Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approachesSARS-CoV-2 유도 병인 및 잠재적 진단 접근법에 대한 더 나은 이해를 위한 질량 분석 기반 단백질체 플랫폼Review Published on 2021-05-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, 진단, [키워드] AMPK applied approach Biomarkers cellular Comparative analysis comparative proteomics COVID-19 dataset diagnostic EGFR EPHA2 Ephrin functional humans in vitro experiments indicate Infection kinase kinase-substrate signaling kinases knowledge MAPK mass mass spectrometry mechanism molecular mechanism molecular mechanisms Pathogenesis pathway Pathways phosphoproteome PI3K platform post-translational modifications prognostic Protein protein targets protein-protein interaction proteome proteomic proteomics receptor SARS-CoV-2 SARS-COV-2 infection signaling pathways targeted proteomics the SARS-CoV-2 Therapeutic strategies tissue tissue sample tissue samples top-down proteomics. Viral viral infection while [DOI] 10.1002/pmic.202000279 PMC 바로가기 [Article Type] Review
Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System RegulationArticle Published on 2021-04-292024-09-02 Journal: Biomolecules [Category] 대상포진, [키워드] characterization Imuno TF peptides proteomics safety profile transfer factor [DOI] 10.3390/biom11050665 PMC 바로가기 [Article Type] Article
Proteomics and Machine Learning Approaches Reveal a Set of Prognostic Markers for COVID-19 Severity With Drug Repurposing PotentialPhysiology Published on 2021-04-272022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Accuracy Activation Analysis approach assays biological processe Biomarker Blood coagulation Classifier Cohort complement COVID-19 COVID-19 negative COVID-19 patient COVID-19 plasma COVID-19 severity COVID-19 therapeutics differentially expressed drug drug-repurposing dysregulation Exocytosis FDA-approved drugs fibrinogen glucocorticoid groups healthcare Host host response identify immune response in silico Infection involved leukocyte activation linear machine learning management mass spectrometry molecular pathways pandemic of COVID-19 pathogen pathway Patient performed physiological response plasma Potential Potential biomarker Prognosis Prognostic biomarkers Prognostic marker progression Protein proteome proteomics provide Quantitative regulated repurposing reveal SARS-CoV-2 SARS-COV-2 infection selected SERPINA3 SERPING1 Severe case severe COVID-19 severity Support target target protein the disease the patient therapeutic therapeutic interventions [DOI] 10.3389/fphys.2021.652799 PMC 바로가기 [Article Type] Physiology
Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19조절되지 않는 선천 및 적응 면역 반응이 COVID-19의 질병 중증도를 구별합니다Article Published on 2021-04-232022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] abrogated adaptive Adaptive immunity Analysis Biomarkers Cell Clustering analysis COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients Critical Critically ill critically ill patients cytokine cytokine production Cytokines disease disease severity exhaustion markers flow cytometry hepatocyte growth factor highlight highlighting host response Hyperinflammatory immune response immune responses Inflammatory Inflammatory responses Innate innate immune innate immune response innate immune responses Innate immunity interferon interferon-γ interleukin interleukin-17 lymphopenia mononuclear cell performed Peripheral blood Plasma cytokine Potential biomarker potential biomarkers proinflammatory proteomics provide response Result stem cell stem cell factor T-cell exhaustion Variation Whole blood [DOI] 10.1093/infdis/jiab065 PMC 바로가기 [Article Type] Article
Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2Article Published on 2021-04-202022-10-30 Journal: iScience [Category] COVID-19, [키워드] absence Abstract antiviral assay Biology Caco-2 Caco2 Caco2 cells Calu-3 Cell Cell Biology cell line cellular pathways cellular response Characteristics Cytopathic effect dysregulated experimental model growth Huh7 HUH7 cells human cell lines interferon response interferon signaling Laboratory pathogenicity performed Protein proteomics Quantitative Regulation SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible susceptible cell Swedish Variability Variation Virology virus virus production viruses [DOI] 10.1016/j.isci.2021.102420 PMC 바로가기 [Article Type] Article
