Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa차세대 "-omics" 접근 방식으로 녹농균(Pseudomonas aeruginosa)의 박테리오파지 감염 동안 숙주 RNA 대사의 대규모 변경이 밝혀짐Research Article Published on 2016-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Analysis approaches Bacteria Bacterial bacterial strains bacteriophage bacteriophages block changes in characterized coding Complete Course Degradation demonstrated drastic early stage Escherichia coli expressed family Gene Expression generate highlight Host infecting Infection infection cycle infection cycles Interaction interfere involved knowledge lifecycle massive metabolic pathway metabolic pathways metabolism metabolomics molecular molecular mechanism molecular mechanisms multidrug resistant nucleotide opportunistic pathogen pathogen produced promote proportion Pseudomonas aeruginosa pyrimidine Regulation required RNA RNA-sequencing RNAs shown stimulate strain suggested therapeutic therapeutic potential therapy transcript transcriptomics treat Trigger triggers Viral viral replication Viral RNA viral RNAs virulent virulent phage virus viruses [DOI] 10.1371/journal.pgen.1006134 PMC 바로가기 [Article Type] Research Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections, Tunisia, 2013Dispatch Published on 2014-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] ARDS Diagnosis family Family cluster ICU Infection MERS coronavirus MERS-CoV Middle East Middle East respiratory syndrome PCR respiratory respiratory syndrome coronavirus respiratory tract sample reverse transcription PCR Saudi Arabia sequence serum Tunisia United Arab Emirates viruses were infected [DOI] 10.3201/eid2009.140378 PMC 바로가기 [Article Type] Dispatch
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific AbortifacientsRNA-seq 분석을 통해 태생 곤충에서 식별된 매우 다양한 새로운 단백질 패밀리: 체체 파리 관련 낙태 환자의 잠재적 표적Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abortifacient addition African Amino acid amino acid sequence Analysis approaches casein cattle causative agents characterization coding control mechanisms Critical Differential analysis enrichment Factor family fecundity female functional genes encoding Genome genomic homeostasis Human Identified identify indicate insect Interference knockdown lactating lactation lipid metabolism maintenance mammalian mechanism mechanisms metabolism mother s milk novel occur organized Potential progeny Protein protein level protein synthesis Proteins proteome provided reduce reduced reducing Region reproductive resource RNA-Seq RNA-seq data secretion sequence similarity Seven shown similarities sleeping sickness specificity suppression synthesis target to define transcript Transcriptome transcripts Transferrin tsetse tsetse flies tsetse fly unique variant Viviparous were expressed while [DOI] 10.1371/journal.pgen.1003874 PMC 바로가기 [Article Type] Research Article
Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan연령, 성별 및 암은 아니지만 신경퇴행성 및 심혈관 질환은 수명에 대한 아포지단백 E4 대립유전자의 전신 효과를 강력하게 조절합니다Research Article Published on 2014-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adverse effect age allele Analysis ApoE APOE gene ApoE4 allele ApoE4 carrier APOE4 carriers Apolipoprotein Apolipoprotein e association Author Cancer cardiovascular cardiovascular and neurodegenerative diseases cardiovascular disease carriers Cohort cohorts compared CVD death deaths disease Diseases e4 allele e4 allele carrier e4 allele carriers e4 carrier e4 carriers Effect Enduring ENhance explain extreme family Family Study genetic origin genetic origins genotyped ApoE polymorphism Geriatrics Gerontology healthy heart Human human disease human diseases increase interfere large sample lead life Life expectancy lifespan Long Longitudinal studies Major mechanism mechanisms men moderate Mortality neurodegenerative neurodegenerative disorder neurodegenerative disorders Non-skin cancer offspring old ages participant polymorphism Population populations Relative risk resulting risk risk of death sensitivity skin cancer survival systemic women [DOI] 10.1371/journal.pgen.1004141 PMC 바로가기 [Article Type] Research Article
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, ChinaArticle Published on 2013-10-162023-05-31 Journal: Infection [Category] Fulltext, 조류인플루엔자, [키워드] asymptomatic infection Avian influenza A (H7N9) family Neutralizing antibody titer oseltamivir [DOI] 10.1007/s15010-013-0533-9 PMC 바로가기
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article
Identification of Orch3 , a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C자가면역 고환염에 대한 지배적인 내성을 제어하는 유전자좌인 Orch3의 확인, 키네신 계열 구성원 1CResearch Article Published on 2012-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major adjuvants allele alleles animal model Antigen antigen presenting cell antigen presenting cells approach Author Autoimmune Autoimmune disease autoimmune disease susceptibility Autoimmune diseases Autoimmunity autologous characterization chromosome chromosome 11 controlling demonstrated disease disease susceptibility dominant encodes gene etiology exhibiting expression family family member Gene Genetic genetic determinant Genetic predisposition Genome histocompatibility complex identification immunization individual gene individual genes inflammatory disease Kif1c KIF21B KIF5A Kinesin leads loci locus major histocompatibility complex mapped member MHC MHC class MHC class II mice non-infectious orchitis over-expression polymorphism Polymorphisms proliferative Quantitative quantitative trait locus reduced required resistance resistant allele strain susceptibility susceptible T cell T cell responses transcriptional regulation transgenic variety [DOI] 10.1371/journal.pgen.1003140 PMC 바로가기 [Article Type] Research Article