Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells
Antiviral Agents
[키워드] Alanine
Antiviral
antiviral activity
biochemical
bioinformatic analysis
carboxylesterase 1
CatA
catalytic
cathepsin A
Cell culture
cells
cellular
CES1
COVID-19
Critical
data sets
demonstrated
Effect
enzyme
Enzymes
GS-5734
HINT1
histidine
Human
human lung tissue
hydrolyzed
Hypothesis
inhibitor
involved
lung
lung cells
metabolic
metabolism
monophosphate
mRNA
mRNA expression
nucleotide analogs
nucleotide-binding protein 1
pathway
phosphorylated
Phosphorylation
polymerases
prodrug activation
Protein
quantification
RDV
Remdesivir
respiratory viral infection
RNA-Seq
SARS-CoV-2
selective
sequence
single-cell
Support
target cell
tissue
treat
Treatment
turn
unique
Viral RNA
[DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents
[DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents