Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetineResearch Article Published on 2020-10-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acting Antiviral antiviral activity caused Cell culture cholesterol circulating clinically Compound coronavirus 2 COVID-19 COVID-19 severity cytotoxic effect effective endolysosomal endolysosomal interference Endosomes FIASMA Fluoxetine functional health emergency homeostasis IAV influenza A virus inhibit SARS-CoV-2 inhibited inhibitor offer pandemic respiratory Safe SARS-CoV-2 SARS-COV-2 infection Subtypes targeting therapeutic option therapy Treatment variety viral entry viruses [DOI] 10.1080/22221751.2020.1829082 PMC 바로가기 [Article Type] Research Article
A case of SLE with COVID-19 and multiple infectionsCase Report Published on 2020-10-142022-10-28 Journal: Open Medicine [Category] COVID-19, [키워드] acute respiratory syndrome antibiotic Antiviral Autoimmune disorders coronavirus coronavirus disease Corticosteroid COVID-19 dosage of hydroxychloroquine dose global pandemic Hydroxychloroquine Immunity Immunoglobulin immunosuppressive drug indicated infected with SARS-CoV-2 Infection influenza A virus multiple infections Mycoplasma pneumoniae Patient physician Prednisone PROTECT SARS-CoV-2 SARS-CoV-2 virus SLE susceptible systemic lupus erythematosus the epidemic therapy Treatment with COVID-19 [DOI] 10.1515/med-2020-0238 PMC 바로가기 [Article Type] Case Report
Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study라이노바이러스와 인플루엔자 A 바이러스의 간섭: 임상 데이터 분석 및 실험적 감염 연구Article Published on 2020-10-092022-09-10 Journal: The Lancet. Microbe [Category] MERS, 신종인플루엔자, 치료기술, [키워드] 95% CI Affect airway Analysis Antiviral blocking Cell culture cell cultures Clinical data co-occurrence Course COVID-19 pandemic Culture decrease Department Epidemic Epidemics epithelial Europe European country examination expected expression finding fluorescent Frame funding GFP green fluorescent protein H1N1 H1N1pdm09 host cell IAV idea inclusion criteria indicated Infection Influenza influenza A influenza A virus inhibit inoculated Interference interferon interferon response interferon-stimulated gene interferon-stimulated genes Intervention ISG ISGs medical record Medical Sciences Medicine Microscopy mock infection MOI mRNA mucosa Multiplex PCR multiplicity multiplicity of infection Odds ratio pandemic positive Post-infection primary human airway Protein quantitative PCR Replication reporter respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory virus restored resulting reverse transcription Reverse transcription quantitative PCR rhinovirus RNA Seasonal influenza significantly lower Spread Stimulation subsequent System tested the interferon Time frame USA Viral Viral RNA virus was used [DOI] 10.1016/s2666-5247(20)30114-2 PMC 바로가기 [Article Type] Article
In Vitro and In Vivo Antiviral Activity of Gingerenone A on Influenza A Virus Is Mediated by Targeting Janus Kinase 2Article Published on 2020-10-082023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Gingerenone A influenza A virus JAK2 p70 S6 kinase STAT3 [DOI] 10.3390/v12101141 PMC 바로가기 [Article Type] Article
Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of RecognitionReview Published on 2020-10-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] caused coronavirus Coronaviruses CoV COVID-19 pandemic CoVs death detectable Epidemic Fatality rate H1N1 HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 host range host receptor human CoVs humans IAV IBV immunologically Infection infections Influenza influenza A virus influenza B Influenza virus influenza viruses knowledge Lineage mild respiratory naïve outbreak pandemic protein receptors Receptor binding receptors Recognition recorded sialyl glycans specificity spike glycoproteins spikes structures Subtypes variants virus virus variants viruses zoonotic [DOI] 10.3390/vaccines8040587 PMC 바로가기 [Article Type] Review
Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinaseArticle Published on 2020-10-012023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] Alpha enolase influenza A virus matrix protein nucleoprotein Pyruvate kinase. [DOI] 10.1016/j.virol.2020.07.019
Total alkaloids from Alstonia scholaris inhibit influenza a virus replication and lung immunopathology by regulating the innate immune responseArticle Published on 2020-10-012023-06-23 Journal: Phytomedicine : international journal of phytother [Category] 신종인플루엔자, [키워드] acute lung injury Alstonia scholaris Anti-inflammatory influenza A virus innate immune response Total alkaloids [DOI] 10.1016/j.phymed.2020.153272
Immunodepression induced by influenza A virus (H1N1) in lymphoid organs functions as a pathogenic mechanismArticle Published on 2020-10-012023-06-23 Journal: Clinical and experimental pharmacology & physiolog [Category] 신종인플루엔자, [키워드] Apoptosis H1N1 influenza A virus lymphoid organ. [DOI] 10.1111/1440-1681.13358
Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus ReplicationArticle Published on 2020-09-272023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Antiviral endoplasmic reticulum stress influenza A virus Innate immunity thapsigargin unfolded protein response [DOI] 10.3390/v12101093 PMC 바로가기 [Article Type] Article
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological ComplicationsNeurology Published on 2020-09-252022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome ADAR angiotensin-converting enzyme 2 bioinformatics BST2 caused cells chemokines clinical symptom Complication complications of COVID-19 coronavirus correlation CoV COVID-19 COVID19 CoVs Cytokines death Dipeptidyl peptidase 4 dissemination DPP4 event expression globe IFITM3 Infection influenza A virus IRF3 ISG15 mechanism MERS-CoV Middle East morbidity MX1 MX2 neurodegeneration neuroinvasion neurologic neurological Neurological complication Neurological symptoms NF-κB pathway other molecule pandemic Pathogenesis peripheral nerve system Pneumonia Potential produced Prognosis receptor respiratory syncytial virus RNASEL robust RSAD2 SAMHD1 SAR-CoV2 SARS-CoV-1 SARS-CoV-2 Spread STRING syndrome text mining triggered Type type III interferon with COVID-19 [DOI] 10.3389/fneur.2020.562913 PMC 바로가기 [Article Type] Neurology