Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBDArticle Published on 2022-02-152022-10-04 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] ACE2 acute respiratory syndrome affinity antibody Autoimmunity Beta binding epitope characterized Contact coronavirus Cryoelectron microscopy Delta eliminated enzyme Epidemic epitope experiment globe high affinity highlight hydrophobic in vitro inhibitory concentration Interaction Microscopy monoclonal antibody Mutation neutralization neutralize neutralized overlap RBD Receptor binding domain rhesus SARS-CoV-2 SARS-CoV-2 variant Spike protein Spike proteins therapeutic therapeutic efficacy therapy Tolerance transgenic mice Transmissibility Vaccine variants of concern viral burden VoC VOCs [DOI] 10.1038/s41421-022-00381-7 PMC 바로가기 [Article Type] Article
Structural racism and COVID-19 response: higher risk of exposure drives disparate COVID-19 deaths among Black and Hispanic/Latinx residents of Illinois, USAResearch Published on 2022-02-152022-10-28 Journal: BMC Public Health [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] addition age all age groups black calculated case fatality ratio Community COVID COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death death rate deaths diagnostic testing diagnostic tests disease disparate disparity drastic driver driving employment Epidemic Factor fatality groups Health healthcare help higher risk identify Illinois incidence individual Intervention lack less Local Mortality outcome Population populations Public Racial disparities reached reduce reducing Relative risk Result resulting risk risk of COVID-19 SARS-CoV-2 significantly increased stratified supplementary material System the epidemic The United States USA white [DOI] 10.1186/s12889-022-12698-9 PMC 바로가기 [Article Type] Research
Increased Circulating Cytokines Have a Role in COVID-19 Severity and Death With a More Pronounced Effect in Males: A Systematic Review and Meta-AnalysisPharmacology Published on 2022-02-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome article Asian caused circulating claimed coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity COVID-2019 cytokine Cytokines Cytokines storm death death group demonstrated driving Effect elevated Epidemic European Evidence Factor females groups high mortality identify IL-10 IL-17 IL-1β IL-4 IL-6 IL-8 Increased increased mortality Inflammatory cytokine interleukin-6 key factor male Meta-analysis Mortality much higher Necrosis non-survivor Patient patients potential risk predisposition receptor review risk of bia role SARS-CoV-2 screened searched Serum level severity Sex Sex bias significantly the mean TNF-α upregulation Web of Science were measured [DOI] 10.3389/fphar.2022.802228 PMC 바로가기 [Article Type] Pharmacology
Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2Original Article Published on 2022-02-142022-10-30 Journal: Natural Products and Bioprospecting [Category] COVID-19, [키워드] 2019 novel coronavirus 3CLpro accumulated ACE ACE2 activity anti-inflammatory activity antiviral agent assumed caused Citrus Citrus flavonoids clinically coronavirus cough COVID-19 cytokine Cytokine storm death digestive effective ENhance enzyme Epidemic expression Health hesperetin HMGB1 host immunity identification IL-1β IL-6 immunoregulation in vitro in vivo experiment indicated inhibit inhibiting inhibitor LPS macrophage cell line molecular docking naringenin naringin Novel coronavirus outbreak Pneumonia predict Proinflammatory cytokine receptor SARS-CoV SARS-CoV-2 SARS-COV-2 infection subsequent supplementary material sweet the binding affinity Treatment Wuhan [DOI] 10.1007/s13659-022-00325-4 PMC 바로가기 [Article Type] Original Article
Machine-learning based prediction of prognostic risk factors in patients with invasive candidiasis infection and bacterial bloodstream infection: a singled centered retrospective studyResearch Published on 2022-02-132023-08-29 Journal: BMC Infectious Diseases [Category] E형 간염, [키워드] bacterial bloodstream infection China Epidemic Invasive candidal infection machine learning [DOI] 10.1186/s12879-022-07125-8 PMC 바로가기 [Article Type] Research
