The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomesReview Article Published on 2021-01-262022-10-04 Journal: Mucosal Immunology [Category] 바이오마커, [키워드] acute infections affected aggravate alteration Arm change colonize coronavirus disease Critical Defense disease disorder Effect functions Gut gut microbiota Health human gastrointestinal tract Immunity lung mechanism microbial outcome outcomes potential mechanism Secondary bacterial infections severity the disease viral respiratory viral respiratory infection viral respiratory infections [DOI] 10.1038/s41385-020-00361-8 PMC 바로가기 [Article Type] Review Article
The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR ProteinsReview Published on 2021-01-222022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Activation addition bind Cancer caspase CIITA complex conserved contributing to differential expression domain Ebola expression functions Gene Expression Gene regulation homolog Immunity inhibitor intrinsic mammalian master regulator MHC MHC class MHC class II MHC genes MHC-I MHC-II NLR NLRC5 NLRP3 Protein Protein–protein interaction Proteins recruitment regulated Regulation the major histocompatibility transcriptional regulation transcriptional regulator virus replication [DOI] 10.3390/ijms22031074 PMC 바로가기 [Article Type] Review
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages기관지폐포 세척액의 선천적 및 적응 면역 단일 세포 프로파일링을 통해 심각한 COVID-19와 경증 구별Article Published on 2021-01-212022-09-12 Journal: Cell Research [Category] 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] adaptive Alveolar macrophages Anti-inflammatory BAL bioinformatics Bronchoalveolar lavage build CD4 CD8 Cell change Characteristics characterized clearance contribute COVID-19 Critical Evidence expressing fibrosis functions Gene Expression Genome-wide analysis of gene expression host immune system Hyperinflammatory immune immunopathology in viral Innate immunity involved lung Lung epithelial cells Macrophage marker Mild monocyte naïve neutrophil Non-COVID-19 Patient Pneumonia proportion reveal single-cell Stress T-cell Trajectories trajectory undergo vice [DOI] 10.1038/s41422-020-00455-9 PMC 바로가기 [Article Type] Article
Advanced echocardiographic phenotyping of critically ill patients with coronavirus-19 sepsis: a prospective cohort studyResearch Published on 2021-01-202022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] Afterload alteration Biomarker cardiac cardiac dysfunction changes characterized clinical impact clinical implications clinical setting Cluster Concentration condition correlated COVID-19 COVID-19 patient COVID-19 sepsis Critically ill Critically ill patient echocardiographic echocardiographic parameter feasibility functions hemodynamic hierarchical clustering homogeneous incidence Interaction males management median age Mortality multivariable analysis myocardial injury parameter Patient physiological positively correlated prospective cohort study recorded Result Sepsis septic patients serum supplementary material therapeutic variable were assessed were measured [DOI] 10.1186/s40560-020-00516-6 PMC 바로가기 [Article Type] Research
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19SARS-CoV-2 수용체 ACE2 활성 수준은 대동맥 협착증이 있는 고령 환자에서 매우 높아집니다. COVID-19의 중증도에 대한 바이오마커로서의 ACE2의 의미Original Article Published on 2021-01-202022-09-11 Journal: GeroScience [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Aortic stenosis Biomarker blood pressure cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular diseases cellular receptor chronic inflammation circulating Clinical data coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 COVID-19 mortality COVID-19 susceptibility CRP drug Ejection fraction elderly Elderly patient elderly patients elevated flow velocity functions GFR healthy individual healthy individuals high mortality higher risk hypertension hypertensive implication independent independent of inflammatory state inhibitor inhibitory Kidney function left ventricular ejection fraction Level no effect Older Patient patients RAAS receptor ACE2 respiratory SARS-CoV-2 SARS-CoV-2 susceptibility serum severe acute respiratory syndrome Coronavirus severity of COVID-19 Support systolic pressure TAPSE the SARS-CoV-2 ventricular ventricular ejection were measured [DOI] 10.1007/s11357-020-00300-2 PMC 바로가기 [Article Type] Original Article
Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19Bioengineering and Biotechnology Published on 2021-01-152022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] activated acute respiratory distress Alpha Alter Analysis ARDS Betacoronavirus candidate caused cellular processes conserved COVID-19 COVID-19 cytokine storm cytokine Cytokine storm Cytokines disease DNA damage FIVE functions Gene Expression Genes Genetic humans identify in vitro in vivo infect inflammatory immune response lncRNA Long marker markers MERS-CoV new strain non-coding RNA NorAD outbreak overexpressed Regulation regulatory element RNA SARS-CoV SARS-CoV-2 storm syndrome targets the disease virus Wuhan, China [DOI] 10.3389/fbioe.2020.582953 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study퀘르세틴, 코로나19 유발 급성 신장 손상 치료제로서의 가능성: 네트워크 약리학 및 분자 도킹 연구 기반Research Article Published on 2021-01-142022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] 3CL ACE2 Activation active site active sites acute kidney Acute kidney injury AKI apoptosis-related signaling pathway apoptosis-related signaling pathways binding blockade Cell Chronic kidney disease CKD clinical setting contribute Critical develop effective function functions high mortality Infection Inflammatory inhibition inhibitor Injury Interaction investigated kidney Kidney disease kidneys life cycle mechanism molecular docking network pharmacology patients with SARS-CoV-2 Potential treatment protease PROTECT protective effect Protein quercetin renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease signaling pathways specific treatment target targets therapeutic therapeutic agent transition Viral viral life cycle [DOI] 10.1371/journal.pone.0245209 PMC 바로가기 [Article Type] Research Article
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022SARS-CoV-2-특이적 단일클론항체 CR3022의 치료 가능성을 조정하기 위한 해부 전략Research Article Published on 2021-01-112022-09-10 Journal: JCI Insight [Category] 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antibody Antigen coronavirus COVID-19 CR3022 Critical effort Epidemiology function functional functions globe hamsters highlighting IgG1 immune clearance immunology infected cell infected cells Infection Interaction lack mice monoclonal antibody mutations pathology respiratory SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spread susceptible therapeutic potential Therapeutics Treatment variant variants Viral viral replication virus weight loss [DOI] 10.1172/jci.insight.143129 PMC 바로가기 [Article Type] Research Article
OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and moreAcademicSubjects/SCI00010 Published on 2021-01-082022-10-31 Journal: Nucleic Acids Research [Category] Coronavirus, MERS, [키워드] annotations conserved coronavirus COVID-19 pandemic database domain evolutionary relationship feature functional functions Genes Genome improvement information isoform isoforms Local Nidovirale orthologs Other Phylogenetic Primers provide resource SARS-CoV-2 virus website [DOI] 10.1093/nar/gkaa1007 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Novel modulators of p53-signaling encoded by unknown genes of emerging virusesResearch Article Published on 2021-01-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] approach binding Cancer Cell de novo DNA Ebola experiment function functional functions genomic Hypothesis hypothetical identify infections Influenza Interaction interfere long non-coding RNA mechanism molecular New non-coding RNA novel Open reading frame p53 predicted Protein resource RNA viruses RNAs Signaling Systems biology tested transcription factor viral nucleic acid Viral protein Viral proteins virus viruses Zika Zika virus ZIKV [DOI] 10.1371/journal.ppat.1009033 PMC 바로가기 [Article Type] Research Article