Does “Flattening the Curve” Affect Critical Care Services Delivery for COVID-19? A Global Health PerspectivePerspective Published on 2020-12-072022-10-29 Journal: International journal of health policy and managem [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome alleviate coronavirus coronavirus disease COVID-19 COVID-19 cases Critical care delivery global health global pandemic health system Infection intensive care units measure mitigate pandemic Personal protective equipment PPE PROTECT Resource Use SARS-CoV-2 service Spread while [DOI] 10.34172/ijhpm.2020.117 PMC 바로가기 [Article Type] Perspective
FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2020-12-042022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activity alleviate Anti-inflammatory anti-inflammatory drug antimicrobial drugs Antiviral antiviral activity approach Azithromycin binding Combination coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patients disease drug Drug discovery Drug repurposing drugs Evidence food Hydrogen bond impair in vitro Interaction Ligand MERS-CoV Middle East niclosamide nitazoxanide PDB peptide Piroxicam potent protease provided reduce Replication reported respiratory respiratory symptoms SARS-CoV-2 SARS-CoV-2 replication spike glycoprotein tested Therapeutic benefit Virtual screening [DOI] 10.3390/ph13120443 PMC 바로가기 [Article Type] Article
Mental health status of Chinese residents during the COVID-19 epidemicResearch Article Published on 2020-12-032022-10-27 Journal: BMC Psychiatry [Category] COVID-19, [키워드] activity affected alleviate Analysis Anxiety anxiety symptom anxiety symptoms China Chinese cognitive cognitive training collected data COVID-19 COVID-19 epidemic COVID-19 pandemic death Depression depressive depressive symptom effective exhibited Factor Factors female gender groups growth Health status identify Logistic regression analysis Mental mental health Mild moderate multiple logistic regression Negative cognitive processing bias negatively affected Older Participants positive Prevalence Psychological intervention questionnaire reducing Regulatory Result Stress the epidemic was used [DOI] 10.1186/s12888-020-02966-6 PMC 바로가기 [Article Type] Research Article
Mental health status of Chinese residents during the COVID-19 epidemicResearch Article Published on 2020-12-032022-10-27 Journal: BMC Psychiatry [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] activity affected alleviate Analysis Anxiety anxiety symptom anxiety symptoms China Chinese cognitive cognitive training collected data COVID-19 COVID-19 epidemic COVID-19 pandemic death Depression depressive depressive symptom effective exhibited Factor Factors female gender groups growth Health status identify Logistic regression analysis Mental mental health Mild moderate multiple logistic regression Negative cognitive processing bias negatively affected Older Participants positive Prevalence Psychological intervention questionnaire reducing Regulatory Result Stress the epidemic was used [DOI] 10.1186/s12888-020-02966-6 PMC 바로가기 [Article Type] Research Article
In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients기능 강화 분석과 결합된 인실리코(in silico) 면역 침투 프로파일링은 COVID-19 환자의 폐에서 심각한 면역 반응을 유발하는 촉발제로서 순진한 B 세포의 잠재적 역할을 보여줍니다Research Article Published on 2020-12-022022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, [키워드] Activation acute respiratory distress acute respiratory distress syndrome alleviate Analysis antibody antibody-secreting cells antiviral drugs applied ARDS B cell B cells B-cell B-cells cause caused Clinical outcome Clinical treatment collected country COVID-19 COVID-19 case COVID-19 group COVID-19 patient COVID-19 patients DN2 effective effort evaluate excessive immune response fibrosis functional functional enrichment Gene Expression genetic difference genetic differences humoral immune response Idiopathic pulmonary fibrosis Immune cell Immune cell infiltration immune infiltration immune response immune responses impairment infiltration IPF leads lung lung damage Lung function lung tissue lung tissues mechanism memory Mild mitigate modulating naïve naïve B cell naïve B cells Patient Pneumonia populations pulmonary fibrosis reducing resource respiratory distress resulting reveal SARS-CoV-2 SARS-COV-2 infection Severe patient severe patients severe pneumonia severe symptom severe symptoms significantly Single-cell RNA sequencing spread to subset subtype syndrome targets therapy transcriptional transcriptomic treated Trigger variety [DOI] 10.1371/journal.pone.0242900 PMC 바로가기 [Article Type] Research Article
