The perceived effectiveness of MERS-CoV educational programs and knowledge transfer among primary healthcare workers: a cross-sectional surveyResearch Article Published on 2019-03-212022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] adjusted age calculated clinics Community confidence interval coronavirus country cross-sectional survey deviation dissemination education Effectiveness evaluated female FIVE foundation HCW HCWs healthcare healthcare worker highest hospital hospitals information knowledge Knowledge transfer less male males Mayo Clinic MERS MERS-CoV Middle East negative Nurses outbreak outcome Patient care patients Physicians positive Prevalence prevalent primary care Primary health respiratory syndrome coronavirus Result Sample Saudi Arabia supplementary material transfer were excluded [DOI] 10.1186/s12879-019-3898-2 PMC 바로가기 [Article Type] Research Article
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial건강한 성인에서 HIV를 예방하기 위한 아데노 관련 바이러스 매개 면역 예방: 1상 무작위 대조 시험Article Published on 2019-03-152022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] adeno-associated virus adverse event adverse events AIDS alternative analyses anti-drug antibody antibody assigned cassettes Clinical research Cohort Complete Consent detect development dose dose-escalation double-blind eligibility eligible ELISA expression finding Follow-up foundation funding Future gene delivery Gene Expression generally mild genomes groups healthy HIV HIV antibodies HIV infection immunisation induce initiative Intervention Intramuscular injection Melinda Gate Melinda Gates men moderate muscle biopsy neutralisation neutralisation activity neutralising Neutralising Antibodies neutralising antibody Phase 1 Placebo placebo-controlled Prevent provided public health quadricep quadriceps randomised randomised controlled trial Randomly reactogenicity receive Registered Research resolved RT-PCR screened Serious Adverse Event Serious Adverse Events serotype serum sustained T-cell Response T-cell responses Tolerability Trial United State United States Vaccine virus Volunteer volunteers was done were recorded [DOI] 10.1016/S2352-3018(19)30003-7 PMC 바로가기 [Article Type] Article
Community based distribution of oral HIV self-testing kits in Zambia: a cluster-randomised trial nested in four HPTN 071 (PopART) intervention communities잠비아의 커뮤니티 기반 구강 HIV 자가 테스트 키트 배포: 4개의 HPTN 071(PopPART) 중재 커뮤니티에 중첩된 클러스터 무작위 시험Article Published on 2018-12-212022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI Abuse addition adjusted odds ratio Adults AIDS allergy analysed Care care providers choice Clustering Clusters Community defined distribution door driven by drug Drug Abuse eligible Emergency Evidence evidence of female participants finding foundation funding group HIV HIV positive HIV testing Households Impact implementation individual individual level Infectious diseases initiative Interaction Intervention knowledge list Local logistic regression models Melinda Gate Melinda Gates men mental health no evidence of offer offered Older outcome plan President Primary outcome proportion provided Providing randomisation Randomly reached Registered relief remained Sex South Africa Standard of care Trial were measured women zone [DOI] 10.1016/S2352-3018(18)30258-3 PMC 바로가기 [Article Type] Article
Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial저위험 HIV 감염되지 않은 남아프리카 성인을 대상으로 한 아형 C ALVAC-HIV 및 2가 아형 C gp120/MF59 HIV-1 백신: 1/2상 시험Article Published on 2018-06-182022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI added adjuvant advancement African allergy Antigen assigned binding antibody CD4+ T-cell changed circulating clinical Community component computer-generated Critical double-blind trial Efficacy enrolled exceeded Express finding foundation funding glycoprotein gp120 HIV HIV infection HIV vaccine HIV-1 HIV-uninfected IgG IgG response immune response immune responses immunogenicity IMPROVE Infectious disease Infectious diseases Intramuscular injection investigators Melinda Gate Melinda Gates MF59 network NIAID outcome participant per-protocol per-protocol analysis Placebo predicted Primary outcomes Protein provided random randomisation randomised controlled Randomly recipient regimen Registered registry reported Research responders response risk significantly higher South South Africa strain Strains subtype T-cell Response tested the vaccine threshold titre Trial vaccination Vaccine Vaccine development was done [DOI] 10.1016/S2352-3018(18)30071-7 PMC 바로가기 [Article Type] Article
