Innate Immune Sensing of Influenza A VirusReview Published on 2020-07-142023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Influenza virus innate immune response Pattern recognition receptors [DOI] 10.3390/v12070755 PMC 바로가기 [Article Type] Review
Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agentsResearch article Published on 2020-07-012022-10-05 Journal: Medical Hypotheses [Category] 치료제, [키워드] antibody antiviral agent Antiviral agents blocking Blood Cancer cancers CD8 CD8+ CD8+ cell Cell Chloroquine clinical trials COVID-19 COVID-19 infected patient COVID-19 patient CTLs cytokine secretion cytotoxic cytotoxicity disease Disease progression effective functional generate healthy controls healthy individuals Host immune response Immunity individual inhibiting inhibitory Innate innate immune response Innate immunity interferon lymphocyte mechanism mild infection modulated Monalizumab natural neutrophil NK cell NK cell function NK cells NKG2A Novel coronavirus outbreak over-expressing overexpression Patient Phase 2 Potential treatment receptor receptors reduced required resulting SARS SARS-CoV-2 severe COVID-19 Severe infection Side effect significantly significantly lower T-cell treated tumor growth tumor progression viral pathogen viruses weakened immune system [DOI] 10.1016/j.mehy.2020.109777 [Article Type] Research article
Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data ReuseImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence Activation addition affected approach BALF Bronchoalveolar lavage fluid caused cells characterized chemokines complex coronavirus disease COVID-19 COVID-19 patient Critical death Deceased demonstrated dysregulated expression expression of gene feature functional Humoral immunity IAV immunopathological individual Inflammation inflammatory signaling Influenza innate immune response interferon involved leukocyte leukocytes lung tissue Meta-analysis metabolic metabolic pathway metabolism mitochondrial molecular mechanism neutrophil overcome oxidative phosphorylation pandemic pathophysiology Perspective progression promote reported respiratory virus response Revealed robust SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection signature significant enrichment target the disease These data tissue transcriptional transcriptome datasets transcriptomic profile transcriptomics type I viruses [DOI] 10.3389/fimmu.2020.01636 PMC 바로가기 [Article Type] Immunology
Targeting the NLRP3 Inflammasome in Severe COVID-19Immunology Published on 2020-06-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accompanied Activation acute respiratory distress acute respiratory distress syndrome (ARDS) acute respiratory syndrome ARDS cause caused characteristic characterized Complication coronavirus coronavirus disease COVID-19 Cytokine release syndrome (CRS) Cytokine storm dissemination dysregulated family Coronaviridae fatality genus Betacoronavirus hyperinflammation IL-1β IL-1β IL-6 Infection inflammasome pathway Inflammatory cytokine innate immune response Mild NLRP3 NLRP3 inflammasome occur occurred Pathogenesis pathology pathway Proinflammatory cytokine receptor respiratory RNA virus SARS-CoV-2 SARS-COV-2 infection severe cases severe COVID-19 severe disease severe lung injury single-stranded positive-sense syndrome systemic inflammatory targeting tissue Treatment Trigger viral infection viral replication widespread [DOI] 10.3389/fimmu.2020.01518 PMC 바로가기 [Article Type] Immunology
The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathwayArticle Published on 2020-06-232022-11-01 Journal: Virus research [Category] COVID-19, SARS, 신종인플루엔자, [키워드] accessory proteins activated Activation acute respiratory syndrome aggravate antiviral response conducted contributing to coronavirus coronavirus protein COVID-19 Critical Defense dysregulation highly pathogenic Host IFN-β immune response Infection inhibit inhibited inhibiting inhibitor Innate innate immune innate immune response Innate immunity interferon interferon beta interferon-stimulated gene ISGs ISRE modulating molecular morbidity NF-κB pathway nucleocapsid protein Nucleocapsid proteins on type ORF6 ORF8 ORF8 protein pandemic promoter Protein public health reported SARS-CoV-2 SARS-COV-2 infection screened Sendai virus severe pneumonia signaling pathway structural proteins Transcription Treatment type I interferon viral infection Viral protein [DOI] 10.1016/j.virusres.2020.198074 PMC 바로가기 [Article Type] Article
IFN-I Independent Antiviral Immune Response to Vesicular Stomatitis Virus Challenge in Mouse BrainArticle Published on 2020-06-192023-08-29 Journal: Vaccines [Category] E형 간염, [키워드] CNS IFN independent pathway innate immune response ISG expression TNF-α VSV [DOI] 10.3390/vaccines8020326 PMC 바로가기 [Article Type] Article
Innate Immune Response against Hepatitis C Virus: Targets for Vaccine AdjuvantsReview Published on 2020-06-172024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] adjuvant HCV innate immune response PRRs Vaccine [DOI] 10.3390/vaccines8020313 PMC 바로가기 [Article Type] Review
Conditional cell reprogramming for modeling host‐virus interactions and human viral diseasesReview Published on 2020-06-162022-10-30 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] abnormality acute respiratory syndrome air‐liquid interface animal Antiviral antiviral drugs biopsies Cancer Cell Cell culture cell line cell senescence cell type cellular senescence change conditional reprogramming Conventional coronavirus Culture develop disease doubling Drug discovery emerging viruses Epigenetic example function functional models Genetic genetic manipulation high variability Host host cells Human in vivo infections innate immune response Interaction invasive Lineage maintain nasal noninvasive normal cells organoids passage passages physiological conditions receptor Replication Research specimens surgical specimens tissue Vaccines viral disease viral entry virus [DOI] 10.1002/jmv.26093 PMC 바로가기 [Article Type] Review
Porcine Deltacoronavirus Accessory Protein NS7a Antagonizes IFN-β Production by Competing With TRAF3 and IRF3 for Binding to IKKεCellular and Infection Microbiology Published on 2020-06-122022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] Accessory accessory protein Activation Antiviral association binding cause cells competing component coronavirus Cross-species transmission demonstrated diarrhea disrupting domain downstream evade Host IFN-β IKKε immune evasion inhibit inhibited innate immune response interact Interaction interferon IRF3 MAVS MDA5 mechanism NF-κB NS7a Porcine deltacoronavirus Production promoter Protein receptor reduction resolved RIG-I Sendai virus signaling pathway TBK1 TRAF3 transcription factor virus [DOI] 10.3389/fcimb.2020.00257 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?Review Published on 2020-06-102023-06-20 Journal: Cell Host & Microbe [Category] Fulltext, MERS, [키워드] complement COVID-19 Cytokines innate immune response myeloid cells Natural killer cells SARS-CoV-2 [DOI] 10.1016/j.chom.2020.05.009 PMC 바로가기 [Article Type] Review