monocyte – Page 34 – Communicable Diseases Research

Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series

Research Article

Published on 2020-11-112022-10-30
Journal: mSphere [Category] COVID-19, SARS,

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

COVID-19 폐렴 환자에서 변경된 생체 에너지 및 단핵구의 미토콘드리아 기능 장애

Report

Published on 2020-11-052022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] aerobic aerobic glycolysis Affect Altered analyzed basal bioenergetics CCL2 cells chemokines classical monocytes COVID‐19 COVID‐19 CXCL10 Cytokines diminished expression Extracellular Glycolysis GM‐CSF high plasma levels IFN‐γ immature immunology Immunopathogenesis in vitro increased expression Inflammation Inflammatory cytokine Inflammatory cytokines inhibitors inhibitory inhibitory checkpoints Innate immunity investigation membrane membrane potential Microbiology, Virology & Host Pathogen Interaction Mitochondria mitochondrial mitochondrial dysfunction monocyte monocyte subsets Monocytes osteopontin oxidative burst OXPHOS Patient PD‐1 Peripheral blood peripheral blood monocytes plasma Pneumonia producing redistribution reduced respiratory capacity SARS‐CoV‐2 SARS‐CoV‐2 infection significantly subset these cell These cells TNF ultrastructure
[DOI] 10.15252/emmm.202013001 PMC 바로가기 [Article Type] Report

Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related Complications

Conference abstract

Published on 2020-11-042022-10-05
Journal: Blood [Category] 임상,

[키워드] Activation Acute kidney injury acute lung injury acute respiratory distress AKI allergic ARDS Autoimmune capillary leak syndrome caused clinical clinical status clinical study CLR Complication complications COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm Diseases disorders double-blind download downstream Efficacy and safety Endothelial cell equity evaluate evaluated Fc receptor figure fostamatinib Hospitalized hospitalized COVID-19 patients Hyperactivation immune complex immune system immune systems Immune thrombocytopenia immunomodulatory effect implicated improvement incidence inhibitor involved kidney kinase LPS lung master regulator metabolite monocyte mouse model Nadeem neutrophil other treatment pathogen pathway Patient patients patients treated phase placebo-controlled plasma Platelets Prevent prevention Progress Protective Randomized receptor reduced reference Result rheumatoid arthritis risk safety profile Signal transduction Standard of care SYK syndrome target targeting the cytokine storm therapeutic strategy Thromboembolic event Thromboembolic events thrombosis tissue damage treated Treatment Van
[DOI] 10.1182/blood-2020-141045 [Article Type] Conference abstract

Maternal and Perinatal Outcomes in Patients with Suspected COVID-19 and Their Relationship with a Negative RT-PCR Result

Article

Published on 2020-11-042022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Admission analysed Characteristics clinical clinical feature coronavirus coronavirus disease COVID-19 Critical enrolled Factor feature Final greater hospital identify IgG antibody intensive care lactate dehydrogenase LDH management Maternal maternal-perinatal outcomes Mild monocyte need for oxygen negative negative RT-PCR negative test no difference Obstetric obstetrics other variables outcome participant Patient patients Perinatal Pneumonia polymerase chain Predictive Pregnancy pregnant women proportion radiological recorded reduced relationship Result retrospective cohort study returned reverse transcription RT-PCR RT-PCR negative result RT-PCR test SARS-CoV-2 severity Spain subgroup analysis Suspected Symptom the disease the patient therapy Treatment variable virus while
[DOI] 10.3390/jcm9113552 PMC 바로가기 [Article Type] Article

Clinical impact of monocyte distribution width and neutrophil-to-lymphocyte ratio for distinguishing COVID-19 and influenza from other upper respiratory tract infections: A pilot study

COVID-19 및 인플루엔자를 다른 상부 호흡기 감염과 구별하기 위한 단핵구 분포 폭 및 호중구 대 림프구 비율의 임상 영향: 파일럿 연구

Research Article

Published on 2020-11-022022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

Parameters predicting COVID-19-induced myocardial injury and mortality

Article

Published on 2020-11-012023-07-12
Journal: Life sciences [Category] SARS,

[키워드] CD8 COVID-19 monocyte pericardial effusion SARS-CoV-2 Treg
[DOI] 10.1016/j.lfs.2020.118400 PMC 바로가기

Distinguishing between typical Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2

