Descriptive epidemiology of the first wave of COVID-19 in Petaling District, Malaysia: Focus on asymptomatic transmission말레이시아 페탈링구 코로나19 1차 유행병 기술역학: 무증상 전파를 중심으로Covid-19 Published on 2021-04-212022-09-10 Journal: Western Pacific Surveillance and Response Journal [Category] MERS, SARS, 치료기술, [키워드] analysed Asymptomatic Asymptomatic case Asymptomatic cases Characteristics close contact Cluster common Comorbidities Comorbidity conducted confirmed cases contact with cough COVID-19 COVID-19 case COVID-19 cases COVID-19 outbreak date of onset death Descriptive analyses Descriptive analysis Descriptive epidemiology District epidemiological link Epidemiology Face masks Fever First wave focus forms had no hand hygiene Health health facilities health office hygiene incidence rate infections laboratory-confirmed Local local infections Malaysia Multiple occurred office remained reported Research Result social distancing sore throat Symptom symptomatic Symptoms the disease Transmission transmission of SARS-CoV-2 transmitted Travel were recorded [DOI] 10.5365/wpsar.2020.11.4.001 PMC 바로가기 [Article Type] Covid-19
SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)영국에서 항체 음성 의료 종사자와 비교한 항체 양성 환자의 SARS-CoV-2 감염률: 대규모, 다기관, 전향적 코호트 연구(SIREN)Multicenter Study Published on 2021-04-172022-09-11 Journal: Lancet (London, England) [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI adjusted Analysis antibody Antibody test antibody test) Antibody testing assigned baseline clinically Cohort cohorts COVID-19 defined Department determined by effective eligible England enrolled enrolment Evidence first positive Follow-up frailty future infection had no hazard health-care hierarchy hospital Immunity incidence incidence density incidence rate include Increased individual individuals induce Infection infection rate infection rates infection with SARS-CoV-2 infections Linked data lower risk median median interval multicentre participant Participants PCR PCR positive PCR test PCR testing PCR tests PCR-confirmed Poisson distribution positive positive PCR positive PCR test Potential Primary infection Primary outcome prospective cohort study protective effect Public Health England questionnaire Questionnaires rate ratios recruited Region Reinfection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Scottish Seroconversion Support Symptom symptomatic and asymptomatic UK Government was done was used were excluded [DOI] 10.1016/S0140-6736(21)00675-9 PMC 바로가기 [Article Type] Multicenter Study
A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trialSARS-CoV-2 백신(비활성화, Vero 세포)의 효능과 안전성을 평가하기 위한 무작위 이중 맹검 위약 대조 임상 3상 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-132022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, 임상, 치료기술, [키워드] 1:1 24 hour 24 hours 95% confidence interval Activation Active surveillance administration Administrative Personnel Adverse adverse event adverse events Adverse reaction Adverse reactions African green monkey age Algorithm Aluminium aluminium hydroxide anaphylaxis Antibody test Antibody titer Antigen Arm asplenia assigned assumed assumption Autoimmune baseline bleeding disorders Blinding blood product blood products blood sample Blood samples breastfeeding women breath carried Cell culture China chloride Clinical efficacy clinical trial code Cohort cohorts comparator consent form cooperation Corticosteroid Corticosteroids COVID-19 COVID-19 cases COVID-19 disease COVID-19 symptoms COVID-19 test criteria Critical CRO Data and Safety Monitoring Board Day development diary dihydrogen DIHYDROGEN PHOSPHATE disease disodium disodium hydrogen phosphate dissemination dose dose of vaccination double blind double-blind double-blind study Efficacy Efficacy and safety element eligible Endpoint enrolled enrolment ethics committee evaluate event excluded exclusion criteria expected Follow-up follow-up period Frequency Gender genders green monkey group groups healthcare Healthcare professional healthcare professionals higher risk HIV infection hospital Hospitalization hydrogen Hydrogen phosphate hydroxide hypersensitivity identity IgG level IgG levels IgG test immunogenicity Immunoglobulin immunoglobulins immunosuppressive immunosuppressive therapy inactivated Inactivated Vaccines incidence incidence rate include Inclusion individual information informed consent form initiated Interactive Web Response System intramuscular dose investigator IWRS IWRS system kidney knowledge Local local reactions management medical doctors medical emergency Ministry of Health mortality rates neutralizing antibody Neutralizing antibody titer Novel coronavirus number Nurses objective Omega Other participant PCR PCR positivity performed Phase III Clinical Trial phosphate Placebo placebo group placebo-controlled positive pregnancy test pregnant preparation primary efficacy endpoint professional proportion protocol randomised randomised controlled trial randomised placebo controlled trial randomization Randomized Randomly Reactions receive recorded regimens Registration reported response risk risk of infection RT-PCR RT-PCR test RT-PCR tests Safety Monitoring Board Sample size SARS-CoV-2 vaccine SARS-CoV-2 virus screened second dose secondary Secondary objectives Serious Adverse Event Serious Adverse Events seroconversion rate Seropositivity severity severity of COVID-19 shown Sinovac sodium Sodium chloride sodium dihydrogen phosphate Sponsor status study group Study protocol subject subject’ supplementary material Symptom symptomatic symptomatic case symptomatic cases System systemic adverse reaction the ethics committee the timing the vaccine therapy Treatment treatment arm Trial Turkey two-sided vaccinated groups vaccination Vaccine Vero Vero Cell Web website width with COVID-19 within 6 months [DOI] 10.1186/s13063-021-05180-1 PMC 바로가기 [Article Type] Letter
