Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral Lactobacillus plantarumNutrition Published on 2021-12-222022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] Lactobacillus plantarum accquired immunity adjuvant administration Analysis antibody apoptotic BAL boost Bronchoalveolar lavage Combination COVID-19 COVID-19 pandemic effective Efficacy gut-lung axis immune immune response Immunity immunization inflammatory pathways interferon signaling lactobacillus memory memory immunity mucosal Neutralization antibody oral Probiotics promote promoted respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific immune response sera spleen systemic T-cell Response unique vaccination Vaccine [DOI] 10.3389/fnut.2021.789242 PMC 바로가기 [Article Type] Nutrition
SARS-CoV-2 spreads through cell-to-cell transmissionSARS-CoV-2는 세포 간 전파를 통해 확산423 Published on 2021-12-222022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, 진단, [키워드] (alpha (Beta ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B.1.1.7 B.1.351 Beta Cell cell-to-cell transmission cell–cell fusion Contact contribute convalescent sera coronavirus COVID-19 pandemic COVID-19 patients Critical cultures Efficiency endosomal entry ENhance enzyme Evidence feature impair implication Implications Infection inhibitor lentiviral mechanism membrane fusion neutralization neutralizing antibody Pathogenesis Pseudotyped virus reflects required respiratory responsible Result reveal SARS-CoV SARS-CoV spike SARS-CoV-2 SARS-CoV-2 spike sensitivity sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance spike glycoprotein Spike protein Spread the spike protein Transmission transmission of SARS-CoV-2 Treatment vaccinee variants of concern Viral viral cell VoC VOCs while wild type [DOI] 10.1073/pnas.2111400119 PMC 바로가기 [Article Type] 423
Evaluation of Three Quantitative Anti-SARS-CoV-2 Antibody Immunoassays3가지 정량적 항-SARS-CoV-2 항체 면역분석법의 평가Research Article Published on 2021-12-222022-09-10 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] (Abbott Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers Antigen binding antibodies caused Chemiluminescent assay convalescent plasma coronavirus correlated correlation COVID Critical detect determine DiaSorin ELISA evaluated herd immunity house identify IgG Immunity immunization immunoassay Infection International international standard less LIAISON Live virus monoclonal antibodies Neutralization assay Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers NIBSC not correlated pandemic performed Postinfection proportional bias Protective respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 strain sensitivities sensitivity sera serological Serological assay serological assays serological result serological results severe acute respiratory syndrome Coronavirus significantly Specificities specificity spike tested the immunoassay the SARS-CoV-2 Treatment vaccination virus neutralization assay virus neutralization assays Virus spike WHO [DOI] 10.1128/spectrum.01376-21 PMC 바로가기 [Article Type] Research Article
Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccinationSARS-CoV-2 Lambda 변이체의 단일 클론 항체 및 감염 및 백신 접종에 의해 유도된 중화 항체에 대한 감수성 감소Coronaviruses Published on 2021-12-212022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adenovirus Amino acid Analysis antigenicity average C.37 Calu Calu-3 caused Cell cell line cell lines convalescent convalescent sera convalescent serum coronavirus D614G demonstrated distribution Efficacy eight geographic location geographic locations immunized Inactivated vaccine Infection Lambda Lambda variant monoclonal antibodies monoclonal antibody mRNA vaccines multiple mutation multiple mutations Mutation mutations neutralization neutralization ability Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies pandemic pseudovirus pseudoviruses R126 Receptor binding domain reduced reduction in reference strain respiratory SARS-CoV-2 sensitivity sera severe acute respiratory syndrome coronavirus 2 South America Spike protein temporal distribution the SARS-CoV-2 the spike protein titre vaccination Vaccine Vaccines variant Viral were used [DOI] 10.1080/22221751.2021.2008775 PMC 바로가기 [Article Type] Coronaviruses
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron유사형 SARS-CoV-2 변이체 오미크론의 유의미한 면역 탈출Coronaviruses Published on 2021-12-212022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha BA.1 Beta convalescence serum Convalescent patients COVID-19 convalescent patient COVID-19 infection COVID-19 vaccines D614G Delta ED50 elicited finding Gamma Immune escape immune protection in vitro indicated infected with SARS-CoV-2 Lambda lead Mutation neutralization neutralization activity omicron Omicron variant other variant other variants Protein pseudotyped pseudotyped SARS-CoV-2 Pseudotyped virus reference strain SARS-CoV-2 SARS-COV-2 infection sensitivity sera serum sample serum samples Spike protein susceptibility the mean the Spike Vaccine variant variants variants of interest viruses VoC VOCs VOIs was tested [DOI] 10.1080/22221751.2021.2017757 PMC 바로가기 [Article Type] Coronaviruses