SARS-CoV-2와 관련된 소아의 다기관 염증 증후군(MIS-C)과 전형적인 가와사키병의 구별

Article

Published on 2020-11-012022-09-12
Journal: Medical Hypotheses [Category] 진단,

[키워드] activate Activation acute respiratory syndrome Bone marrow CD8+ cell children classical Cohort coronavirus COVID-19 debate distinguishing Fc receptor FcR help Hyperinflammatory syndrome immune immune complex Immunoglobulin Immunopathogenesis Inflammatory inflammatory cell inflammatory cells Inflammatory response Intravenous immunoglobulin IVIG Kawasaki disease kill membranes MIS-C monocyte Neutrophils paediatrics Pathogenesis Patient PIMS-TS Platelet Platelets pro-inflammatory recruitment resulting SARS-CoV-2 secreted significantly lower stimulate suppress syndrome these cell thought viral infected cells virus
[DOI] 10.1016/j.mehy.2020.110263 PMC 바로가기 [Article Type] Article

COVID-19 in a multiple sclerosis (MS) patient treated with alemtuzumab: Insight to the immune response after COVID

알렘투주맙으로 치료받은 다발성 경화증(MS) 환자의 COVID-19: COVID 이후의 면역 반응에 대한 통찰력

Case Reports

Published on 2020-11-012022-09-12
Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단,

BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

COVID-19에 대한 타고난 면역 반응을 개선하기 위해 브라질에서 의료 종사자의 BCG 재접종: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-262022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] accompany activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Antibiotics antiviral immune response approved assigned Autoimmune Autoimmune diseases Bacillus BCG BCG revaccination BCG vaccination bcg vaccine blinded Blinding block blocks both groups Brazil Breastfeeding carried CFU Characteristics Chemotherapy childhood city clinical trial Committee Comorbidities Comorbidity confirmation Contact contact with control group Coronavirus-2 COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptoms COVID-19 test cross-protection determined by diagnosed direct contact disease disease severity Diseases dissemination dose doses Effectiveness element elicited eligibility criteria Fever health worker health workers healthcare providers HIV hospital Hypothesis ICU identification number IgG and IgM IgM and IgG IgM test immunosuppressive IMPROVE in both group incidence incidence of COVID-19 Inclusion inclusion criteria India induce Infection infections information innate immune response investigator Laboratory lateral flow less macrophages medication meet memory monocyte Monocytes Mortality naso-oropharyngeal swab neutrophil Neutrophils NK NK cell number Nurses objective Open-label outcome outcomes pandemic parallel-group participant physiotherapists platform presenting Prevent Primary outcome Primary outcomes professional protocol randomisation randomised randomised controlled trial randomization Randomized receive recruit recruitment reduce Registered registration number researcher researchers respiratory revaccination right arm RT-PCR Sample size SARS-CoV-2 scar sealed Secondary objective Secondary objectives secondary outcome severe acute respiratory syndrome Coronavirus severity solid tumour specimen statistical analyses status steroid Study protocol Symptom symptomatic infection the disease the vaccine Trial Trial registration Tuberculosis two groups vaccination Vaccine virus virus infection virus infections was performed website WHO
[DOI] 10.1186/s13063-020-04822-0 PMC 바로가기 [Article Type] Letter

A Longitudinal Study of Immune Cells in Severe COVID-19 Patients

중증 COVID-19 환자의 면역 세포에 대한 종단 연구

Clinical Trial

Published on 2020-10-232022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 임상,

[키워드] adaptive Admission Anti-inflammatory antigen-specific polyfunctional T-cells Biomarker CD14 CD16 CD4 T-cell CD8 CD8 T-cell classic clinical Clinical severity consecutive patient COVID-19 defect expression functional HLA-DR immune response immune responses Immunity immunostimulatory inflammation marker inflammation markers intensive care intensive care unit intensive care unit admission intermediate knowledge less longitudinal lymphocyte Lymphocyte subsets lymphopenia monocyte monocyte HLA-DR Monocytes nadir nucleoprotein patients peptides recorded reduction in Registration SARS-CoV-2 SARS-CoV-2 peptides severe COVID-19 severe COVID-19 patients spike subset T-cell T-cells therapeutic decision therapeutic decisions threshold Vaccine design Variation
[DOI] 10.3389/fimmu.2020.580250 PMC 바로가기 [Article Type] Clinical Trial