Antibodies Responses to SARS-CoV-2 in a Large Cohort of Vaccinated Subjects and Seropositive PatientsArticle Published on 2021-07-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age analyses antibody Antibody concentrations Antibody Response Antigen BNT162b2 collected Concentration COVID-19 COVID-19 vaccination COVID-19 vaccine IgG IgG antibody immunization Male sex multivariable natural infection Older age per day persistence regression analysis required response S1/S2 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 vaccination serological significantly socio-demographic statistically statistically significant reduction subject Support the disease the SARS-CoV-2 vaccination Vaccine Vaccine development [DOI] 10.3390/vaccines9070714 PMC 바로가기 [Article Type] Article
Asymptomatic COVID-19 re-infection in a Japanese male by elevated half-maximal inhibitory concentration (IC 50) of neutralizing antibodies중화항체의 최대 억제 농도(IC 50) 상승에 의한 일본 남성의 무증상 COVID-19 재감염Case Reports Published on 2021-07-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] MERS, SARS, 진단, [키워드] Analysis analyzed anti-SARS-CoV-2 Anti-Spike protein IgG antibody Asymptomatic Characteristics Clinical characteristics clinical information collected Concentration COVID-19 COVID-19 symptom discharged elevated epidemiological Epidemiology half-maximal inhibitory concentration IgG IgG antibodies IgG antibody immunology Infection Japanese male Moderate COVID-19 neutralizing antibody oxygen Patient Pneumonia positive Protein Re-infection reactive remained reported RT-PCR SARS-CoV-2 serological spike tested the patient viral shedding virus with COVID-19 [DOI] 10.1016/j.jiac.2021.04.017 PMC 바로가기 [Article Type] Case Reports
Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?항인지질 항체는 단지 흔한 부수 현상입니까, 아니면 COVID-19에서 면역 매개 응고병증의 원인입니까?Review Published on 2021-07-012022-09-12 Journal: Clinical Rheumatology [Category] MERS, SARS, 진단, [키워드] abnormality addition antibody antiphospholipid antibodies association case sery catastrophic Characteristics characterized Coagulopathy cohort study conducted coronavirus disease COVID-19 COVID-19 patients develop disease elevated Evidence Frequency Government hallmark hematology identify Immune-mediated Inflammation investigated involved manifestation mechanism Mortality Occurrence Organ failure pathogenic Patient patients with COVID-19 prognostic biomarker public health emergency self-antigen serological Society syndrome thrombosis to define Topic vascular thrombosis viral infections [DOI] 10.1007/s10067-021-05724-5 PMC 바로가기 [Article Type] Review
Assessing the Quality of Serological Testing in the COVID-19 Pandemic: Results of a European External Quality Assessment (EQA) Scheme for Anti-SARS-CoV-2 Antibody DetectionCOVID-19 팬데믹에서 혈청학적 검사의 품질 평가: Anti-SARS-CoV-2 항체 검출을 위한 유럽 외부 품질 평가(EQA) 계획의 결과Immunoassays Published on 2021-06-302022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Antibody detection Antibody titers Assessing assessment blinded country COVID-19 COVID-19 pandemic Cutoff detection diagnostic diagnostic procedures diagnostic sensitivity diagnostics distribution drop EQA Europe European External external quality assessment scheme harmonization help highlight human serum IgA IgG IgM IgM antibodies Immunity immunoassays IMPROVE Improvements Laboratory lack limitation management offer open Prevalence proficiency testing provided Quality recommendation reference reported Result ring trial SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity serological serological test Serological tests serum samples technical limitations test performance test results Testing vaccine response Variability [DOI] 10.1128/JCM.00559-21 PMC 바로가기 [Article Type] Immunoassays
Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 monthsSARS CoV-2 감염에 대한 IgG 항체 반응 평가 및 측방 유동 면역 분석의 성능: 11개월에 걸친 횡단면 및 종단 분석Article Published on 2021-06-292022-09-11 Journal: BMJ Open [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] Abbott Abbott SARS-CoV-2 IgG anti-SARS-CoV-2 antibody antibody levels Blood Blood donations Cohort collected comprehensive analysis convalescent plasma COVID-19 cross-sectional detectable diagnostic Diagnostic microbiology diagnostics Donor Elecsy Elecsys ELISA Euroimmun evaluate healthcare worker humoral immune response IgG IgG antibodies IgG antibody immunoassay immunoassays individual individuals Infection Ireland Laboratory lateral flow lateral flow immunoassay LFIA Longevity longitudinal analysis minimum molecular molecular diagnostics outcome pandemic Performance metrics persistence plasma sample plasma samples positive Post-infection post-symptom onset Rapid Rapid test Research Roche SARS CoV-2 SARS-CoV-2 antibody SARS-CoV-2 ELISA SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 spike protein sensitivity Sensitivity and specificity serological specificity Spike protein Test [DOI] 10.1136/bmjopen-2020-048142 PMC 바로가기 [Article Type] Article
Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severitySARS-COV-2에 대한 3 개의 혈청 발광 면역 분석 및 질병 중증도에 대한 항체 지수의 임상 적 중요성의 비교Comparative Study Published on 2021-06-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 진단, 치료법, [키워드] (Abbott Abbott access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody automated Beckman Coulter chemiluminescence immunoassay clinical implication clinical implications clinical marker clinical markers Clinical severity Clinical significance collected coronavirus correlation correlation coefficient COVID-19 disease disease severity IgG IgG antibody IgM immunoassay Infection investigated Molecular tests nucleocapsid nucleocapsids Patient patients with COVID-19 Quantitative respiratory Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV2 serological severe acute respiratory syndrome Coronavirus severe disease Siemens significantly significantly higher specimen spikes statistically the SARS-CoV-2 Total was measured [DOI] 10.1371/journal.pone.0253889 PMC 바로가기 [Article Type] Comparative Study
Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infectionSARS-CoV-2 감염 연구를 위한 최고의 항원 및 최고의 면역 바이오마커를 식별하기 위한 탐색적 분석Research Published on 2021-06-262022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] acute COVID-19 Analysis Antibody Response Antigen approach AUC best Biomarker Biomarkers Clinical characteristics cohorts COVID-19 demonstrated described develop diagnostics discriminant analysis Disease progression Eotaxin evaluate evaluated Factor FGF foundation G-CSF GM-CSF HCV help highest identify IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-17A IL-1ra IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 immune immune factors immune response Immunity immunogenic immunogenicity induce Infectious disease IP-10 knowledge MCP-1 membrane MIP-1α MIP-1β not affect nucleoprotein ORF3a partial least square Patient PDGF peptide peptide pool peptides RANTES recent recovered patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV2 SARS-CoV2 infection serological spike Spike-based vaccine spike-protein T-cell T-cell Response TNF-α Treatment strategies Tuberculosis Vaccine vaccine candidates vaccine trial VEGF Viral Viral antigen virus Whole-blood [DOI] 10.1186/s12967-021-02938-8 PMC 바로가기 [Article Type] Research
A newly identified linear epitope on non-RBD region of SARS-CoV-2 spike protein improves the serological detection rate of COVID-19 patientsSARS-COV-2 스파이크 단백질의 비 RBD 영역에서 새로 확인 된 선형 에피토프는 COVID-19 환자의 혈청 학적 검출 속도를 향상시킵니다.Research Published on 2021-06-262022-09-01 Journal: BMC Microbiology [Category] MERS, 진단, 치료기술, [키워드] addition analyzed antibody Antigen asymptomatic infection asymptomatic infections asymptomatic patients B cell B cell linear epitopes Combination convalescent sera convalescent serum convenience correlation COVID-19 patient detect detection rate ELISA epitope epitope peptide Epitopes exhibited fast feasibility highest Humoral immunity identify IMPROVE Infectious disease Infectious diseases information lack linear linear epitopes lowest medium neutralizing antibody overlapping Patient peptide peptide-based peptides positive positive correlation positive rate Protein reaction rate reactivity reported Research Result S protein SARS-CoV-2 SARS-CoV-2 spike protein serological serological data serum samples significantly Spike protein subsequent supplementary material Support the S protein titre total patient total patients with COVID-19 [DOI] 10.1186/s12866-021-02241-y PMC 바로가기 [Article Type] Research
Rapid Point-Of-Care Serology and Clinical History Assessment Increase Protection Provided by RT-PCR Screening: A Pilot Study Involving Three Nursing Homes in Brescia, a Hotspot of LombardyPublic Health Published on 2021-06-242022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] antibody assessment Asymptomatic Asymptomatic disease asymptomatic transmission Brescia Care clinical clinically close contact COVID-19 COVID-19 symptoms demonstrated diagnostic test effort Fisher had more history home include increase Infection Involving Italy less lombardy Measures Nursing nursing home Older on-site testing outbreak positive positive RT-PCR positive serology professional protection Protective questionnaire Rapid rapid serological assays Registered RT-PCR RT-PCR screening SARS–CoV−2 sensitivity serological serology serology test specificity Symptom tested the disease Transmission viral spread was performed [DOI] 10.3389/fpubh.2021.649524 PMC 바로가기 [Article Type] Public Health
A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patientsCOVID-19 환자에서 항-스파이크 항체의 혈청 학적 검출을위한 유세포 분석법 분석Protocol Published on 2021-06-192022-09-01 Journal: STAR protocols [Category] MERS, SARS, 진단, 치료기술, [키워드] Abstract anti-spike antibody antibody capture Cell Cell Biology cell surface Cloning complement Complete coronavirus coronavirus 2019 disease COVID-19 COVID-19 patient Cytometry detect Early detection eGFP Express Flow flow cytometry Flow Cytometry/Mass Cytometry full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein Health Sciences immunology infected individual infected individuals insertion limit management Molecular biology patients with COVID-19 PCR-based assays Plasmid protocol public health S protein SARS-CoV-2 spike SARS-CoV-2 spike protein serological Serological assay serological assays specific antibodies specific antibody Spike protein the cell the S protein transduced transfection transfer Transmission Viral viral particle Viral particles [DOI] 10.1016/j.xpro.2021.100671 PMC 바로가기 [Article Type] Protocol