The impact of obesity on severe disease and mortality in people with SARS‐CoV‐2: A systematic review and meta‐analysisReview Article Published on 2020-08-142022-10-31 Journal: Endocrinology, Diabetes & Metabolism [Category] COVID-19, [키워드] 95% CI 95% CIs 95% confidence interval accompanied Adiposity Admission age Analysis association body mass index CIs Clinical outcome Cochrane Library Cohort COVID‐19 COVID‐19 patient Disseminated intravascular coagulation ectopic eligible excess explained fat functional group heterogeneity increased risk Inflammation Measures Mortality obesity observational study Older Older age outcome Patient prospective cohort study public health messaging raised random effect Result retrospective cohort study risk risk factor SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease statistical systematic review Venous Thromboembolism Web of Science [DOI] 10.1002/edm2.176 PMC 바로가기 [Article Type] Review Article
Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin SystemImmunology Published on 2020-08-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Administered Admission age ambient C-reactive protein C1 esterase inhibitor Case series Chest Clinical improvement complement complement system Computed tomography Concentration Conestat alfa Contact contact activation system Controlled clinical trial COVID-19 declined dose dysregulated immune response Efficacy elevated Evidence hyperinflammation Immediate Inflammation inflammatory cascade Inflammatory marker intervals Intravenous injection Kallikrein-kinin system Level lung involvement majority mechanical ventilation median Nasopharyngeal swab occurred oxygen saturation oxygen supplementation Patient patients potential benefit preventing disease progression progressive disease regulator required Safe SARS-CoV-2 severe coronavirus disease severe COVID-19 severe COVID-19 patients Severe COVID-19 pneumonia Switzerland System treated Treatment University Hospital Basel [DOI] 10.3389/fimmu.2020.02072 PMC 바로가기 [Article Type] Immunology
Potential therapeutic application of mesenchymal stem cell-derived exosomes in SARS-CoV-2 pneumoniaReview Published on 2020-08-142022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory syndrome affecting anti-inflammatory effect ARDS article Biomarker carried Cell characteristic Combination coronavirus country cytokines trigger edema effective antiviral treatment Efficacy Exosome Exosomes function Health induce Inflammation Inflammatory cytokines lung management Mesenchymal stem cells new virus outbreak Potential pulmonary fibrosis Result SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2 virus infection searched secretion selected stem cells syndrome the patient therapeutic tissue regeneration Treatment Vaccine virus pneumonia [DOI] 10.1186/s13287-020-01866-6 PMC 바로가기 [Article Type] Review
Clinical Characteristics and Risk Factors for Disease Severity and Death in Patients With Coronavirus Disease 2019 in Wuhan, ChinaMedicine Published on 2020-08-132022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission age CD19 CD3 CD4 CD4 cell Cell clinical clinical manifestation collected data Comorbidities Comorbidity conducted COVID-19 COVID-19 case Cox model Cytokines D-dimer death Deterioration diabete died disease deterioration elevated Factor Fever High-sensitivity C-reactive protein hypertension IL-10 IL-6 immune response immune responses Inflammation interleukin-10 IQR lactate dehydrogenase LDH Leukocytosis lymphocyte lymphopenia manifestation men Neurological symptom neutrophil Next-generation sequencing Older age organ dysfunction outcome Patient patients Pneumonia progressed progression progression of disease Renmin Hospital respiratory symptom Retrospective study risk factor Risk factors RT-PCR severity statistical analysis the disease the median university Wuhan Wuhan, China [DOI] 10.3389/fmed.2020.00532 PMC 바로가기 [Article Type] Medicine
Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protectionReview Published on 2020-08-132022-10-30 Journal: Microcirculation (New York, N.Y. : 1994) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome affected ARDS Brain Capillaries circulation coronavirus coronavirus disease COVID‐19 COVID‐19 dysfunction endothelial Endothelial cell endothelial injury exacerbate glycocalyx homeostasis increasingly Infection Inflammation inflammatory disease Injury liver lung multiple organs organs rapid increase severity Symptom syndrome systemic disease therapeutic target thrombosis thrombotic Vascular Vascular endothelium Vasculitis [DOI] 10.1111/micc.12654 PMC 바로가기 [Article Type] Review
The Interrelation of Neurological and Psychological Symptoms of COVID-19: Risks and RemediesReview Published on 2020-08-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] affected affective Anxiety association Brain Central nervous system COVID-19 COVID-19 pandemic Critical Depression disorders disseminate distress events Health healthcare healthy individual highlight illness illnesses impacted increase in increasingly Inflammation Injury long-lasting management Mental mental health nervous system neurological Neurological symptom Novel coronavirus Obsessive-compulsive disorder Panic Perspective potential mechanism Psychological psychological symptoms remedy resulting SARS-COV-2 infection Symptoms [DOI] 10.3390/jcm9082624 PMC 바로가기 [Article Type] Review
Hazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: ReviewReview Published on 2020-08-132022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] Activation acute respiratory syndrome Antiviral Care Case report cause caused Cohort studies Convalescent plasma therapy coronavirus coronavirus disease COVID-19 COVID-19 pandemic criteria Critically ill cytokine Cytokine storm develop disease severity early stage early treatment elevated eligible excessive cytokine response hazard Health immunology Inflammation Inflammatory cytokine Inflammatory response interferon-γ lack literature review mechanically ventilated meta-analyses monocyte morbidity and mortality Mortality mortality rate multidimensional objective pandemic Patient patients with COVID-19 positive feedback loop Protein Research Result review SARS-CoV-2 severity shown storm Support supportive care systematic reviews systemic inflammation target the cytokine storm therapy Treatment virus was performed with COVID-19 [DOI] 10.2196/20193 PMC 바로가기 [Article Type] Review
Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal InfectionC-반응성 단백질에 의한 보체 활성화는 폐렴구균 감염으로부터 마우스를 보호하는 데 중요하다.Original Research Published on 2020-08-132024-07-31 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] acute phase response C-reactive protein complement Inflammation pneumococcal infection [DOI] 10.3389/fimmu.2020.01812 PMC 바로가기 [Article Type] Original Research
Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus FruitsReview Published on 2020-08-132022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Citrus sinensis acute respiratory syndrome antiviral action applied approach bind binding energy caused Cell Citrus citrus fruits complex component Computational methods coronavirus Coronavirus disease 2019 COVID-19 Diseases dose Effect effective Efficacy epidemiological food fruit function Health hesperidin immune system Infection Inflammation Laboratory LIGHT modulating New oxidative stress oxygen free radical potential benefit pp1a protease Protein researchers responsible Ritonavir SARS-CoV-2 Support sweet orange triggered viral disease viral replication virus virus and oxidative stress virus infection Vitamin C [DOI] 10.3390/antiox9080742 PMC 바로가기 [Article Type] Review
Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting ImplicationsArticle Published on 2020-08-132022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] 3D structure ACE2 acetylcholine receptors agonist Amino acid cell entry cell receptors cholinergic COVID-19 COVID-19 patients docking experiment domain dysregulation enzyme examined Extracellular form homolog homologous hospitalized COVID-19 patients Hypothesis identification implicated Inflammation Interaction modelled structure molecular neurotoxin Nicotine Nicotinic Cholinergic System observation pathophysiology performed Potential Prevalence PROTECT raise receptor SARS-CoV-2 sequence smoking spike subunit System targeting the SARS-CoV-2 the Spike therapeutic toxin virus while [DOI] 10.3390/ijms21165807 PMC 바로가기 [Article Type] Article