The Impact of Temperature on the Risk of COVID-19: A Multinational StudyArticle Published on 2021-04-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] 95% CI acute respiratory syndrome adjusted affecting age ambient analyzed average coronavirus country Coverage death determinant disease Diseases elder Epidemic Factor Factors Health help high accuracy highlight Impact incidence rate International international tourism Measures mortality risk outbreak Population random randomly divided risk risk factor ROC SARS-CoV-2 statistical model temperature the SARS-CoV-2 Universal health coverage [DOI] 10.3390/ijerph18084052 PMC 바로가기 [Article Type] Article
Spatio-temporal evolution and influencing mechanism of the COVID-19 epidemic in Shandong province, ChinaArticle Published on 2021-04-092022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] affected affecting age and gender Analysis change Characteristics China Chinese Cluster collected confirmed case COVID-19 COVID-19 epidemic Culture demographic characteristics diffusion Diseases distribution Epidemic Evolution External geographical location Health Health care incidence incidence rate information Intervention majority mathematical measure Measures mechanism Migration Novel coronavirus outbreak Perspective Pneumonia public health crisis Region reported spread of COVID-19 the epidemic Wuhan [DOI] 10.1038/s41598-021-86188-0 PMC 바로가기 [Article Type] Article
Assessment of Pediatric Admissions for Kawasaki Disease or Infectious Disease During the COVID-19 State of Emergency in JapanResearch Published on 2021-04-062022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted Admission age age and sex analyzed assessment conducted Contact COVID-19 COVID-19 pandemic cross-sectional decrease disease Diseases droplet transmission Emergency Epidemic experiment exposure finding Gastrointestinal infection hospital Hospital admission hospitals Importance incidence incidence rate Infection infections Infectious disease Isolation Japan Kawasaki disease measure median multicenter objective participant Patient patients Pediatric patient Pediatric patients Point Poisson regression model primary end point quarantine Relevance respiratory tract respiratory tract infection Result SARS-CoV-2 setting significant decrease significantly increased state study participant suggested Transmission Trigger was used [DOI] 10.1001/jamanetworkopen.2021.4475 PMC 바로가기 [Article Type] Research
Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic SinArticle Published on 2021-04-012022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 229E acute respiratory syndrome ADE cellular clinical clinical severity score Combination convalescent plasma Coronaviridae Coronavirus-2 COVID-19 Evidence HKU1 Humoral immunity IgG Immunity in vitro in vivo incidence rate Infection Laboratory neutralizing antibody NL63 nucleocapsid protein OC43 original SARS CoV-2 SARS-CoV-2 seasonal Sin WHO World Health Organization’ [DOI] 10.3390/life11040298 PMC 바로가기 [Article Type] Article
Chemo-Preventive Effect of Vegetables and Fruits Consumption on the COVID-19 PandemicArticle Published on 2021-04-012022-10-30 Journal: Journal of nutrition & food sciences [Category] COVID-19, [키워드] acute respiratory syndrome addition Algorithm antiviral agent antiviral property approved boost caused Chemo preventive agents claimed collected Community Consumption contribute coronavirus Coronavirus disease 2019 COVID 19 COVID-19 COVID-19 incidence COVID-19 vaccine Critical death death rate deaths demonstrated disease drug Drug discovery Effect Efficacy Emergency use Evidence Factor Factors FDA food fruit fruits global pandemic Health Healthcare system help Hypothesis identify identifying immune system Immunity incidence rate Kaggle machine-learning Moderna morbidity and mortality mortality rate pathogen Pfizer Prevent reduce SARS-CoV-2 the SARS-CoV-2 the United State therapeutic vaccination vegetable vegetables PMC 바로가기 [Article Type] Article
Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across EuropeObservational Study Published on 2021-04-012022-10-05 Journal: The American journal of medicine [Category] SARS, 임상, [키워드] 95% confidence interval Acute cardiovascular admissions Acute coronary syndrome Acute heart failure acute respiratory syndrome Admission Admissions analyzed arrhythmia Cardiology changes in collected coronary syndrome coronavirus COVID-19 COVID-19 outbreak death Department Emergency Europe European evaluated Impact incidence rate multicenter Myocardial Odds ratio outbreak pandemic Patient provided risk risk of death SARS-CoV2 [DOI] 10.1016/j.amjmed.2020.08.043 PMC 바로가기 [Article Type] Observational Study
Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactionsSARS-CoV-2 돌연변이가 단백질 구조 및 바이러스 내 단백질-단백질 상호작용에 미치는 영향Article Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected analyzed binding affinity caused changes in Characteristics complexes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis docking Effect Frame globe Impact in some incidence incidence rate incidence rates Interaction interface investigated involved mutant Mutation nonsynonymous mutation Novel coronavirus nucleocapsid occurred Occurrence ORF3a ORF8 pandemic physiological Protein protein interactions protein sequence protein structure protein-protein interaction Q57H RMSD SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus Spread Structure structures the binding affinity the SARS-CoV-2 genome Treatment variance Viral protein virus genome [DOI] 10.1002/jmv.26597 PMC 바로가기 [Article Type] Article