The Social Brain and Emotional Contagion: COVID-19 EffectsReview Published on 2020-11-252022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] alleviate analyzed Anxiety Brain Central nervous system children Clinical outcome consequence Contagion contagious contributing to coronavirus Coronavirus disease 2019 cortical COVID-19 COVID-19 infection death delirium Depression described driven by Effect emotional emotional contagion examined feature global pandemic Health impairment IMPROVE include individual Infectious disease Interaction knowledge memory mental health mental health problems neurocognitive Neurological disorder other coronavirus outbreak outcome pandemic pathway responses responsible social interaction Stress Symptom therapeutic approaches translated with COVID-19 [DOI] 10.3390/medicina56120640 PMC 바로가기 [Article Type] Review
Modeling and interpreting the COVID-19 intervention strategy of China: A human mobility viewResearch Article Published on 2020-11-242022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] alleviate analyzed applied approach China Chinese country COVID-19 dataset dissemination Epidemic epidemiological hazard Interpretation Intervention lockdown mitigate modeling outbreak pandemic parameter prevalent Prevent public health Public health intervention risk Spread the disease the epidemic Transmission virus Volume Wuhan [DOI] 10.1371/journal.pone.0242761 PMC 바로가기 [Article Type] Research Article
COVID-19–Related Internet Search Patterns Among People in the United States: Exploratory AnalysisOriginal Paper Published on 2020-11-232022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] accounted alcohol alleviate CDC center Clinical sign Control coronavirus COVID-19 COVID-19 outbreak database determine Google Government health information Health Organization identify infodemic infodemiology information information seeking infoveillance Internet majority media Modification natural language processing NLP objective organizations pandemic Patient pattern physician prevention provided question Result searched Symptom Symptoms the disease the United State The United States the WHO Topic Transmission Treatment turn virus website WHO World Health Organization [DOI] 10.2196/22407 PMC 바로가기 [Article Type] Original Paper
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress SyndromeResearch Article Published on 2020-11-202022-10-28 Journal: Analytical Cellular Pathology (Amsterdam) [Category] COVID-19, Fulltext, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome aerosol alleviate alveolar injury ARDS Characteristics clinical study conducted coronavirus country COVID-19 COVID-19 infection described disease drug etiological agent Immune cell life-threatening lung Lung inflammation modulation molecular mechanism MSC MSCs New coronavirus oxygen supply pathogenic penetrate Potential Prevent provided respiratory responsible SARS-CoV-2 Secretome severe pneumonia STEM stem cell Support syndrome therapeutic therapeutic potential therapy Vaccine virus [DOI] 10.1155/2020/1939768 PMC 바로가기 [Article Type] Research Article
A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical NeedsPharmacology Published on 2020-11-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome alleviate anti-viral agents antiviral agent Antiviral effect Asymptomatic benefit blunt children China Chinese Chloroquine clinical clinical evidence clinical trial convalescent plasma coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Critical critical COVID-19 patient cytokine release Cytokine release syndrome drug early stage Efficacy Favipiravir highlight Hydroxychloroquine in vitro Inflammation inhibit inhibitor initial interferon interleukin-6 interleukin-6 inhibitors late stage Mild MOST Negative conversion non-randomized observational study pandemic Patient patients with COVID-19 Pediatric case Prophylaxis repurposing review ribavirin sample-size SARS-CoV-2 severe COVID-19 patient severe patients small sample size Study design therapeutic option therapy Traditional Chinese medicine Treatment treatment initiation with mild disease [DOI] 10.3389/fphar.2020.584956 PMC 바로가기 [Article Type] Pharmacology