Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes
폐렴구균 모자이크 유전자 내 베타-락탐 내성과 관련된 단일 뉴클레오티드 다형성의 포괄적인 식별
Research Article
[키워드] alterations
Amino acid
analysed
antibiotic
Antibiotic resistance
Antibiotic treatment
Antibiotics
approach
arise
association
Bacteria
Beta-lactam
beta-lactam antibiotics
block
blocks
carried
cause
change
children
clinical setting
collected
Comprehensive
description
determinant
determinants
Diseases
distribution
DNA fragment
explain
Frequency
Genetic
genetic association
genetic determinant
genetic determinants
Genome
Genome sequencing
Genome-wide association study
genomes
Haplotype
identification
identify
INDEL
indels
independent dataset
independent datasets
introduced
isolate
isolates
large sample
leads
lineages
loci
mechanism
Meningitis
morbidity
morbidity and mortality
more difficult
mosaic
Mutation
nasopharyngeal
non-susceptibility
nucleotide
organism
performed
pneumococcal
Pneumonia
pneumoniae
populations
predict
Previous studies
previous study
raise
Recombination
reported
resistance
responsible
sensitivity
sequence
single nucleotide
Single nucleotide polymorphism
single nucleotide polymorphisms
SNPs
Spread
strain
Strains
Streptococcus pneumoniae
susceptible
Traditional
Treatment
understanding
USA
variant
variants
while
[DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article