A Rapid and Sensitive Microfluidics-Based Tool for Seroprevalence Immunity Assessment of COVID-19 and Vaccination-Induced Humoral Antibody Response at the Point of Care현장 진료에서 COVID-19 및 예방 접종 유도 체액 항체 반응의 혈청유병 면역 평가를 위한 신속하고 민감한 미세유체 기반 도구Article Published on 2022-08-102022-09-11 Journal: Biosensors [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approved assessment booster causative agent circulating clinical decision clinical decision support tool clinician conditions convalescent plasma COVID-19 cross-reactive antibody death diagnostic diagnostics disease severity donors ecosystem Health help Hospitalization humoral Humoral immunity immunization immunized immunocompromised individual individuals induce infected individual Infection Microfluidics multiple dose multiple doses optimization Patient platform POC POC test Point point of care point-of-care predict proof proof of concept protein-based vaccine Protein-based vaccines Quantitative Rapid reducing researcher response risk robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-specific IgG sensitive Seroconversion Serological assay Seroprevalence Support the disease the timing vaccination Viral viral variant while [DOI] 10.3390/bios12080621 PMC 바로가기 [Article Type] Article
Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studiesCOVID-19 위험에 대한 감수성 증가에 기여하는 요인 식별: 멘델식 무작위 배정 연구의 체계적인 검토Article Published on 2022-08-102022-09-11 Journal: International Journal of Epidemiology [Category] 유전자 메커니즘, [키워드] ABO analyses Anthropometrics association assumption attributes Biomarkers Bipolar disorder cardiometabolic disease cardiometabolic diseases Chronic kidney disease contributing to coronavirus disease Coronavirus disease 2019 COVID-19 deficit disease disorder drug English evaluated Evidence Factor Factors fibrosis Genetic help higher risk Hospitalization hyperactivity identify identifying Idiopathic pulmonary fibrosis IL-6 inception Increases increases in Inflammatory factor inflammatory factors interleukin Intervention ischaemic stroke Kidney disease mendelian randomization Mendelian randomization studies Mendelian randomization study OAS1 obesity outcome predicted predisposition protein expression proteomic pulmonary fibrosis risk Schizophrenia searched selected severity smoking socio-demographic suggested susceptibility systematic review target targets treating COVID-19 Vitamin D [DOI] 10.1093/ije/dyac076 PMC 바로가기 [Article Type] Article
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC studyResearch article Published on 2022-08-092022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 치료기술, [키워드] 7-point ordinal scale 95% CI age antibody assessment association baseline Better characteristics of patient chest imaging Cohort Comorbidities coronavirus disease COVID-19 creatinine death demographics discharge disease course disease severity Dyspnea elevated Factor female finding Follow-up funding Hispanic ethnicity hospital Hospitalization Hospitalized hospitalized COVID-19 Immunophenotyping IMPROVE integration interquartile range Invasive mechanical ventilation Laboratory Logistic regression longitudinal lowest lymphopenia management median age NIH Odds ratio offer outcome overall mortality PASC Patient PCR cycle provide Radiographic required Respiratory illness Result risk factor SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 PCR SARS-CoV2 serology severity Sex survivor Symptom Symptomatic patients The United States threshold Trajectories trajectory Unsupervised clustering Viral load was performed [DOI] 10.1016/j.ebiom.2022.104208 [Article Type] Research article
Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study항바이러스제를 광범위하게 사용하면 COVID-19 전염병을 억제할 수 있습니까? 모델링 연구Article Published on 2022-08-092022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 치료제, [키워드] age agent agent-based model analyzed Antiviral antiviral drug antiviral drugs Antiviral effect antiviral effects Antiviral treatment antiviral treatments Belgium Combination country COVID-19 COVID-19 disease COVID-19 hospitalization death deaths disease effective Effective vaccines help highlight Hospitalization inception Increases Infection Kenya location majority mathematical mathematical model mitigate Mortality Older populations Prevent prevented progression reduce reduced reducing Safe SARS-CoV-2 SARS-CoV-2 transmission shown significantly symptomatic symptomatic infection symptoms onset synergistic synergistic effect Transmission Treatment treatment initiation treatments for COVID-19 United State United States vaccination vaccination rate widespread [DOI] 10.1186/s12879-022-07639-1 PMC 바로가기 [Article Type] Article
Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COVID-19 vaccinated individuals and its associated factors: A systematic review and meta-analysis protocol코로나19 백신 접종자의 SARS-CoV-2 감염, 입원 및 치사율의 세계적 부담 및 관련 요인: 체계적인 검토 및 메타 분석 프로토콜Article Published on 2022-08-092022-09-11 Journal: PLoS ONE [Category] meta-analysis, SARS, [키워드] Analysis association Case fatality rate case fatality rates CENTRAL CINAHL Complete contribute Controlled controlled trials COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines determine disease severity dose eligible estimate estimation Excerpta Medica database Factor Fatality rate finding help Hospitalization index individual information investigated literature material Meta-analysis morbidity morbidity and mortality Nursing performed Prevalence protocol public health random effect model Reinfection SARS-COV-2 infection Science Direct severity subgroup analysis systematic review the disease used to calculate vaccinated individual vaccinated individuals Vaccine vaccine dose vaccine doses [DOI] 10.1371/journal.pone.0272839 PMC 바로가기 [Article Type] Article
T cell perturbations persist for at least 6 months following hospitalization for COVID-19T 세포 교란은 COVID-19로 입원한 후 최소 6개월 동안 지속됩니다.Article Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] addition affected alteration anti-Nucleocapsid IgG antibody Arm CD4 CD57 CD69 CD8 Cell consequence convalescence COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients dependent on elevated event expressing flow cytometry follicular Hospitalization Humoral response humoral responses IgG immune immune cells immune system Immunity Inclusion marker Neutralizing Neutralizing antibodies neutralizing antibody responses Pathogenesis Perturbation Population populations SARS-CoV-2 spectral flow cytometry. study duration sustained symptom onset T cell T cell activation T cell impairment T cell responses T cell subsets T cells T helper TEMRA the disease upregulated with COVID-19 [DOI] 10.3389/fimmu.2022.931039 PMC 바로가기 [Article Type] Article
Quantitative chest computed tomography combined with plasma cytokines predict outcomes in COVID-19 patientsResearch article Published on 2022-08-062022-10-05 Journal: Heliyon [Category] 바이오마커, 유전자 메커니즘, 진단, [키워드] Admission age approach AUC Biomarker Chest computed tomography Chest CT collected Combination COVID-19 COVID-19 patient COVID-19 patients Critical cytokine Cytokines death effort FIVE GGO ground-glass opacity help high risk Hospitalization IL-6 IL-8 International Laboratory lung mechanism Metrics MONITOR Mount Sinai New York outcome outcomes Patient physician plasma Plasma cytokine predict Predictive predictive power predictor Quantitative radiology recent SARS-CoV-2 SARS-CoV-2 infections scoring system severity Spread System TNF-α variables [DOI] 10.1016/j.heliyon.2022.e10166 [Article Type] Research article
Analysis of potential risk factors associated with COVID-19 and hospitalizationObservational Study Published on 2022-08-052022-10-05 Journal: Frontiers in Public Health [Category] SARS, 임상, [키워드] addition adjusted administration age Analysis analyzed association Care carried clearance Clinical characteristics comorbid patient Comorbidities Comorbidity Complication complications conducted Coronavirus disease 2019 COVID-19 COVID-19 pandemic cross-sectional database determine Factor Fever Gender group help hospital Hospitalization hypertension ICU admission ICU Patients indicated intensive care majority male medication medications non-ICU obesity Odds ratio outcome Patient patients hospitalized patients older Pneumonia potential risk predictor Prednisolone reduce Remdesivir retrieved retrospective risk factor Risk factors significantly statistically suggested Symptoms syndrome type 2 diabete understanding with COVID-19 [DOI] 10.3389/fpubh.2022.921953 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 and Plasmodium falciparum Co-Infection in a Returning Traveler돌아오는 여행자의 SARS-CoV-2 및 Plasmodium falciparum 공동 감염Article Published on 2022-08-052022-09-11 Journal: Frontiers in Public Health [Category] SARS, 말라리아, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Anxiety Arbidol China Co-infection Compound coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Diagnosis diazepam dihydroartemisinin discharge discharged Diseases Evidence evidence of health system Healthcare system Hospitalization hydrochloride inflammatory reactions Insomnia interferon Lopinavir LOPINAVIR AND RITONAVIR malaria Mental no evidence of offer P. falciparum pandemic Paroxetine Paroxetine Hydrochloride Piperaquine Plasmodium Plasmodium falciparum raise reported Ritonavir SARS-CoV-2 severe acute respiratory syndrome Coronavirus sub-Saharan Africa Tablet tablets Tartrate tested the patient thymosin Treatment vital sign zolpidem Zolpidem Tartrate [DOI] 10.3389/fpubh.2022.871374 PMC 바로가기 [Article Type] Article