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study자궁 경부 종양에 대한 유전적 감수성 정의 - 전체 게놈 연관 연구Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele amino-acid Antigen approaches association biological basis Cancer cancer development carried cervical cancer Combination complex correlation demonstrated determine determined by DRB1 error foundation Future Genetic genetic loci genetic risk genetic risk score genetic risk scores genetic susceptibility Genetic variant genetic variants Genome-wide association study healthy controls highest HLA HLA alleles HLA haplotype HLA-B HLA-DRB1 host genetics HPV human leukocyte antigen human papillomavirus identify immune immune-related protein immune-related proteins include increased risk indicated Infection inheritance involved leukocyte major histocompatibility complex MHC MHC alleles neoplasia performed pocket Previous studies previous study Prognosis progression Protective residue risk risk factor Risk factors screening methods standard error statistical the major histocompatibility to define Treatment variant women [DOI] 10.1371/journal.pgen.1006866 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험Articles Published on 2017-05-052022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used [DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles
Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trialCD4 세포 수가 μL당 500개 이상인 HIV 양성인 사람의 중증 세균 감염 위험에 대한 항레트로바이러스 요법의 즉각적인 개시 효과: 무작위 대조 시험의 2차 결과 결과Articles Published on 2017-01-052022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI AIDS allergy analysed Analysis Antiretroviral therapy ART assigned average Bacterial Bacterial infection Bacterial infections bacterial pneumonia Bildung caused CD4 cell Cell composite endpoint Cox proportional hazard Cox proportional hazards regression Cutoff death defined described disorder Effect Endpoint enrolled European explained extrapulmonary tuberculosis Factor finding Follow-up foundation funding hazard ratio Hospital admissions Immediate Increases increases in Infectious disease Infectious diseases median Medical Research Council multivariable analysis network neutrophil neutrophil count Patient Pneumonia randomised controlled trial recruited reduce reduced risk Registered required risk secondary outcome severity subgroup subgroups Trial Tuberculosis univariable analysis [DOI] 10.1016/S2352-3018(16)30216-8 PMC 바로가기 [Article Type] Articles
Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trialHIV-1에 감염된 건강한 성인에서 후보 결핵 백신 MVA85A의 안전성, 면역원성 및 효능: 무작위, 위약 대조, 2상 시험Articles Published on 2015-03-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, [키워드] 1:1 95% CI absence active tuberculosis adverse event Antigen antigen 85A antigen 85A-specific T-cell response antiretroviral Antiretroviral therapy assigned assist baseline baseline CD4 block blocks booster Cape CD4 count CD4 counts Cell clinical defined detect detectable Developing disease double-blind effective Efficacy eligible Eligible participants enrolled enrolment European Evidence evidence of expressing finding first vaccination foundation funding gold greater Group allocation had no healthy HIV-1 HIV-1 infection immunogenic immunogenicity include increased risk Infection injection intradermal injections investigators isoniazid isoniazid prophylaxis Laboratory latent tuberculosis latent tuberculosis infection M tuberculosis Measures Melinda Gate Melinda Gates modified vaccinia virus MVA85A Mycobacterium tuberculosis nine no evidence of Nurses occurred outcome participant partnership peaked per-protocol analysis per-protocol population Phase 2 phase 2 trial Placebo placebo group placebo-controlled positive Potential Prophylaxis protocol QuantiFERON QuantiFERON-TB Gold In-Tube randomisation randomised Randomly receive receiving Registered reported Safe Safety safety analysis second vaccination secondary Secondary outcomes sequence Serious Adverse Event Serious Adverse Events significant increase South Africa stratified subset T-cell Response the placebo group therapy town Treatment Trial Tuberculosis tuberculosis disease tuberculosis vaccine undetectable vaccination Vaccine vaccine efficacy vaccine-induced immune response Viral Viral load Wellcome Trust were assessed [DOI] 10.1016/S2213-2600(15)00037-5 PMC 바로가기 [Article Type] Articles
Modeling 3D Facial Shape from DNADNA에서 3D 얼굴 모양 모델링Research Article Published on 2014-03-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affecting African age allele ancestors ancestry appearance approach Brazil BRIM Cape complex Culture cultures Deceased descendants diagnostic DNA Effect European example eyes facial feature femininity foundation Genes Genetic markers genomic Genotype Health help Human human body identify in addition to independent Intention modeling nose philtrum pool populations predict predicted Predictive provide Result RIP Sex shape significant effect spacing strength subject subset Support tested United States variable variables Variation West width [DOI] 10.1371/journal.pgen.1004224 PMC 바로가기 [Article Type] Research Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article