanical ventilation ischemic heart disease Kidney injury kidney transplant recipient Kidney transplantation laboratory parameter LDH Lymphocyte count lymphopenia Mortality multicenter multivariable analysis nine Older outcome over Patient patients patients hospitalized Primary outcome reached recipient registry renal replacement therapy required Result Retrospective study RRT secondary outcome serum albumin serum creatinine Serum ferritin severe COVID-19 significantly the patient treatment strategy Turkey with COVID-19
[DOI] 10.1186/s12882-021-02299-w PMC 바로가기 [Article Type] Research Article

Efficacy of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis arising as a sequelae in convalescent COVID-19 patients: a randomized multicenter trial

회복기 COVID-19 환자의 후유증으로 발생하는 폐 섬유증에 대한 현대 의학 및 한약 조합의 효능: 무작위 다기관 시험

Clinical Trial

Published on 2021-03-182022-09-10
Journal: Infectious Diseases of Poverty [Category] SARS, 임상, 치료제,

[키워드] (pirfenidone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered affected affecting age arising candidate caused Chinese Chinese Clinical Trial Registry clinical clinical manifestation clinical manifestations Combination conducted control group control groups convalescent coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 cases Critical critical condition deficiency determine Effectiveness eligible expiratory expiratory vital capacity feasible fibrosis IMPROVE Inclusion indicated infected patient infected patients lead life Lung function manifestation modern medicine mortalities Mortality multicenter Multicenter trial parallel-group participant Patient patients Pirfenidone Placebo Prospective clinical trial Prospective trial Psychology pulmonary pulmonary fibrosis Quality of life Randomized receive recorded reducing Registered registry reported respiratory SARS-CoV-2 SARS-COV-2 infection SASR-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly syndrome TCM the disease Traditional Chinese medicine Treatment treatment group Trial registration two groups vital capacity Well-being
[DOI] 10.1186/s40249-021-00813-8 PMC 바로가기 [Article Type] Clinical Trial

Interleukin-6 blocking agents for treating COVID-19: a living systematic review

COVID-19 치료를 위한 인터루킨-6 차단제: 살아있는 체계적인 검토

Meta-Analysis

Published on 2021-03-182022-09-11
Journal: The Cochrane database of systematic reviews [Category] 임상, 진단,

[키워드] 95% CI adverse event adverse events age all-cause mortality anti-IL6 approach articles available data average baseline benefit Bia blocking agent blocking agents Brazil can not Care certainty certainty of evidence China clinical Clinical improvement Cochrane COVID-19 Study Register collected data conducted coronavirus disease Coronavirus disease 2019 COVID-19 Critical Critical disease Data collection death defined disease disease severity Efficacy and safety eight evaluate evaluated Evidence excluded FIVE Follow-up France Health Organization heterogeneity hospital discharge identify IL-6 IL-6 blocking Immune system dysfunction immunosuppressive incidence Inclusion individual individual patient data meta-analyses Inflammation interleukin interleukin 6 interleukin 6 (IL-6 Intubated intubated patient intubated patients Italy male mechanical ventilation Meta-analysis methodology Mild moderate Mortality multicentre nine no increase not intubated organ support Other outcomes outcome outcomes oxygen participant Participants Patient patient data patients with COVID-19 peer-reviewed people with COVID-19 Placebo platform Platform trial progression proportion protocol randomised randomised controlled trial Randomised controlled trials ranged RCT RCTs reduce Registered registry reported risk of bia Safety sarilumab score searched Selection Serious Adverse Event Serious Adverse Events Seven severe coronavirus disease severity siltuximab standard care Standard of care subgroups of patient systematic review Tocilizumab Tolerance Treatment Trial trial participant trial participants trials unlikely USA WHO World Health Organization
[DOI] 10.1002/14651858.CD013881 PMC 바로가기 [Article Type] Meta-Analysis

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

Clinical Trial

Published on 2021-03-162022-10-04
Journal: The New England Journal of Medicine [Category] Fulltext, SARS, 변종, 임상, 진단,

[키워드] 1:1 501Y.V2 95% CI 95% confidence interval acute respiratory syndrome African age Analysis analyzed assessment assigned AZD1222 B.1.351 B.1.351 variant caused ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical conducted coronavirus Coronavirus 2019 D614G dose double-blind Efficacy end point enrolled foundation greater groups HIV HIV-negative Human immunodeficiency virus incidence laboratory-confirmed less median age Melinda Gate Mild-to-moderate multicenter Neutralization assay Pan participant Placebo placebo recipient placebo recipients Population primary end point primary end-point pseudovirus randomized, controlled trial receive recipient registry Result SARS-CoV-2 SARS-CoV-2 variant second dose Serious Adverse Event serum sample show protection against Sodium chloride South Africa symptomatic tested the vaccine two-dose regimen Vaccine variant viral particle virus
[DOI] 10.1056/NEJMoa2102214 PMC 바로가기 [Article Type] Clinical Trial

Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation

Observational Study

Published on 2021-03-142022-10-05
Journal: European heart journal [Category] 임상,

Clinical Trial Data Sharing for COVID-19–Related Research

COVID-19 관련 연구를 위한 임상 시험 데이터 공유

Viewpoint

Published on 2021-03-122022-09-10
Journal: Journal of Medical Internet Research [Category] SARS, 임상,

[키워드] absence adjust approaches assessment assumption baseline bias challenge clinical Clinical research clinical trial clinical trials conducted control group cooperation COVID-19 COVID-19 pandemic Culture data data-sharing dataset Definition develop Diseases error event false-negative False-positive feasibility group heterogeneity Inconclusive interoperability Intervention lack likelihood linear Meta-analysis outcome measures outcomes pandemic Patient Perspective plethora privacy public health random-effect recruitment reductions in Registered registry reported Research risk factor sample size calculation Sample size calculations Scientific community security service statistical Statistical power statistically Structure total sample size Treatment Trial trials
[DOI] 10.2196/26718 PMC 바로가기 [Article Type] Viewpoint