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infectionArticle Published on 2021-12-182022-10-04 Journal: Cell Discovery [Category] 비임상, [키워드] acute respiratory syndrome adenoviral vector Adenovirus adenovirus-based antibody B.1.1.7 lineage B.1.351 Biological techniques CD8 Cell coronavirus COVID-19 detectable effective Efficacy elicit elicited expressing full-length global pandemic glycoprotein heterologous prime-boost heterologous prime-boost immunization Immune cell immunization immunology intramuscular Lineage Lungs memory mice neutralizing antibody potent Prevent prime immunization produced profile Protective protective antibodies protective immunity provided regimen regimens responses robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera serotype Single-cell RNA sequencing T cell T cell responses the vaccine transmembrane spike Vaccine vaccine candidate [DOI] 10.1038/s41421-021-00360-4 PMC 바로가기 [Article Type] Article
Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants이종 Chadox1 NCOV-19 및 BNT162B2 프라임-부스트 백신 접종은 유능한 SARS-COV-2 변이체에 대한 강력한 중화 항체 반응 및 T 세포 반응성을 유도합니다.Clinical Trial Published on 2021-12-172022-08-13 Journal: EBioMedicine [Category] SARS, 변종, 임상, 진단, [키워드] addition Administered Adverse reactions All participants Alpha analysed antibody titres ART Arts B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta BNT162b2 boost CD4 CD8 Cellular immune response cellular immune responses ChAdOx1 ChAdOx1 nCoV-19 Cohort Course COVID-19 COVID-19 vaccination Delta dominant elicit elicited European evaluate finding followed by foundation funding Gamma Germany Heterologous heterologous vaccination homologous Horizon humoral immune immune responses Immunity immunogenic Immunological response immunological responses individual induce Lower median mRNA-based vaccine mRNA-based vaccines nCoV neutralization neutralized Neutralizing activity Neutralizing antibody response no difference offer P.1 participant peptide peptides prevalent Protective reactive reactivity reactogenicity receiving recognize regimen Research resulting retained Robert Koch SARS-CoV-2 spike peptide SARS-CoV-2 variant SARS-CoV-2 variants Science sera Serious Adverse Event Serious Adverse Events serological data significantly Symptom T cell T cells tested titre union vaccination variant variants variants of concern Wuhan Wuhan-Hu-1 [DOI] 10.1016/j.ebiom.2021.103761 PMC 바로가기 [Article Type] Clinical Trial
Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA AssayProtocol Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy ACE2 added addition Angiotensin converting enzyme-2 binding binding domain binding inhibition assay co-occurrence competitive ELISA condition Containment measure containment measures Control correlated cross-reactivity detect detection Efficacy ELISA ELISA assay high throughput immune include initial interactions Live virus live viruses murine neutralization Neutralization assay Neutralizing non-specific parameter plaque reduction neutralization Precision Prevent protocol R 2 RBD RBD-ACE2 reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike secondary antibody sensitive sensitivity sera serum soluble ACE2 specificity Spike protein stages Treatment Vaccine development validation Virus neutralization VNT [DOI] 10.3390/vaccines9121493 PMC 바로가기 [Article Type] Protocol
Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission routeSARS-CoV-2 B.1.351 변이체에 의한 야생형 마우스 감염은 가능한 새로운 종간 전파 경로를 나타냅니다Article Published on 2021-12-142022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] accompanied addition angiotensin angiotensin-converting enzyme 2 animal model antiviral inhibitor antiviral inhibitors B.1.351 binding affinity caused Contact COVID-19 COVID-19 pathogenesis Cross-species transmission Cytokines direct contact elevated enzyme Epidemic evaluate expand expressed Genetic modifications host range human population human populations increase indicate Infection Infectious diseases lung Lungs mACE2 mice Modification Mutation pathological change Proinflammatory cytokine proinflammatory cytokines RBD Receptor-binding domain regulated replicated SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant sera Spike protein strain susceptible the receptor-binding domain the SARS-CoV-2 tracheas Transmission transmission of SARS-CoV-2 Vaccines variant Viral viral infection wild-type zoonotic disease [DOI] 10.1038/s41392-021-00848-1 PMC 바로가기 [Article Type] Article
Calibration of two validated SARS-CoV-2 pseudovirus neutralization assays for COVID-19 vaccine evaluationCOVID-19 백신 평가를위한 두 개의 검증 된 SARS-COV-2 슈도 바이러스 중화 분석의 교정Comparative Study Published on 2021-12-142022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies approach assays Biomarker calibrated calibration convalescent sera COVID-19 COVID-19 vaccine COVID-19 vaccines Decision-making Efficacy evaluate Health Organization Immunoglobulin international standard licensure mRNA mRNA-1273 NAb NAb titers NAbs Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody observé overcome performed Phase 3 SARS-CoV-2 neutralization SARS-CoV-2 pseudovirus sera Standard Trial United State United States Vaccine vaccine efficacy vaccinee Vaccines World Health Organization’ [DOI] 10.1038/s41598-021-03154-6 PMC 바로가기 [Article Type] Comparative Study