Test-trace-isolate-quarantine (TTIQ) intervention strategies after symptomatic COVID-19 case identification증상 COVID-19 사례 식별 후 시험-트레이스-이 솔 레이트-쿼란 틴 (TTIQ) 중재 전략Research Article Published on 2022-02-112022-09-10 Journal: PLoS ONE [Category] MERS, 변종, [키워드] Asymptomatic Asymptomatic cases can be used carrier close contact Community confirmed case confirmed cases Contact Contact tracing COVID-19 case COVID-19 pandemic develop disease disease outbreak disease symptoms disease transmission distribution Epidemic Epidemics fraction Frequency growth hygiene increase inherent Intensive Intervention Isolation majority make up mathematical mathematical model methodology outbreak parameter pathogen prevented Probability protocol Quantification method quarantine reproductive SARS-COV-2 infection social distancing measures suppress symptom onset symptomatic symptomatic individual symptomatic individuals tested the timing Transmission utilised Vaccine variant [DOI] 10.1371/journal.pone.0263597 PMC 바로가기 [Article Type] Research Article
Prehospital Testing and Surveillance for SARS-CoV-2: A Special Report from the Sacramento (California USA) Mobile Integrated Health UnitResearch Report Published on 2022-02-112022-10-29 Journal: Prehospital and Disaster Medicine [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] affected agency ALF, assisted living facilities American Americans BCF, board and care facility Care caused CDC, Centers for Disease Control and Prevention CMS, Centers for Medicaid and Medicare Services Cohort cohort of patient collected congregate living Cooperative coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19, Coronavirus disease 2019 demographic Department disease Disease surveillance effective Emergency EMS, Emergency Medicine Services Epidemic Epidemics female health equity identify Infection joint laboratory data majority median age men MIH-CP, Mobile-Integrated Healthcare Community Paramedicine MIH, Mobile Integrated Health Unit Mobile mobile care delivery Older Pandemics Patient positive prehospital Prevalence PSY, inpatient psychiatric facilities psychiatric facility Public report respiratory retrospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SCDPH, Sacramento County Department of Public Health service SNF, skilled nursing facilities study period Surveillance tested Testing unit USA was measured [DOI] 10.1017/S1049023X22000292 PMC 바로가기 [Article Type] Research Report
Epidemiological and clinical insights from SARS-CoV-2 RT-PCR crossing threshold values, France, January to November 2020SARS-CoV-2 RT-PCR 교차 임계값의 역학 및 임상 통찰력, 프랑스, 2020년 1월~11월Research Published on 2022-02-102022-09-10 Journal: Eurosurveillance [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] age Analysis ARIMA average Biology COVID-19 COVID-19 epidemic COVID-19 pandemic Cq value Cq values database Diagnosis distribution Epidemic epidemiological Epidemiology error France General population generate help hypothese IMPROVE Infection information intensity Laboratory Linear regression model linear regression models moving average pandemic Patient patient age performed quantification quartile quartiles reduced Reproduction number Result RT-PCR RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR screening test screening tests Spread Statistical modelling Surveillance symptoms onset test result the epidemic threshold virus load [DOI] 10.2807/1560-7917.ES.2022.27.6.2100406 PMC 바로가기 [Article Type] Research
Determining the Case Fatality Rate of COVID-19 in Italy: Novel Epidemiological StudyOriginal Paper Published on 2022-02-102022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] analyzed ArcGIS assigned calculate calculated Case fatality rate center CFR country COVID-19 death Determining discharged discharged case fatality rate distribution Emilia-Romagna Epidemic epidemiological data fatality Fatality rate first stage highest Italy Lombardia new infectious diseases novel objective Perspective predict proportion public health rapid increase Rate regression analysis Result retrieved selected Spread the epidemic the United State [DOI] 10.2196/32638 PMC 바로가기 [Article Type] Original Paper
SARS-CoV-2 antibodies protect against reinfection for at least 6 months in a multicentre seroepidemiological workplace cohortSARS-CoV-2 항체는 다기관 혈청역학 작업장 코호트에서 최소 6개월 동안 재감염으로부터 보호합니다.Multicenter Study Published on 2022-02-102022-09-12 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI analysed Analysis association baseline calculate choice Cohort conducted confounder confounders Epidemic highlight identifying individuals majority multicentre multivariable logistic regression Odds ratio PCR PCR positive PCR test point estimates Primary infection prospective cohort PROTECT provide reduced Reinfection Relative risk risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serological Serological testing subsequent test result United State United States [DOI] 10.1371/journal.pbio.3001531 PMC 바로가기 [Article Type] Multicenter Study