Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels
Alpha1-항트립신 혈청 수준이 있는 SERPINA 유전자 클러스터의 변이체의 인과적 및 합성적 연관성
Research Article
[키워드] accelerated
allele
Alpha1-antitrypsin
Analysis
antitrypsin
association
Author
Blood
Causal
chromosomal locus
chronic obstructive
chronic obstructive pulmonary disease
circulating
city
Cohort
common variants
complex
Concentration
contribute
COPD
deficiency
defined
Degradation
determined
driven by
Effect
emphysema
enzyme
examined
example
explained
functional
gene cluster
General population
Genetic
genetic determinant
genetic determinants
Genetic polymorphism
genetic polymorphisms
Genetic variant
Genome-wide association study
genome-wide significance
genotyped
genotyping
GWAS
Health
heart
hidden
independent
individual
inhibitor
Level
locus
Lung function
MAF
MAFs
Meta-analysis
minor allele frequency
nucleotide
obstructive pulmonary disease
participant
phenotype
PI
polymorphism
PROTECT
Protein
pulmonary disease
pulmonary tissue
reached
reduce
replicated
Replication
respiratory
risk
risk factor
SERPINA1
SERPINA1 gene
Serum level
serum levels
Single nucleotide polymorphism
single nucleotide polymorphisms
Smokers
SNP
SNPs
subsequent
suggested
Support
synthetic
tissue
transfer
Variability
variant
variants
while
[DOI] 10.1371/journal.pgen.1003585 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003585 PMC 바로가기 [Article Type] Research Article