The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 InfectionReview Published on 2020-08-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activate Activation adverse effect Affect antioxidant antioxidants cellular chronic inflammation COVID-19 Defense disease symptom exercise expression fasting Free radicals genetics Host immune system Immunity Importance increased mortality Inflammation Innate innate immune Local lung Lung disease mechanism microenvironment molecules obesity occur oxidative oxidative damage oxidative stress pandemic of COVID-19 protein A redox reduce regimens SARS–CoV-2 Scientific community shown status surfactant protein A the disease underlying diseases weight loss [DOI] 10.3390/antiox9090784 PMC 바로가기 [Article Type] Review
Risk factors and outcome of COVID-19 in patients with hematological malignanciesResearch Published on 2020-08-252022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] 95% CI 95% confidence interval age Allogeneic Analysis autologous Blood C-reactive protein cancer patient Cell Corticosteroid COVID-19 COVID-19 in patient COVID-19 mortality CRP defined disease status driven by Factor Hematological malignancies Hematological malignancy hospital immune Inflammation laboratory-confirmed SARS-CoV-2 infection large cohort Logistic regression low dose lower mortality multicenter neutropenia Older age outcome overall mortality parameter Patient PCR assay pediatric performance status recipient Result retrospective severe COVID-19 Spain Spanish Stem cell transplantation therapy Treatment [DOI] 10.1186/s40164-020-00177-z PMC 바로가기 [Article Type] Research
Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study)염증이 고조된 SARS-CoV-2 관련 심근 손상에서 심장 및 호흡 기능의 악화를 감소시키는 카나키누맙(Covid-19 심장 손상에서의 카나키누맙: 3개의 C 연구)Trial Designs Published on 2020-08-242022-09-10 Journal: Clinical Cardiology [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] anticipated baseline characteristics C‐reactive protein canakinumab cardiac cardiac injury Characteristics Controlled trial COVID‐19 CRP defined Deterioration discharge dysfunction elevated Elevation elevations enrolled evaluate hospital Hospitalized hospitalized COVID‐19 patients hyperlipidemia hypertension Hypothesis IMPROVE Inflammation male median morbidity morbidity and mortality Mortality myocardial injury occur Ordinal Scale outcome Patient Placebo Prevalence Prevent primary endpoint progressive respiratory failure randomization Randomized controlled trial randomized patient reduce Respiratory failure Respiratory function Result SARS‐CoV‐2 SARS‑CoV2 SARS‐CoV2 infection SARS‐CoV‐2 secondary endpoint Seven Time to recovery Treatment troponin troponin T worsening [DOI] 10.1002/clc.23451 PMC 바로가기 [Article Type] Trial Designs
Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 InfectionArticle Published on 2020-08-242023-06-15 Journal: Critical Care Medicine [Category] MERS, SARS, [키워드] human albumin Inflammation Mortality Prognosis [DOI] 10.1097/CCM.0000000000004613 PMC 바로가기
Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation systemReview Published on 2020-08-242023-06-15 Journal: Blood reviews [Category] MERS, SARS, [키워드] Coagulation COVID-19 Inflammation SARS-CoV2 thrombosis [DOI] 10.1016/j.blre.2020.100745 PMC 바로가기 [Article Type] Review
Clinical Features of COVID-19 Patients with Diabetes and Secondary HyperglycemiaResearch Article Published on 2020-08-242022-10-29 Journal: Journal of Diabetes Research [Category] COVID-19, MERS, SARS, [키워드] age CD3+ CD4+ CD8+ cells cell count cell counts Chinese clinical Clinical characteristics clinical manifestations Committee correlated COVID-19 COVID-19 patient Critical CT finding CT findings defined diabete diabetes diabetic patient diagnosed diagnostic enrolled exhibited feature higher risk IL-6 immune response increased risk infections Inflammation LDH male mechanisms Mild mild case Older Pathogenesis Patient positive positively correlated Prognosis progression proportion Registered risk factor SARS-CoV-2 secondary secondary hyperglycemia Severe case severity severity of COVID-19 significantly higher Spearman correlation analysis subject Symptom the disease Treatment two groups [DOI] 10.1155/2020/3918723 PMC 바로가기 [Article Type] Research Article
Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently NeededReview Published on 2020-08-242022-10-30 Journal: Nutrients [Category] COVID-19, MERS, [키워드] acute lung injury acute respiratory syndrome adverse effect Anti-inflammatory anti-oxidative Anxiety ARDS Care caused clinical Clinical features Clinical outcome clinical trial clinical trials contribute coronavirus Coronaviruses COVID-19 COVID-19 pandemic critical care patient Cytokine storm death disease distress effective Evidence exaggerated immune response excessive inflammation Health homogenous humans immune response imperative individual Inflammation melatonin pandemic of COVID-19 Pathogenesis pathology patients professional progression reducing reported respiratory disorder safety profile SARS-CoV-2 Sedation subsequent syndrome Treatment triggering vascular permeability [DOI] 10.3390/nu12092561 PMC 바로가기 [Article Type] Review
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?Opinion Published on 2020-08-242022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] accelerate accelerated acute respiratory disease ARDS co-morbidities condition COVID-19 COVID-19 pandemic Cytokine storm syndrome elicited frailty Hospitalization hyperinflammatory state ICU care individual individuals inflammaging Inflammation Inflammatory pandemic Perspective post-COVID-19 patient public health question respiratory resulting survivor susceptibility syndrome systemic inflammation worsening [DOI] 10.1186/s12979-020-00196-8 PMC 바로가기 [Article Type] Opinion
Clinical features of rheumatic patients infected with COVID-19 in Wuhan, ChinaArticle Published on 2020-08-222023-06-16 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, [키워드] Autoimmune diseases Autoimmunity Inflammation [DOI] 10.1136/annrheumdis-2020-217627 PMC 바로가기
PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19Immunology Published on 2020-08-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 airway allergic diseases angiotensin-converting enzyme 2 Antiviral approaches Cardiovascular function Central nervous system COVID-19 demonstrated drug ebastine Epidemic faster global public health Idelalisib IL-1β IL-6 IL-8 increase in Infection Inflammation inflammatory reaction inhibition inhibitors lung mitigate Mortality Patient PI3K Potential potential therapeutic target pro-inflammatory cytokines pro-inflammatory factor receptor reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 pandemic Spread suppress T cells target therapeutic therapy TNF-α Treatment upper respiratory tract virus [DOI] 10.3389/fimmu.2020.02094 PMC 바로가기 [Article Type] Immunology