Failure of malaria chemoprophylaxis with mefloquine in an oversize traveller to Mozambique모잠비크로의 대형 여행자에서 메플로퀸을 이용한 말라리아 화학 예방 실패Case Report Published on 2013-12-182024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Chemoprophylaxis failure malaria mefloquine [DOI] 10.1186/1475-2875-12-451 PMC 바로가기 [Article Type] Case Report
Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8 , as a Genetic Component of Neural Tube Defects in Humans개의 게놈 전반에 걸친 연관 매핑을 통해 인간의 신경관 결함의 유전적 구성 요소인 호메오박스 유전자 NKX2-8 식별 가능Research Article Published on 2013-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected Analysis animal animal models Author birth defects Brain canine Care caused Central nervous system chromosome closure codon Combination comparable complex component condition contribute costly defect develop disease dog during pregnancy dysraphism embryonic ENCODE environmental factors etiology Evidence ExoN exons expected explain expressed failure found frameshift frameshift mutation general term Genes Genetic Genetic studies genetics Genome genome-wide association genomic region home environment Homeobox Human human population human populations humans identification identify in addition to interactions lead malformation mapped mapping mechanism Medical care molecular basis morbidity and mortality multifactorial Mutation Neural neural tube Neural tube defect Neural tube defects NKX2 NKX2-8 NTD NTDs occur pathology Patient performed predicted Pregnancy premature stop codon Protein rare variant Rare variants receive Regulatory regulatory gene reported resulting secondary to sequenced Sequencing significantly skin Soft tissue spina bifida spinal cord spinal dysraphism Structure Taking tissue tissues tube vertebral column Weimaraner [DOI] 10.1371/journal.pgen.1003646 PMC 바로가기 [Article Type] Research Article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegansTetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다Research Article Published on 2012-09-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light [DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article
Plasmodium vivax Malaria Relapses after Primaquine Prophylaxis프라임퀸 예방요법 후 플라스모디움 비박스 말라리아 재발Letter to the Editor Published on 2006-11-012024-08-26 Journal: Emerging Infectious Diseases [Category] 말라리아, [키워드] failure letter Plasmodium vivax primaquine Relapse resistance [DOI] 10.3201/eid1211.060613 PMC 바로가기 [Article Type] Letter to the Editor