Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE‐2 expression in the respiratory system of pigletsOriginal Research Published on 2020-12-272022-10-31 Journal: Food Science & Nutrition [Category] COVID-19, [키워드] accompanied ACE ACE inhibitor addition allergies allergy alleviate alternative antibiotic angiotensin‐converting enzyme 2 antibiotic Antibiotics decrease develop enzyme expression Extract feed additive Granule growth Immunoglobulin immunoglobulin A incidence inhibiting inhibitor intestinal lower expression lung tissue mechanism of action Piglets Pneumonia PROTECT reduce expression reducing reported respiratory symptom Respiratory system risk Schematic selected serum immunoglobulin level Side effect significantly significantly lower tracheal Treatment weaning [DOI] 10.1002/fsn3.2089 PMC 바로가기 [Article Type] Original Research
Anxiety and Sleep Disturbances Among Health Care Workers During the COVID-19 Pandemic in India: Cross-Sectional Online SurveyOriginal Paper Published on 2020-12-222022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, [키워드] Affect age alleviate Analysis Anxiety Care caused Community conditions conducted COVID-19 COVID-19 pandemic cross-sectional determine disturbance Effect evaluate evaluated Facebook Factor female female gender GAD-7 Generalized Health care worker health care workers help implementation India Infection majority male measure mental health, personal protective equipment Mild moderate objective occupational epidemiology online survey pandemic participant Personal protective equipment platform Psychological psychological Impact Quality questionnaire reduce response Result risk SARS-CoV-2 scale significant level significantly Sleep Sleep disturbance sleep quality survey Symptom was collected WhatsApp worker [DOI] 10.2196/24206 PMC 바로가기 [Article Type] Original Paper
COVID-19 as ‘Game Changer’ for the Physical Activity and Mental Well-Being of Augmented Reality Game Players During the Pandemic: Mixed Methods Survey StudyOriginal Paper Published on 2020-12-222022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] activity addition affected age alleviate augmented reality games average change collected conducted connection COVID-19 COVID-19 pandemic demographics distress emotional game Gender Harry Harry Potter: Wizards Unite IMPROVE index Intervention Isolation lockdown maintain male Mental mental health mental health conditions objective pandemic participant physical physical activity Pokémon GO Pokémon poor mental health Population predictor promote qualitative data Quantitative data REALITY recruited reduced reported Research Result seeking shown significant increase significantly Social distancing measure Stress survey sustained Well-being [DOI] 10.2196/25117 PMC 바로가기 [Article Type] Original Paper
Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip SystemFull Paper Published on 2020-12-212022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] accelerate activated acute respiratory syndrome alleviate alveolar alveolar epithelium Analysis cause caused cell types circulating coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 disease Disease model Drug testing Endothelium exacerbated exhibit feature global pandemic Human human disease Immune cell immune cell recruitment immune response in vitro Infection Inflammation Inflammatory cytokine inhibit Injury innate immune response involved Lung injury Model organ organ chip pathway platform provide Remdesivir Research response SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 susceptibility System unique viral infection viral replication virus [DOI] 10.1002/advs.202002928 PMC 바로가기 [Article Type] Full Paper
COVID-19 Symptom-Related Google Searches and Local COVID-19 Incidence in Spain: Correlational StudyOriginal Paper Published on 2020-12-182022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] alleviate approach Behavioral epidemiology big data Care center complementary correlation COVID-19 COVID-19 case COVID-19 pandemic Critical dependent on disease Evolution Forecast Google H1N1 influenza Health help incidence of COVID-19 individual infodemiology infosurveillance linear nowcasting objective offer outbreak pandemic Pandemics plague population level predict predicted provided public health real time reported Result smart data Spain statistical the epidemic time lag tracking trend [DOI] 10.2196/23518 PMC 바로가기 [Article Type] Original Paper