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV Research Published on 2021-04-122022-10-05 Journal: Nature [Category] SARS, 신약개발, 치료제, [키워드] Antiviral effect autophagy both viruses cellular interaction Coronaviruses COVID-19 dataset drug dysregulated fibrosis heterogeneity highlight Host Host-directed therapies hotspot human cell infection with SARS-CoV-2 inhibitor integration Interaction kinase knowledge matrix metalloprotease molecular function molecular mechanism ORF3 ORF8 pathogenic pathway Perturbation phosphoproteome proteome proteomics reveal SARS-CoV SARS-CoV-2 Spread TGF-β These data tissue to define Transcriptome Viral protein virus virus–host interaction [DOI] 10.1038/s41586-021-03493-4 [Article Type] Research
Application of spectral library prediction for parallel reaction monitoring of viral peptides바이러스 펩타이드의 병렬 반응 모니터링을 위한 스펙트럼 라이브러리 예측 적용Article Published on 2021-04-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, [키워드] acquisition Algorithm Analysis analyzed applicability application can be used Data analysis example identify IMPROVE in silico intensity oropharyngeal swab parallel reaction monitoring peptide peptides precursor predict predicted PRM proteomics SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides significantly tandem mass spectra prediction viral peptide viral peptides Virology virus virus proteomics. [DOI] 10.1002/pmic.202000226 PMC 바로가기 [Article Type] Article
Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment정량적 단백질체학은 COVID-19 치료에 도움이 되는 이버멕틴의 광범위한 항바이러스 특성을 나타냅니다Article Published on 2021-04-012022-09-11 Journal: Journal of cellular physiology [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration Amino acid amino acids Analysis Antibacterial anticancer Antiviral biological processes Cancer cells Cell Cell culture cells cellular components complex coronavirus COVID-19 COVID-19 treatment cytokine Cytokines cytomegalovirus Diseases EBV Epstein-Barr virus G-protein Gene ontology Gene ontology analysis global public health growth factor HCMV Health HIV HIV1 HLA HPV Human Cytomegalovirus Human immunodeficiency virus human papillomavirus identify immunodeficiency virus IMPROVE in vitro Infection inhibit Interaction Ivermectin labeling molecular functions network analysis offer ovarian cancer papillomavirus pathway Pathways Personalized medicine PPI PPI network Predictive Protein Proteins proteomics Quantitative quantitative proteomics regulated Replication replication of SARS-CoV-2 reported reveal SARS-CoV-2/COVID-19 STABLE stable isotope labeling by amino acids in cell culture statistically significant treated Treatment virus virus infection virus-related pathways. was used [DOI] 10.1002/jcp.30055 PMC 바로가기 [Article Type] Article
Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases면역 치료 엑소좀의 단백질 특성, 생체 분포 및 기능 연구: 염증성 폐 질환에 대한 시사점Immunology Published on 2021-03-252022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed binding biodistribution blocking bone disease Cell characterization circulation clinical trial clinical trials complex controls coronavirus COVID-19 DCs dendritic cell dendritic cells disease downregulate downstream Effect Efficacy Exosome Exosomes experiment expression followed by functions identify immature immune immune response immune therapy immunoblot Immunotherapy implication In-vitro Inflammatory Inflammatory diseases inflammatory disorders initial Interaction internalization Intravenous injection involved liver tissue lung Lung diseases Lungs major organ major organs mice parenchymal parenchymal cells peripheral tissues predominant presenting Protein Proteins proteomics respiratory scrutiny Signaling spleen suggested sustained target target proteins target receptor therapeutic therapy transmigration various inflammatory diseases [DOI] 10.3389/fimmu.2021.636222 PMC 바로가기 [Article Type] Immunology
Ultra-fast proteomics with Scanning SWATH Research Published on 2021-03-252022-10-05 Journal: Nature biotechnology [Category] 바이오마커, 치료제, [키워드] accelerate acquisition Biomarker Clinical studies Combination COVID-19 severity experiment experiments facilitate identify increase Isolation large sample Patient plasma plasma proteomics precursor proteome proteomic proteomics quantification Quantitative scanning Tandem mass spectrometry yielding [DOI] 10.1038/s41587-021-00860-4 [Article Type] Research