SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19코로나19 외래환자의 SARS-CoV-2 중화항체 LY-CoV555Clinical Trial Published on 2021-01-212022-09-14 Journal: The New England Journal of Medicine [Category] Fulltext, SARS, 신약개발, 임상, 진단, [키워드] 95% CI 95% confidence interval accelerate acute respiratory syndrome assigned baseline cause clinical outcomes coronavirus coronavirus disease decrease diagnosed dose end point evaluated Hospitalization in viral interim analysis life-threatening log LY-CoV555 Mild moderate monoclonal antibody NCT04427501 neutralizing antibody Outpatient Patient phase 2 trial Placebo predicted Prevent Primary outcome Quantitative Randomly receive reduce reported SARS-CoV-2 severity of symptom single intravenous infusion Smaller Symptoms the patient the placebo group Viral load Viral RNA [DOI] 10.1056/NEJMoa2029849 PMC 바로가기 [Article Type] Clinical Trial
System models for resilience in gerontology: application to the COVID-19 pandemicReview Published on 2021-01-142022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] Academy accelerate Adults Care Cognitive function complement COVID-19 pandemic determine Factor Frame health system IMPROVE individual level methodology physical populations produced Quality of life required Resilience resource risk risk reduction Science Shock Stressor System [DOI] 10.1186/s12877-020-01965-2 PMC 바로가기 [Article Type] Review
System models for resilience in gerontology: application to the COVID-19 pandemicReview Published on 2021-01-142022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, [키워드] Academy accelerate Adults Care Cognitive function complement COVID-19 pandemic determine Factor Frame health system IMPROVE individual level methodology physical populations produced Quality of life required Resilience resource risk risk reduction Science Shock Stressor System [DOI] 10.1186/s12877-020-01965-2 PMC 바로가기 [Article Type] Review
In silico exploration of novel protease inhibitors against coronavirus 2019 (COVID-19)Research article Published on 2021-01-142022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료제, [키워드] accelerate ADME ADME studies affected analyzed antiviral properties Antiviral treatment applied approaches binding energy binding free energy can be used complex Compound compounds Coronavirus 2019 COVID-19 Critical docked drug Drug discovery fluctuation Health in-silico indicate Infection inhibitor inhibitors Interaction main protease MD simulation medium MM/PBSA molecular docking Molecular dynamics simulation MPro much higher performed probe protease Protease inhibitor Protein residue retrieved Ritonavir SARS-CoV-2 SARS-CoV-2 main protease Spread target trajectory treat Virtual screening virus with COVID-19 [DOI] 10.1016/j.imu.2021.100516 [Article Type] Research article
Contradictions in the promotion of publishing academic and scientific journal articles, and the inability to cope with the new coronavirus (COVID-19)Commentary Published on 2021-01-122022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] COVID-19, [키워드] accelerate arise article articles Care contradiction coronavirus COVID-19 global public health Health Infectious disease Journal article knowledge New coronavirus NIH outbreak pathogen provided public health Publishing quartile question Research Research Ethics Research policy response translational [DOI] 10.1186/s13756-021-00884-0 PMC 바로가기 [Article Type] Commentary
Deep Learning applications for COVID-19Survey Paper Published on 2021-01-112022-10-30 Journal: Journal of Big Data [Category] COVID-19, [키워드] accelerate Answering computer computer vision COVID-19 COVID-19 pandemic COVID-19 research deep Deep Learning applications detection drug Epidemiology example Forecasting generalization help Image include intelligence interpretability language learning life Life Sciences limitation Limited literature review misinformation natural natural language processing prediction privacy processing provide Public repurposing Research Retrieval robotics Structure vision [DOI] 10.1186/s40537-020-00392-9 PMC 바로가기 [Article Type] Survey Paper
Option-based guarantees to accelerate urgent, high-risk vaccines: a new market-shaping approachOpinion Article Published on 2021-01-112022-10-31 Journal: F1000Research [Category] COVID-19, MERS, [키워드] accelerate Advance market commitments approach approaches COVID-19 vaccine Critical effective Financing mechanisms Government health economics Perspective proportion public policy reduce risk Safe turn Vaccine vaccine for COVID-19 Vaccines while [DOI] 10.12688/f1000research.26482.2 PMC 바로가기 [Article Type] Opinion Article
Viroinformatics-Based Analysis of SARS-CoV-2 Core Proteins for Potential Therapeutic TargetsArticle Published on 2021-01-112022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] accelerate acute respiratory syndrome analyzed antiviral drug approach assessments blood oxygen level candidate drug computational approach conserved core coronavirus COVID-19/SARS-CoV-2/coronavirus 2 decrease domain drug drug candidate drug candidates Drug discovery effective hemoglobin hypoxia in silico lower respiratory tract diseases mechanism molecular target multidimensional Multiple sequence alignment Novel coronavirus Orthocoronavirinae performed Potential Protein Proteins provided RdRP RdRp protein RNA-dependent RNA polymerase SARS-CoV-2 sequence specific antibodies Spike protein target the Spike therapeutic Treatment virus virus infection [DOI] 10.3390/antib10010003 PMC 바로가기 [Article Type] Article
Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses Research Published on 2021-01-112022-10-05 Journal: Molecular Psychiatry [Category] 신약개발, [키워드] accelerate Activation adjusted Analysis approach BDNF candidate drug candidate drugs comorbid conditions CYP2D6 disorder Drug repurposing Electronic health record FIVE functional G-protein HTR1B mechanism mechanism of action medication Mortality OPRD1 OPRK1 OPRM1 Pathways Patient patients POMC public health crisis receptors Serotonin Signaling SLC6A4 Substance use disorder treat urgency [DOI] 10.1038/s41380-020-01011-y [Article Type] Research
Key points of technical review for the registration of SARS-CoV-2 antigen/antibody testsSARS-CoV-2 항원/항체 검사 등록을 위한 기술검토 요점Regulatory Published on 2021-01-112022-09-01 Journal: Bioanalysis [Category] 임상, 진단, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antigen approval caused center Clarification coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Device Evolution expand facilitate initiated NMPA outbreak pandemic Point Registration respiratory review SARS-CoV-2 SARS-CoV-2 antigen Spread Test tests worldwide pandemic [DOI] 10.4155/bio-2020-0219 PMC 바로가기 [Article Type] Regulatory