A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive보존된 DNA 반복은 게놈 아카이브에서 트리파노소마 브루세이 표면 항원의 다양한 레퍼토리 선택을 촉진합니다Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated addition African African trypanosomiasis antigenic variation archive assumption bloodstream catastrophic Cell cell cycle Chromosomal translocation Chromosomal translocations chromosome chronic condition conserved demonstrated DNA DNA sequence Donor event expression gene conversion genetic change Genome genomic homolog homology Host Hypothesis identify implicated induce infect Infection iteration mammalian manipulation natural infection observation observé outcome parasite pathogen Pathogens promote Protein proximal Recombination recombination event reduction in Region Repeat repertoire required selected Selection sequence silent species Support surface Surface glycoprotein switching synthetic tested the cell These data transcribed translocation Trypanosoma Trypanosoma brucei Trypanosome trypanosomiasis Variant Surface Glycoprotein VSG [DOI] 10.1371/journal.pgen.1005994 PMC 바로가기 [Article Type] Research Article
Hendra Virus Infection in Dog, Australia, 2013Article Published on 2015-12-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Australia dog Hendra virus natural infection pathology Virology viruses [DOI] 10.3201/eid2112.151324 PMC 바로가기
Detection and characterisation of hepatitis E virus in naturally infected swine in CroatiaArticle Published on 2013-12-012023-06-11 Journal: Acta veterinaria Hungarica [Category] E형 간염, [키워드] Croatia Hepatitis hepatitis E virus HEV natural infection swine zoonotic potential [DOI] 10.1556/AVet.2013.031
Incidence of Influenza A(H1N1)pdm09 Infection, United Kingdom, 2009–2011Dispatch Published on 2013-11-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Adult Cohort studies England Epidemiology Human influenza incidence Influenza A(H1N1)pdm09 natural infection pandemic influenza Pandemics Seroepidemiology Seroprevalence United Kingdom viruses [DOI] 10.3201/eid1911.130295 PMC 바로가기 [Article Type] Dispatch
Natural infection in anopheline species and its implications for autochthonous malaria in the Atlantic forest in Brazil아마노필린 종의 자연 감염과 브라질 아틀란틱 숲에서의 자생 말라리아에 대한 그 함의Research Published on 2013-03-072024-08-13 Journal: Parasites & Vectors [Category] 말라리아, [키워드] Anophelines Atlantic forest Autochthonous malaria natural infection Plasmodium [DOI] 10.1186/1756-3305-6-58 PMC 바로가기 [Article Type] Research
Comparison of Immune Response by Virus Infection and Vaccination to 2009 Pandemic Influenza A/H1N1 in ChildrenArticle Published on 2013-02-282023-06-09 Journal: Journal of Korean medical science [Category] 신종인플루엔자, [키워드] Child immune response natural infection pandemic influenza A vaccination [DOI] 10.3346/jkms.2013.28.2.274 PMC 바로가기
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article
The dominance of human coronavirus OC43 and NL63 infections in infantsArticle Published on 2011-12-192022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] 229E addition childhood children determine disease elicit Epidemiology explain Frequency HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 healthy children HKU1 hospital Hospitalized human coronavirus human coronavirus OC43 Immunity indication Infant infect infecting Infection infections less majority mild infection natural infection Newborn NL63 objective OC43 occur pathogenic positive PROTECT real time respiratory infection respiratory tract Result RT-PCR sequence Seroconversion seroconverted serology severe disease study group subsequent was determined [DOI] 10.1016/j.jcv.2011.11.011 PMC 바로가기 [Article Type] Article
Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution PathwayResearch Article Published on 2008-11-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 80R activity amino acid change Analysis Anti-viral Anti-viral therapy Author block caused CDR Combination complementarity determining region component Cytidine deaminase dominant driving effective elicited Epidemic epitope escape mutant escape mutants escape mutation Evidence Evolution found generate human convalescent sera immune immune pressure IMPROVE Infected Infectious disease information introduced investigated Mutagenesis NAb natural infection neutralization neutralization activity neutralizing antibody non-immune outbreak pathway Pathways Positive selection Protein provided response responses against responsible SARS Coronavirus SARS-CoV SARS-CoV spike protein Somatic Spike protein strain Strategy Support Therapies transfer Transmission viral variant virus viruses while zoonotic zoonotic transmission [DOI] 10.1371/journal.ppat.1000197 PMC 바로가기 [Article Type] Research Article
Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantResearch Article Published on 2008-10-242022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] alteration amino acid substitution Analysis antigen-specific T cell association Author CD8+ T cell changes in clinical disease complex Complex molecule conformation Consensus Critical CTL cytotoxic determinant Disease progression Diseases elicit Enhancing epitope escape expressed functional Hepatitis histocompatibility HIV immune response immune responses immunodominant Infected Local Major memory MHC class I mice molecular basis motif mouse hepatitis mutated Mutation natural infection occur pathogen peptide performed prevention PROTECT Protective recombinant residue response significantly higher stability Subdominant T cell T cell epitope T cell response tumor immunity Vaccine development viral infection virus wildtype [DOI] 10.1371/journal.ppat.1000186 PMC 바로가기 [Article Type] Research Article