SARS-CoV2 – Page 34 – Communicable Diseases Research

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

호중구는 Covid-19 뇌졸중 환자에서 뇌 혈전의 면역 시그니처를 우세합니다.

Multicenter Study

Published on 2022-02-012022-09-10
Journal: Acta Neuropathologica Communications [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술,

[키워드] ACE2 expression cells Chain Reaction characterized complement complex conducted Control control patients controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients docking Endovascular treatment Evidence expressed expression level Factor Features FIBRIN immune signature increased risk infected with COVID-19 Ischemic Stroke large vessel lymphocyte macrophages molecular Monocytes monocytes/macrophage monocytes/macrophages mortality rates MPO NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils pathological analysis Patient patients Platelet Platelets polymerase chain polymerase chain reaction Ratio receptor ACE2 red blood cells retrieved ROC analysis SARS-CoV-2 SARS-CoV2 Sequencing severity stroke supplementary material the SARS-CoV-2 thrombi thrombosis thrombotic Thrombotic events Thrombus von Willebrand factor
[DOI] 10.1186/s40478-022-01313-y PMC 바로가기 [Article Type] Multicenter Study

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Article

Published on 2022-02-012022-10-27
Journal: Antiviral Research [Category] COVID-19,

Efficacy and safety of colchicine treatment in patients with COVID-19: A prospective, multicenter, randomized clinical trial

Randomized Controlled Trial

Published on 2022-02-012023-07-08
Journal: Phytotherapy research : PTR [Category] COVID19(2023년),

[키워드] clinical trial Colchicine COVID-19 SARS-CoV2
[DOI] 10.1002/ptr.7319 [Article Type] Randomized Controlled Trial

SARS-CoV2 Vaccination Adverse Events Trend in Italy: A Retrospective Interpretation of the Last Year (December 2020–September 2021)

Article

Published on 2022-01-302022-10-28
Journal: Vaccines [Category] COVID-19,

Vitamin D regulation of immune function during covid-19

Article

Published on 2022-01-292022-10-28
Journal: Reviews in Endocrine & Metabolic Disorders [Category] Coronavirus, COVID19(2023년), Fulltext, SARS,

[키워드] Activation adaptive Adaptive immunity airway epithelia alveolar Alveolar macrophages calcitriol Cathelicidin Cell chemokine clearance CYP27B1 cytokine Cytokine storm dead demonstrated dysregulation ENhance enzyme epithelia Express expresse help immune immune cells immune function infect Infection innate immune system Innate immunity investigated Ligand Local Lower respiratory tract lung macrophages mechanism metabolite modulating morbidity and mortality pandemic pathogen pathway pneumocyte producing Proinflammatory cytokine Proinflammatory response pulmonary Pulmonary alveolar macrophage reduce Regulation released respiratory pathogen rising SARS-CoV2 shown subsequent VDR viral infection viral neutralization virus Vitamin D Vitamin D receptor
[DOI] 10.1007/s11154-021-09707-4 PMC 바로가기 [Article Type] Article

Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19

낮은 수준의 과립구 골수 유래 억제 세포는 중증 COVID-19 환자의 추적 관찰에서 생존의 좋은 지표가 될 수 있습니다

Observational Study

Published on 2022-01-282022-09-12
Journal: Frontiers in Immunology [Category] 임상, 진단,

Trends and Risk Factors of In-Hospital Mortality of Patients with COVID-19 in Germany: Results of a Large Nationwide Inpatient Sample

Article

Published on 2022-01-282022-10-28
Journal: Viruses [Category] COVID-19,

Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

Research

Published on 2022-01-272022-10-31
Journal: Genome Medicine [Category] COVID-19, SARS,

[키워드] ACE2 Administered airway epithelial cell analyzed Antiviral compound antiviral drug antiviral therapy Cell cell interaction cell line component coronavirus Coronavirus infection Coronavirus replication COVID-19 pandemic CRISPR CRISPR screen death EDC4 effective vaccine expand expressing Factor functional globe HEK293 HEK293T Host human coronavirus OC43 identify Infection involved knockdown knowledge mRNA pathway Pathways performed promote Regulation reported representing Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV2 supplementary material target Vero Vero E6 website were used while XRN1
[DOI] 10.1186/s13073-022-01013-1 PMC 바로가기 [Article Type] Research

An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution

Article

Published on 2022-01-272022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] 95% CI acquisition activated acute phase Analysis analyzed anti-SARS-CoV-2 antibody AUC Cell mediated immunity Comorbidities Course COVID-19 COVID-19 patient Critical Diagnosis disease Diseases evaluate event Evolution Factor flow cytometry form four group healthy controls Hospitalization identify imbalanced immune response immune response Immunity immunological independent Infection inflammatory parameters less pathology Patient predominant progression protective factor Randomized response robust SARS-CoV-2 infected individual SARS-CoV2 severe COVID-19 patient severity specificity subset Symptomatic patients T helper T-cell T-cell subsets T-cells Th1 Th1 immunity Th1 response Th17 Th2 the disease the SARS-CoV-2
[DOI] 10.3390/biomedicines10020296 PMC 바로가기 [Article Type] Article

RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections

COVID-19 환자의 RNA 시퀀싱은 호중구 활성화 바이오 마커를 감염을위한 유망한 진단 플랫폼으로 식별합니다.

Research Article

Published on 2022-01-262022-09-10
Journal: PLoS ONE [Category] 바이오마커, 치료기술,

[키워드] abundance analyzed Asymptomatic Biomarker Biomarkers Blood Cell controls COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DAPI DEFA1 Deterioration diagnostic disease disease severity Elastase Host identify immune increased expression increases in Infection intensive care intensive care unit involved moderate disease NETs neutrophil neutrophil activation Neutrophil elastase Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils nuclear DNA patients plasma platform reductions in respiratory RNA RNA sequencing SARS-CoV2 SARS-CoV2 infection sensitivity severe disease severity of COVID-19 staining Support syndrome T cell T cell receptor TCR transcript Transcriptome transcripts Viral viral infection Viremia virus was measured Whole blood
[DOI] 10.1371/journal.pone.0261679 PMC 바로가기 [Article Type] Research Article