SARS-CoV-2 spike – Page 33 – Communicable Diseases Research

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위

420

Published on 2021-09-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단,

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

천연 stilbenoid (-)-Hopeaphenol은 SARS-COV-2 USA-WA1/2020, B.1.1.7 및 B.1.351 변이체의 세포 진입을 억제합니다.

Antiviral Agents

Published on 2021-09-202022-09-10
Journal: Antimicrobial Agents and Chemotherapy [Category] 변종,

[키워드] ACE2 ACE2 binding activities activity addition Alpha analogue angiotensin Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 Beta binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay pseudovirus assays RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective selectivity index small molecule Small molecules stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell Vero-E6 cells Viral viral entry viral spike VSVΔG
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antiviral Agents

Published on 2021-09-202022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19,

[키워드] ACE2 activity addition analogue Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective small molecule stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell viral entry viral spike
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antiviral Agents

Published on 2021-09-202022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] ACE2 activity addition analogue Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective small molecule stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell viral entry viral spike
[DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents

Discovery and Characterization of Spike N-Terminal Domain-Binding Aptamers for Rapid SARS-CoV-2 Detection

신속한 SARS-CoV-2 검출을 위한 스파이크 N-말단 도메인 결합 압타머의 발견 및 특성화

Article

Published on 2021-09-202022-09-11
Journal: Angewandte Chemie (International ed. in English) [Category] MERS, SARS, 진단, 치료기술, 치료제,

SARS-CoV-2 spike linear epitope scanning via a peptide microarray through sera profiling

혈청 프로파일링을 통한 펩타이드 마이크로어레이를 통한 SARS-CoV-2 스파이크 선형 에피토프 스캐닝

Article

Published on 2021-09-172022-09-12
Journal: STAR protocols [Category] SARS, 진단,

Exploiting genomic surveillance to map the spatio-temporal dispersal of SARS-CoV-2 spike mutations in Belgium across 2020

Article

Published on 2021-09-172022-10-04
Journal: Scientific Reports [Category] Coronavirus, SARS, 변종, 유전자 메커니즘,

COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study

수유 여성의 COVID-19 mRNA 백신 및 항체 반응 : 전향 적 코호트 연구

Clinical Trial

Published on 2021-09-172022-08-09
Journal: BMC Pregnancy and Childbirth [Category] SARS, 바이오마커, 임상, 진단,

[키워드] antibodies in breastmilk antibodies transfer via breastmilk antibody antibody quantification Antibody Response antibody transfer association Blood BNT162b2 BNT162b2 Pfizer vaccine Breastfeeding breastmilk change clinical Clinical data clinical trial conducted convenience homogenous sample COVID-19 COVID-19 vaccination dominant dominant serum antibody response enrolled evidence of healthcare worker house human milk IgA IgG IgG antibodies IgM immunity after vaccination immunization immunological characteristics immunological profile in-house ELISA lactating lactating women lactation levels of antibody moderate mother mRNA vaccination mRNA vaccine positive post vaccination presence of antibody prospective cohort study quantified questionnaire Registered reported Result SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 trimeric spike protein serum antibody response shown Spike protein titer titers titers of IgG transfer Trimeric spike protein vaccination was performed women
[DOI] 10.1186/s12884-021-04051-6 PMC 바로가기 [Article Type] Clinical Trial

Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection

Research Article

Published on 2021-09-172022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 Analysis Anti-SARS-CoV-2 Activity Anticoagulant anticoagulation aPTT, activated partial thromboplastin time AT, antithrombin binding BoSG, sulfated galactan from the red alga Botryocladia occidentalis characterized chondroitin composed computational simulation conformational change CS, chondroitin sulfate cytotoxic effects demonstrated DMEM, Dulbecco's modified Eagle medium domain DS, dermatan sulfate Effect FDA, US Food and Drug Administration FucCS, fucosylated chondroitin sulfate fucosylated chondroitin sulfate GAG, glycosaminoglycan GlcA, D-glucuronic acid glycan glycans HS, heparan sulfate HSQC, heteronuclear single quantum coherence IbFucCS, FucCS isolated from Isostichopus badionotus IbSF, I. badionotus-derived sulfated fucan Interaction kinetic LvSF, sulfated fucan from the sea urchin Lytechinus variegatus MD, molecular dynamics Molecular modeling mutant N501Y NMR nuclear magnetic resonance occur oligosaccharide Potential treatment PpFucCS, FucCS from the sea cucumber Pentacta pygmaea RBD RBD binding RBD, receptor-binding domain S-protein SA, streptavidin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SF, sulfated fucan SG, sulfated galactan SGP, spike glycoprotein SPR, surface plasmon resonance Structure sulfated surface plasmon resonance UFH, unfractionated heparin viral inhibition wildtype
[DOI] 10.1016/j.jbc.2021.101207 PMC 바로가기 [Article Type] Research Article

Saliva SARS-CoV-2 Antibody Prevalence in Children

Research Article

Published on 2021-09-152022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

[키워드] 95% CI 95% confidence interval Adults antibodies antibody Antibody detection Antibody Response Antigen antigens assays calculated children circulating circulating antibodies combined use COVID-19 COVID-19 patient enzyme-linked immunosorbent evaluate evaluated exploratory heterogeneity Humoral immunity IgA IgG investigated Luminex assay medical service mucosal multiple antigen Netherland Netherlands nucleocapsid Other Prevalence public health ranged RBD Receptor binding domain Saliva SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2-specific IgG serum specificity suggested the SARS-CoV-2 Vaccine
[DOI] 10.1128/Spectrum.00731-21 PMC 바로가기 [Article Type] Research Article