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion콜레스테롤 25-수산화효소는 막 융합을 차단하여 SARS-CoV-2 복제를 억제합니다530 Published on 2020-12-152022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alleviate Antiviral antiviral activities antiviral activity antiviral response approach blockade catalyzed caused CH25H chimeric cholesterol Clinical treatment coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 deaths drug Drug administration effective effective vaccine Effective vaccines etiological agent food germline help highlight identify inhibit SARS-CoV-2 inhibitors of SARS-CoV-2 Innate immunity interferon late endosome late endosomes mechanism membrane fusion molecular basis pathogenicity produced Replication respiratory restrict Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 spike protein Significance Spike protein stomatitis supportive therapies supportive therapy suppresse Symptoms tested therapeutic Vaccine vesicular stomatitis vesicular stomatitis virus virus entry viruses [DOI] 10.1073/pnas.2012197117 PMC 바로가기 [Article Type] 530
Home-Based Care for People with Alzheimer’s Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to SolutionsCommentary Published on 2020-12-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] ADRD Adults affecting alleviate Alzheimer’s disease Care challenge COVID-19 Dementia Evidence health condition home-based care lack likelihood majority Measures novel coronavirus disease Older pandemic Policy Psychological resulting Risk factors solution subject susceptible virus while [DOI] 10.3390/ijerph17249303 PMC 바로가기 [Article Type] Commentary
The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular SystemCardiovascular Medicine Published on 2020-12-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome alleviate appear ARDS attenuate Cardiac arrhythmia cardiovascular cardiovascular complications cardiovascular system cause caused Cell clinical study Complication coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 positive patient CXCL10 Cytokine storm deaths develop drug Effect elevated global pandemic hallmark heart help IL-2 IL-22 IL-6 IL-7 immune system immunomodulatory Immunosuppression induced infected case Infection lung Mesenchymal stem cells Mortality MSC MSCs myocardial injury myocarditis organ systems Patient Prevent primary site pro-inflammatory cytokine regeneration and repair role SARS-CoV-2 Severe case shown storm stromal cell suggested syndrome System the cytokine storm therapy Thromboembolism tissue repair TNFα [DOI] 10.3389/fcvm.2020.602183 PMC 바로가기 [Article Type] Cardiovascular Medicine
Blockchain-Based Solution for COVID-19 Digital Medical Passports and Immunity CertificatesComputers and Information Processing Published on 2020-12-082022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] alleviate Analysis Blockchain caused contagious contribute COVID-19 deaths Digital digital medical passports disease effective response Ethereum events help identify identity Immunity Immunity certificate immunity certificates Infection information maintain mitigate pandemic Passport presenting reduce security Smart contracts solution Spread tested the disease traceability tracking [DOI] 10.1109/ACCESS.2020.3043350 PMC 바로가기 [Article Type] Computers and Information Processing
A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol침습성 COVID-19 및 기계 환기로 치료된 급성 호흡 부전 환자에서 CONvalescent 혈장 요법의 효능을 평가하기 위한 다기관 무작위 시험: CONFIDENT 시험 프로토콜Study Protocol Published on 2020-12-072022-09-01 Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] Acute respiratory failure alleviate Analysis approach approval Belgium Blinding board center collected Consent convalescent plasma COVID-19 COVID-19 pandemic data safety monitoring board diagnosed DSMB Efficacy Endpoint Europe Evidence evidence of Evolution of SARS-CoV-2 expected expected mortality frailty funding Health care homogeneous hospital Hospitalized Hypothesis immunization include Inclusion intensive care unit Intention intention to treat Interim Interim analyses International Intervention less mechanical ventilation mechanically ventilated patients monitoring board Mortality multicenter National Neutralizing antibodies neutralizing antibody passive immunization Patient patients patients treated peer-reviewed plasma Pneumonia randomization Randomized randomized trial reached reduce mortality reduction Registered Registration registration number Respiratory failure review risk SARS-CoV-2 SARS-CoV-2 pneumonia severe respiratory failure specific neutralizing antibodies specific neutralizing antibody Standard of care Stratification Symptom the patient therapy TRAIL treated Treatment Trial trial protocol university university hospital [DOI] 10.1186/s12890-020-01361-x PMC 바로가기 [Article Type] Study Protocol